| 词条 | Small nucleolar RNA SNORD53 |
| 释义 |
| Name = Small nucleolar RNA SNORD53/SNORD92 | image = RF00325.jpg | width = | caption = Predicted secondary structure and sequence conservation of SNORD53_SNORD92 | Symbol = SNORD53_SNORD92 | AltSymbols = SNORD53; U53 | Rfam = RF00325 | miRBase = | miRBase_family = | RNA_type = Gene; snRNA; snoRNA; C/D-box | Tax_domain = Eukaryota | GO = {{GO|0006396}} {{GO|0005730}} | SO = {{SO|0000593}} | CAS_number = | EntrezGene = | HGNCid = | OMIM = | PDB = | RefSeq = | Chromosome = | Arm = | Band = | LocusSupplementaryData = }} snoRNA U53 (also known as SNORD53) is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA U53 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1][2] U53 was originally cloned from HeLa cells and is predicted to guide the 2'O-ribose methylation of 28S ribosomal RNA (rRNA) at residue C3848.[3][4] It is related to mouse snoRNA MBII-35[5] References1. ^{{Cite journal | last1 = Galardi | first1 = S.| last2 = Fatica | first2 = A.| last3 = Bachi | first3 = A.| last4 = Scaloni | first4 = A.| last5 = Presutti | first5 = C.| last6 = Bozzoni | first6 = I.| doi = 10.1128/MCB.22.19.6663-6668.2002 | title = Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro | journal = Molecular and Cellular Biology| volume = 22 | issue = 19 | pages = 6663–6668 | date=October 2002 | pmid = 12215523| pmc = 134041}} 2. ^{{Cite journal | last1 = Kiss | first1 = Tamás| title = Small Nucleolar RNAs | doi = 10.1016/S0092-8674(02)00718-3 | journal = Cell | volume = 109 | issue = 2 | pages = 145–148 | year = 2002 | pmid = 12007400| pmc = }} 3. ^{{Cite journal | last1 = Kiss-László | first1 = Zsuzsanna| last2 = Henry | first2 = Yves| last3 = Bachellerie | first3 = Jean-Pierre| last4 = Caizergues-Ferrer | first4 = Michèle| last5 = Kiss | first5 = Tamás| title = Site-specific ribose methylation of preribosomal RNA: a novel function for small nucleolar RNAs| doi = 10.1016/S0092-8674(00)81308-2 | journal = Cell| volume = 85 | issue = 7 | pages = 1077–1088 | date=June 1996 | pmid = 8674114| pmc = }} 4. ^{{Cite journal | last1 = Lestrade | first1 = Laurent | last2 = Weber | first2 = Michel J. | title = snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs | doi = 10.1093/nar/gkj002 | journal = Nucleic Acids Research | volume = 34 | issue = Supplement 1: Database Issue | pages = D158–D162 | year = 2006 | pmc = 1347365 | pmid = 16381836 | citeseerx = 10.1.1.105.7552}} 5. ^{{Cite journal | last1 = Huttenhofer | first1 = Alexander| last2 = Kiefmann | first2 = Martin| last3 = Meier-Ewert | first3 = Sebastian| last4 = O'Brien | first4 = John| last5 = Lehrach | first5 = Hans| last6 = Bachellerie | first6 = Jean-Pierre | last7 = Brosius | first7 = Jürgen| title = RNomics: an experimental approach that identifies 201 candidates for novel, small, non-messenger RNAs in mouse| doi = 10.1093/emboj/20.11.2943 | journal = The EMBO Journal| volume = 20 | issue = 11 | pages = 2943–2953 | date = 1 June 2001| pmid = 11387227| pmc = 125495}} External links
1 : Small nuclear RNA |
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