| 词条 | Small nucleolar RNA SNORD42 |
| 释义 |
| Name = Small nucleolar RNA SNORD42 | image = RF00150.jpg | width = | caption = Predicted secondary structure and sequence conservation of SNORD42 | Symbol = SNORD42 | AltSymbols = U42 | Rfam = RF00150 | miRBase = | miRBase_family = | RNA_type = Gene; snRNA; snoRNA; CD-box | Tax_domain = Eukaryota | GO = {{GO|0006396}} {{GO|0005730}} | SO = {{SO|0000593}} | CAS_number = | EntrezGene = | HGNCid = | OMIM = | PDB = | RefSeq = | Chromosome = | Arm = | Band = | LocusSupplementaryData = }} snoRNA U42 (also known as SNORD42) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA U42 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1][2] In the human genome there are two closely related copies of U42 (called U42A and U42B) both located within the introns of the ribosomal protein L23a (RPL23a) gene. Both snoRNAs are predicted to guide the site specific 2'O-ribose methylation of 18S ribosomal RNA (rRNA) residue U116.[3] The mouse orthologue (MBII-287) has also been identified.[4] References1. ^{{cite journal | vauthors = Galardi S, Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I | title = Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro | journal = Molecular and Cellular Biology | volume = 22 | issue = 19 | pages = 6663–8 | date = October 2002 | pmid = 12215523 | pmc = 134041 | doi = 10.1128/MCB.22.19.6663-6668.2002 }} 2. ^{{cite journal | vauthors = Kiss T | title = Small nucleolar RNAs: an abundant group of noncoding RNAs with diverse cellular functions | journal = Cell | volume = 109 | issue = 2 | pages = 145–8 | date = April 2002 | pmid = 12007400 | pmc = | doi = 10.1016/S0092-8674(02)00718-3 }} 3. ^{{cite journal | vauthors = Lestrade L, Weber MJ | title = snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs | journal = Nucleic Acids Research | volume = 34 | issue = Database issue | pages = D158-62 | date = January 2006 | pmid = 16381836 | pmc = 1347365 | doi = 10.1093/nar/gkj002 | citeseerx = 10.1.1.105.7552 }} 4. ^{{cite journal | vauthors = Hüttenhofer A, Kiefmann M, Meier-Ewert S, O'Brien J, Lehrach H, Bachellerie JP, Brosius J | title = RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse | journal = The EMBO Journal | volume = 20 | issue = 11 | pages = 2943–53 | date = June 2001 | pmid = 11387227 | pmc = 125495 | doi = 10.1093/emboj/20.11.2943 }} External links
1 : Small nuclear RNA |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。