“S-methyl-5-thioribose-1-phosphate isomerase”的意思、由来-开放百科全书

词条

S-methyl-5-thioribose-1-phosphate isomerase

释义

Structural studies
References

{{enzyme
| Name = S-methyl-5-thioribose-1-phosphate isomerase
| EC_number = 5.3.1.23
| CAS_number = 91608-95-6
| IUBMB_EC_number = 5/3/1/23
| GO_code = 0046523
| image =
| width =
| caption =
}}

In enzymology, a S-methyl-5-thioribose-1-phosphate isomerase ({{EC number|5.3.1.23}}) is an enzyme that catalyzes the chemical reaction

S-methyl-5-thio-alpha-D-ribose 1-phosphate S-methyl-5-thio-D-ribulose 1-phosphate

Hence, this enzyme has one substrate, S-methyl-5-thio-alpha-D-ribose 1-phosphate, and one product, S-methyl-5-thio-D-ribulose 1-phosphate.

This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases interconverting aldoses and ketoses. The systematic name of this enzyme class is S-methyl-5-thio-alpha-D-ribose-1-phosphate aldose-ketose-isomerase. Other names in common use include methylthioribose 1-phosphate isomerase, 1-PMTR isomerase, 5-methylthio-5-deoxy-D-ribose-1-phosphate ketol-isomerase, S-methyl-5-thio-5-deoxy-D-ribose-1-phosphate ketol-isomerase, S-methyl-5-thio-5-deoxy-D-ribose-1-phosphate, aldose-ketose-isomerase, 1-phospho-5'-S-methylthioribose isomerase, and S-methyl-5-thio-D-ribose-1-phosphate aldose-ketose-isomerase. This enzyme participates in methionine metabolism.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1T9K}} and {{PDB link|1W2W}}.

References

{{cite journal | author = RH | date = 1984 | title = Characterization of a defect in the pathway for converting 5'-deoxy-5'-methylthioadenosine to methionine in a subline of a cultured heterogeneous human colon carcinoma | journal = J. Biol. Chem. | volume = 259 | pages = 6715–9 | pmid = 6725268 | last2 = Savarese | first2 = TM | last3 = Dexter | first3 = DL | last4 = Parks Jr | first4 = RE | last5 = Trackman | first5 = PC | last6 = Abeles | first6 = RH | issue = 11 }}
{{cite journal |vauthors = Trackman PC, Abeles RH | date = 1983 | title = Methionine synthesis from 5'-S-Methylthioadenosine. Resolution of enzyme activities identification of 1-phospho-5-S methylthioribulose | journal = J. Biol. Chem. | volume = 258 | pages = 6717–20 | pmid = 6853500 | issue = 11 }}
{{cite journal | vauthors = Furfine ES, Abeles RH | date = 1988 | title = Intermediates in the conversion of 5'-S-methylthioadenosine to methionine in Klebsiella pneumoniae | journal = J. Biol. Chem. | volume = 263 | pages = 9598–606 | pmid = 2838472 | issue = 20 }}

2 : EC 5.3.1|Enzymes of known structure

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