| 词条 | Small nucleolar RNA snR66 |
| 释义 |
| Name = Small nucleolar RNA snR66 | image = RF00477.jpg | width = | caption = Predicted secondary structure and sequence conservation of snosnR66 | Symbol = snosnR66 | AltSymbols = | Rfam = RF00477 | miRBase = | miRBase_family = | RNA_type = Gene; snRNA; snoRNA; CD-box | Tax_domain = Eukaryota | GO = {{GO|0006396}} {{GO|0005730}} | SO = {{SO|0000593}} | CAS_number = | EntrezGene = | HGNCid = | OMIM = | PDB = | RefSeq = | Chromosome = | Arm = | Band = | LocusSupplementaryData = }} snoRNA snR66 is a non-coding RNA (ncRNA) molecule which functions in the modification of other small nuclear RNAs (snRNAs). This type of modifying RNA is usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis. It is known as a small nucleolar RNA (snoRNA) and also often referred to as a guide RNA. snoRNA snR66 belongs to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs.[1] snoRNA snR66 was initially discovered using a computational screen of the Saccharomyces cerevisiae genome.[2] References1. ^{{Cite journal | last1 = Galardi | first1 = S.| last2 = Fatica | first2 = A.| last3 = Bachi | first3 = A.| last4 = Scaloni | first4 = A.| last5 = Presutti | first5 = C.| last6 = Bozzoni | first6 = I.| doi = 10.1128/MCB.22.19.6663-6668.2002 | title = Purified Box C/D snoRNPs Are Able to Reproduce Site-Specific 2'-O-Methylation of Target RNA in Vitro | journal = Molecular and Cellular Biology| volume = 22 | issue = 19 | pages = 6663–6668 | date=October 2002 | pmid = 12215523| pmc = 134041}} 2. ^{{Cite journal | last1 = Lowe | first1 = T. M. | last2 = Eddy | first2 = S. R. | title = A Computational Screen for Methylation Guide snoRNAs in Yeast | doi = 10.1126/science.283.5405.1168 | journal = Science | volume = 283 | issue = 5405 | pages = 1168–1171 | date=February 1999 | pmid = 10024243| pmc = | bibcode = 1999Sci...283.1168L}} External links
1 : Small nuclear RNA |
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