| 词条 | Small nucleolar RNA Me28S-Am2589 |
| 释义 |
| Name = Small nucleolar RNA Me28S-Am2589 | image = RF00529.jpg | width = | caption = Predicted secondary structure and sequence conservation of snoMe28S-Am2589 | Symbol = snoMe28S-Am2589 | AltSymbols = snoMe28S-Am2589a | Rfam = RF00529 | miRBase = | miRBase_family = | RNA_type = Gene; snRNA; snoRNA; CD-box | Tax_domain = Eukaryota | GO = {{GO|0006396}} {{GO|0005730}} | SO = {{SO|0000593}} | CAS_number = | EntrezGene = | HGNCid = | OMIM = | PDB = | RefSeq = | Chromosome = | Arm = | Band = | LocusSupplementaryData = }} Small nucleolar RNA Me28S-Am2589 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA Me28S-Am2589 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1] It is predicted that this family directs 2'-O-methylation of 28S A-2589.[2] References1. ^{{Cite journal | last1 = Galardi | first1 = S.| last2 = Fatica | first2 = A.| last3 = Bachi | first3 = A.| last4 = Scaloni | first4 = A.| last5 = Presutti | first5 = C.| last6 = Bozzoni | first6 = I.| doi = 10.1128/MCB.22.19.6663-6668.2002 | title = Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro | journal = Molecular and Cellular Biology| volume = 22 | issue = 19 | pages = 6663–6668 | date=October 2002 | pmid = 12215523| pmc = 134041}} 2. ^{{cite journal | last = Huang | first = ZP |author2=Zhou H |author3=He HL |author4=Chen CL |author5=Liang D |author6=Qu LH | year = 2005 | title = Genome-wide analyses of two families of snoRNA genes from Drosophila melanogaster, demonstrating the extensive utilization of introns for coding of snoRNAs | journal = RNA | volume = 11 | pages = 1303–1316 | pmid = 15987805 | doi = 10.1261/rna.2380905 | issue = 8 | pmc = 1370813}} External links
1 : Small nuclear RNA |
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