| 词条 | Small nucleolar RNA SNORA76 |
| 释义 |
| Name = Small nucleolar RNA SNORA76 | image = RF00598.jpg | width = | caption = Predicted secondary structure and sequence conservation of SNORA76 | Symbol = SNORA76 | AltSymbols = | Rfam = RF00598 | miRBase = | miRBase_family = | RNA_type = Gene; snRNA; snoRNA; HACA-box | Tax_domain = Eukaryota | GO = {{GO|0006396}} {{GO|0005730}} | SO = {{SO|0000594}} | CAS_number = | EntrezGene = | HGNCid = | OMIM = | PDB = | RefSeq = | Chromosome = | Arm = | Band = | LocusSupplementaryData = }} In molecular biology, SNORA76 (also known as ACA62) is a non-coding RNA (ncRNA) which modifies other small nuclear RNAs (snRNAs). It is a member of the H/ACA class of small nucleolar RNA that guide the sites of modification of uridines to pseudouridines.[1] This snoRNA was identified by computational screening and its expression in mouse experimentally verified by Northern blot and primer extension analysis.[2] ACA62 is proposed to guide the pseudouridylation of 18S rRNA U34 and U105.[2][3] References1. ^{{Cite journal | last1 = Kiss | first1 = Arnold M. | last2 = Jády | first2 = Beáta E. | last3 = Bertrand | first3 = Edouard | last4 = Kiss | first4 = Tamás | title = Human Box H/ACA Pseudouridylation Guide RNA Machinery | doi = 10.1128/MCB.24.13.5797-5807.2004 | journal = Molecular and Cellular Biology | volume = 24 | issue = 13 | pages = 5797–5807 | pmc = 480876 | year = 2004 | pmid = 15199136}} 2. ^1 {{cite journal |author= Schattner P, Barberan-Soler S, Lowe TM; |title= A computational screen for mammalian pseudouridylation guide H/ACA RNAs |journal= RNA |volume= 12 |issue= 1|pages= 15–25 |year= 2006 |pmid=16373490 |doi= 10.1261/rna.2210406 |pmc= 1370881}} 3. ^{{Cite journal | last1 = Lestrade | first1 = Laurent | last2 = Weber | first2 = Michel J. | title = snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs | doi = 10.1093/nar/gkj002 | journal = Nucleic Acids Research | volume = 34 | issue = Supplement 1: Database Issue | pages = D158–D162 | year = 2006 | pmc = 1347365 | pmid = 16381836 | citeseerx = 10.1.1.105.7552}} External links
1 : Non-coding_RNA |
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