| 词条 | Small nucleolar RNA SNORD16 |
| 释义 |
| Name = Small nucleolar RNA SNORD16 | image = RF00138.jpg | width = | caption = Predicted secondary structure and sequence conservation of SNORD16 | Symbol = SNORD16 | AltSymbols = U16 | Rfam = RF00138 | miRBase = | miRBase_family = | RNA_type = Gene; snRNA; snoRNA; C/D-box | Tax_domain = Eukaryota | GO = {{GO|0006396}} {{GO|0005730}} | SO = {{SO|0000593}} | CAS_number = | EntrezGene = | HGNCid = | OMIM = | PDB = | RefSeq = | Chromosome = | Arm = | Band = | LocusSupplementaryData = }} snoRNA U16 (also known as SNORD16) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA U16 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1] U16 is predicted to guide the 2'O-ribose methylation of 18S ribosomal RNA (rRNA) residue A484 [2] and is encoded within an intron of the gene for ribosomal proteins L1 in animals.[3] This snoRNA was independently named MBII-98 in mouse.[4] References1. ^{{Cite journal | last1 = Galardi | first1 = S.| last2 = Fatica | first2 = A.| last3 = Bachi | first3 = A.| last4 = Scaloni | first4 = A.| last5 = Presutti | first5 = C.| last6 = Bozzoni | first6 = I.| doi = 10.1128/MCB.22.19.6663-6668.2002 | title = Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro | journal = Molecular and Cellular Biology| volume = 22 | issue = 19 | pages = 6663–6668 | date=October 2002 | pmid = 12215523| pmc = 134041}} 2. ^{{Cite journal | last1 = Kiss-László | first1 = Zsuzsanna| last2 = Henry | first2 = Yves| last3 = Bachellerie | first3 = Jean-Pierre| last4 = Caizergues-Ferrer | first4 = Michèle| last5 = Kiss | first5 = Tamás| title = Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs| doi = 10.1016/S0092-8674(00)81308-2 | journal = Cell| volume = 85 | issue = 7 | pages = 1077–1088 | date=June 1996 | pmid = 8674114| pmc = }} 3. ^{{cite journal | last1 = Fragapane | first1 = P. | last2 = Prislei | first2 = S. | last3 = Michienzi | first3 = A. | last4 = Caffarelli | first4 = E. | last5 = Bozzoni | first5 = I. | title = A novel small nucleolar RNA (U16) is encoded inside a ribosomal protein intron and originates by processing of the pre-mRNA | journal = The EMBO Journal | volume = 12 | issue = 7 | pages = 2921–2928 |date=July 1993 | pmid = 8335006 | doi = | pmc = 413545 }} 4. ^{{Cite journal | last1 = Huttenhofer | first1 = Alexander| last2 = Kiefmann | first2 = Martin| last3 = Meier-Ewert | first3 = Sebastian| last4 = O'Brien | first4 = John| last5 = Lehrach | first5 = Hans| last6 = Bachellerie | first6 = Jean-Pierre | last7 = Brosius | first7 = Jürgen| title = RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse| doi = 10.1093/emboj/20.11.2943 | journal = The EMBO Journal| volume = 20 | issue = 11 | pages = 2943–2953 | date = 1 June 2001| pmid = 11387227| pmc = 125495}} External links
1 : Small nuclear RNA |
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