请输入您要查询的百科知识：

　

词条 SNAP23
释义

  1. Function

  2. Clinical significance

  3. Interactions

  4. References

  5. Further reading

{{Infobox_gene}}

Synaptosomal-associated protein 23 is a protein that in humans is encoded by the SNAP23 gene.[1][2] Two alternative transcript variants encoding different protein isoforms have been described for this gene.

Function

Specificity of vesicular transport is regulated, in part, by the interaction of a vesicle-associated membrane protein termed synaptobrevin/VAMP with a target compartment membrane protein termed syntaxin. These proteins, together with SNAP25 (synaptosome-associated protein of 25 kDa), form a complex which serves as a binding site for the general membrane fusion machinery. Synaptobrevin/VAMP and syntaxin are believed to be involved in vesicular transport in most, if not all cells, while SNAP25 is present almost exclusively in the brain, suggesting that a ubiquitously expressed homolog of SNAP25 exists to facilitate transport vesicle/target membrane fusion in other tissues.

SNAP23 is structurally and functionally similar to SNAP25 and binds tightly to multiple syntaxins and synaptobrevins/VAMPs. It is an essential component of the high affinity receptor for the general membrane fusion machinery and is an important regulator of transport vesicle docking and fusion.[3]

Clinical significance

In individuals with insulin resistance, SNAP23 is found to be translocated from the plasma membrane to the cytosol where it becomes associated with lipid droplets and is therefore unable to translocate GLUT-4 to the membrane, hindering glucose transport.

Interactions

SNAP23 has been shown to interact with:

{{div col|colwidth=20em}}
  • Cystic fibrosis transmembrane conductance regulator,[4]
  • KIF5B,[5]
  • NAPA,[6]
  • SNAPAP,[7]
  • STX11,[6][8]
  • STX1A,[2][11][12][13][14]
  • STX2,[2][9][10][11]
  • STX4,[2][9][10][11][23][24][12][13]
  • STX6,[14]
  • SYBL1,[15][16]
  • Syntaxin 3,[2][9][11][12]
  • VAMP2,[9][17][18]
  • VAMP3,[9][17][13] and
  • Vesicle-associated membrane protein 8.[9][17]
{{Div col end}}

References

1. ^{{cite journal | vauthors = Mollinedo F, Lazo PA | title = Identification of two isoforms of the vesicle-membrane fusion protein SNAP-23 in human neutrophils and HL-60 cells | journal = Biochemical and Biophysical Research Communications | volume = 231 | issue = 3 | pages = 808–12 | date = Feb 1997 | pmid = 9070898 | pmc = | doi = 10.1006/bbrc.1997.6196 }}
2. ^1 2 3 4 {{cite journal | vauthors = Ravichandran V, Chawla A, Roche PA | title = Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues | journal = The Journal of Biological Chemistry | volume = 271 | issue = 23 | pages = 13300–3 | date = Jun 1996 | pmid = 8663154 | pmc = | doi = 10.1074/jbc.271.23.13300 }}
3. ^{{cite web | title = Entrez Gene: SNAP23 synaptosomal-associated protein, 23kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8773| accessdate = }}
4. ^{{cite journal | vauthors = Cormet-Boyaka E, Di A, Chang SY, Naren AP, Tousson A, Nelson DJ, Kirk KL | title = CFTR chloride channels are regulated by a SNAP-23/syntaxin 1A complex | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 99 | issue = 19 | pages = 12477–82 | date = Sep 2002 | pmid = 12209004 | pmc = 129470 | doi = 10.1073/pnas.192203899 }}
5. ^{{cite journal | vauthors = Diefenbach RJ, Diefenbach E, Douglas MW, Cunningham AL | title = The heavy chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23 | journal = Biochemistry | volume = 41 | issue = 50 | pages = 14906–15 | date = Dec 2002 | pmid = 12475239 | doi = 10.1021/bi026417u}}
6. ^1 {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
7. ^{{cite journal | vauthors = Buxton P, Zhang XM, Walsh B, Sriratana A, Schenberg I, Manickam E, Rowe T | title = Identification and characterization of Snapin as a ubiquitously expressed SNARE-binding protein that interacts with SNAP23 in non-neuronal cells | journal = The Biochemical Journal | volume = 375 | issue = Pt 2 | pages = 433–40 | date = Oct 2003 | pmid = 12877659 | pmc = 1223698 | doi = 10.1042/BJ20030427 }}
8. ^{{cite journal | vauthors = Valdez AC, Cabaniols JP, Brown MJ, Roche PA | title = Syntaxin 11 is associated with SNAP-23 on late endosomes and the trans-Golgi network | journal = Journal of Cell Science | volume = 112 | issue = 6| pages = 845–54 | date = Mar 1999 | pmid = 10036234 | doi = }}
9. ^1 2 3 4 5 6 {{cite journal | vauthors = Imai A, Nashida T, Yoshie S, Shimomura H | title = Intracellular localisation of SNARE proteins in rat parotid acinar cells: SNARE complexes on the apical plasma membrane | journal = Archives of Oral Biology | volume = 48 | issue = 8 | pages = 597–604 | date = Aug 2003 | pmid = 12828989 | doi = 10.1016/S0003-9969(03)00116-X}}
10. ^1 2 {{cite journal | vauthors = Li G, Alexander EA, Schwartz JH | title = Syntaxin isoform specificity in the regulation of renal H+-ATPase exocytosis | journal = The Journal of Biological Chemistry | volume = 278 | issue = 22 | pages = 19791–7 | date = May 2003 | pmid = 12651853 | doi = 10.1074/jbc.M212250200 }}
11. ^1 2 3 {{cite journal | vauthors = Araki S, Tamori Y, Kawanishi M, Shinoda H, Masugi J, Mori H, Niki T, Okazawa H, Kubota T, Kasuga M | title = Inhibition of the binding of SNAP-23 to syntaxin 4 by Munc18c | journal = Biochemical and Biophysical Research Communications | volume = 234 | issue = 1 | pages = 257–62 | date = May 1997 | pmid = 9168999 | doi = 10.1006/bbrc.1997.6560 }}
12. ^1 2 {{cite journal | vauthors = Steegmaier M, Yang B, Yoo JS, Huang B, Shen M, Yu S, Luo Y, Scheller RH | title = Three novel proteins of the syntaxin/SNAP-25 family | journal = The Journal of Biological Chemistry | volume = 273 | issue = 51 | pages = 34171–9 | date = Dec 1998 | pmid = 9852078 | doi = 10.1074/jbc.273.51.34171}}
13. ^1 {{cite journal | vauthors = Freedman SJ, Song HK, Xu Y, Sun ZY, Eck MJ | title = Homotetrameric structure of the SNAP-23 N-terminal coiled-coil domain | journal = The Journal of Biological Chemistry | volume = 278 | issue = 15 | pages = 13462–7 | date = Apr 2003 | pmid = 12556468 | doi = 10.1074/jbc.M210483200 }}
14. ^{{cite journal | vauthors = Martín-Martín B, Nabokina SM, Blasi J, Lazo PA, Mollinedo F | title = Involvement of SNAP-23 and syntaxin 6 in human neutrophil exocytosis | journal = Blood | volume = 96 | issue = 7 | pages = 2574–83 | date = Oct 2000 | pmid = 11001914 | doi = }}
15. ^{{cite journal | vauthors = Martinez-Arca S, Rudge R, Vacca M, Raposo G, Camonis J, Proux-Gillardeaux V, Daviet L, Formstecher E, Hamburger A, Filippini F, D'Esposito M, Galli T | title = A dual mechanism controlling the localization and function of exocytic v-SNAREs | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 15 | pages = 9011–6 | date = Jul 2003 | pmid = 12853575 | pmc = 166429 | doi = 10.1073/pnas.1431910100 }}
16. ^{{cite journal | vauthors = Galli T, Zahraoui A, Vaidyanathan VV, Raposo G, Tian JM, Karin M, Niemann H, Louvard D | title = A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells | journal = Molecular Biology of the Cell | volume = 9 | issue = 6 | pages = 1437–48 | date = Jun 1998 | pmid = 9614185 | pmc = 25366 | doi = 10.1091/mbc.9.6.1437}}
17. ^1 2 3 {{cite journal | vauthors = Paumet F, Le Mao J, Martin S, Galli T, David B, Blank U, Roa M | title = Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast cells: functional role of syntaxin 4 in exocytosis and identification of a vesicle-associated membrane protein 8-containing secretory compartment | journal = Journal of Immunology | volume = 164 | issue = 11 | pages = 5850–7 | date = Jun 2000 | pmid = 10820264 | doi = 10.4049/jimmunol.164.11.5850}}
18. ^1 {{cite journal | vauthors = Kawanishi M, Tamori Y, Okazawa H, Araki S, Shinoda H, Kasuga M | title = Role of SNAP23 in insulin-induced translocation of GLUT4 in 3T3-L1 adipocytes. Mediation of complex formation between syntaxin4 and VAMP2 | journal = The Journal of Biological Chemistry | volume = 275 | issue = 11 | pages = 8240–7 | date = Mar 2000 | pmid = 10713150 | doi = 10.1074/jbc.275.11.8240}}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Araki S, Tamori Y, Kawanishi M, Shinoda H, Masugi J, Mori H, Niki T, Okazawa H, Kubota T, Kasuga M | title = Inhibition of the binding of SNAP-23 to syntaxin 4 by Munc18c | journal = Biochemical and Biophysical Research Communications | volume = 234 | issue = 1 | pages = 257–62 | date = May 1997 | pmid = 9168999 | doi = 10.1006/bbrc.1997.6560 }}
  • {{cite journal | vauthors = Tang BL, Tan AE, Lim LK, Lee SS, Low DY, Hong W | title = Syntaxin 12, a member of the syntaxin family localized to the endosome | journal = The Journal of Biological Chemistry | volume = 273 | issue = 12 | pages = 6944–50 | date = Mar 1998 | pmid = 9507000 | doi = 10.1074/jbc.273.12.6944 }}
  • {{cite journal | vauthors = Galli T, Zahraoui A, Vaidyanathan VV, Raposo G, Tian JM, Karin M, Niemann H, Louvard D | title = A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells | journal = Molecular Biology of the Cell | volume = 9 | issue = 6 | pages = 1437–48 | date = Jun 1998 | pmid = 9614185 | pmc = 25366 | doi = 10.1091/mbc.9.6.1437 }}
  • {{cite journal | vauthors = Foster LJ, Yeung B, Mohtashami M, Ross K, Trimble WS, Klip A | title = Binary interactions of the SNARE proteins syntaxin-4, SNAP23, and VAMP-2 and their regulation by phosphorylation | journal = Biochemistry | volume = 37 | issue = 31 | pages = 11089–96 | date = Aug 1998 | pmid = 9693005 | doi = 10.1021/bi980253t }}
  • {{cite journal | vauthors = Riento K, Galli T, Jansson S, Ehnholm C, Lehtonen E, Olkkonen VM | title = Interaction of Munc-18-2 with syntaxin 3 controls the association of apical SNAREs in epithelial cells | journal = Journal of Cell Science | volume = 111 | issue = 17 | pages = 2681–8 | date = Sep 1998 | pmid = 9701566 | doi = }}
  • {{cite journal | vauthors = Guo Z, Turner C, Castle D | title = Relocation of the t-SNARE SNAP-23 from lamellipodia-like cell surface projections regulates compound exocytosis in mast cells | journal = Cell | volume = 94 | issue = 4 | pages = 537–48 | date = Aug 1998 | pmid = 9727496 | doi = 10.1016/S0092-8674(00)81594-9 }}
  • {{cite journal | vauthors = Inoue T, Nielsen S, Mandon B, Terris J, Kishore BK, Knepper MA | title = SNAP-23 in rat kidney: colocalization with aquaporin-2 in collecting duct vesicles | journal = The American Journal of Physiology | volume = 275 | issue = 5 Pt 2 | pages = F752–60 | date = Nov 1998 | pmid = 9815132 | doi = }}
  • {{cite journal | vauthors = Valdez AC, Cabaniols JP, Brown MJ, Roche PA | title = Syntaxin 11 is associated with SNAP-23 on late endosomes and the trans-Golgi network | journal = Journal of Cell Science | volume = 112 | issue = 6 | pages = 845–54 | date = Mar 1999 | pmid = 10036234 | doi = }}
  • {{cite journal | vauthors = Okamoto M, Schoch S, Südhof TC | title = EHSH1/intersectin, a protein that contains EH and SH3 domains and binds to dynamin and SNAP-25. A protein connection between exocytosis and endocytosis? | journal = The Journal of Biological Chemistry | volume = 274 | issue = 26 | pages = 18446–54 | date = Jun 1999 | pmid = 10373452 | doi = 10.1074/jbc.274.26.18446 }}
  • {{cite journal | vauthors = Cabaniols JP, Ravichandran V, Roche PA | title = Phosphorylation of SNAP-23 by the novel kinase SNAK regulates t-SNARE complex assembly | journal = Molecular Biology of the Cell | volume = 10 | issue = 12 | pages = 4033–41 | date = Dec 1999 | pmid = 10588641 | pmc = 25741 | doi = 10.1091/mbc.10.12.4033 }}
  • {{cite journal | vauthors = Kawanishi M, Tamori Y, Okazawa H, Araki S, Shinoda H, Kasuga M | title = Role of SNAP23 in insulin-induced translocation of GLUT4 in 3T3-L1 adipocytes. Mediation of complex formation between syntaxin4 and VAMP2 | journal = The Journal of Biological Chemistry | volume = 275 | issue = 11 | pages = 8240–7 | date = Mar 2000 | pmid = 10713150 | doi = 10.1074/jbc.275.11.8240 }}
  • {{cite journal | vauthors = Paumet F, Le Mao J, Martin S, Galli T, David B, Blank U, Roa M | title = Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast cells: functional role of syntaxin 4 in exocytosis and identification of a vesicle-associated membrane protein 8-containing secretory compartment | journal = Journal of Immunology | volume = 164 | issue = 11 | pages = 5850–7 | date = Jun 2000 | pmid = 10820264 | doi = 10.4049/jimmunol.164.11.5850 }}
  • {{cite journal | vauthors = Scales SJ, Chen YA, Yoo BY, Patel SM, Doung YC, Scheller RH | title = SNAREs contribute to the specificity of membrane fusion | journal = Neuron | volume = 26 | issue = 2 | pages = 457–64 | date = May 2000 | pmid = 10839363 | doi = 10.1016/S0896-6273(00)81177-0 }}
  • {{cite journal | vauthors = Martín-Martín B, Nabokina SM, Blasi J, Lazo PA, Mollinedo F | title = Involvement of SNAP-23 and syntaxin 6 in human neutrophil exocytosis | journal = Blood | volume = 96 | issue = 7 | pages = 2574–83 | date = Oct 2000 | pmid = 11001914 | doi = }}
  • {{cite journal | vauthors = Faigle W, Colucci-Guyon E, Louvard D, Amigorena S, Galli T | title = Vimentin filaments in fibroblasts are a reservoir for SNAP23, a component of the membrane fusion machinery | journal = Molecular Biology of the Cell | volume = 11 | issue = 10 | pages = 3485–94 | date = Oct 2000 | pmid = 11029050 | pmc = 15008 | doi = 10.1091/mbc.11.10.3485 }}
  • {{cite journal | vauthors = Lazo PA, Nadal M, Ferrer M, Area E, Hernández-Torres J, Nabokina SM, Mollinedo F, Estivill X | title = Genomic organization, chromosomal localization, alternative splicing, and isoforms of the human synaptosome-associated protein-23 gene implicated in vesicle-membrane fusion processes | journal = Human Genetics | volume = 108 | issue = 3 | pages = 211–5 | date = Mar 2001 | pmid = 11354632 | doi = 10.1007/s004390100480 }}
  • {{cite journal | vauthors = Shukla A, Corydon TJ, Nielsen S, Hoffmann HJ, Dahl R | title = Identification of three new splice variants of the SNARE protein SNAP-23 | journal = Biochemical and Biophysical Research Communications | volume = 285 | issue = 2 | pages = 320–7 | date = Jul 2001 | pmid = 11444845 | doi = 10.1006/bbrc.2001.5144 }}
  • {{cite journal | vauthors = Logan MR, Lacy P, Bablitz B, Moqbel R | title = Expression of eosinophil target SNAREs as potential cognate receptors for vesicle-associated membrane protein-2 in exocytosis | journal = The Journal of Allergy and Clinical Immunology | volume = 109 | issue = 2 | pages = 299–306 | date = Feb 2002 | pmid = 11842301 | doi = 10.1067/mai.2002.121453 }}
{{refend}}{{PDB Gallery|geneid=8773}}
随便看

　

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。

　

Copyright © 2023 OENC.NET All Rights Reserved
京ICP备2021023879号 更新时间：2024/9/20 8:47:53