| 词条 | Sodium ascorbate |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 414219642 | Reference = [1] | Name = Sodium L-ascorbate | ImageFile = sodium ascorbate.png | ImageSize = 200px | ImageFile2 = Sodium ascorbate powder.jpg | IUPACName = Sodium (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2H-furan-3-olate | OtherNames = Sodascorbate; Monosodium ascorbate; E301 |Section1={{Chembox Identifiers | UNII_Ref = {{fdacite|changed|FDA}} | UNII = S033EH8359 | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D05853 | CASNo_Ref = {{cascite|correct|CAS}} | CASNo = 134-03-2 | PubChem = 23667548 | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 591665 | ChEBI_Ref = {{ebicite|changed|EBI}} | ChEBI = 113451 | InChI = 1S/C6H8O6.Na/c7-1-2(8)5-3(9)4(10)6(11)12-5;/h2,5,7-10H, 1H2;/q;+1/p-1/t2-,5+;/m0./s1 | SMILES = OC1=C([O-])[C@]([C@@H](O)CO)([H])OC1=O.[Na+] | EINECS = 205-126-1 | RTECS = CI7671000 }} |Section2={{Chembox Properties | C=6 | H=7 | Na=1 | O=6 | Appearance = minute white to yellow crystals | Odor = odorless | Density = 1.66 g/cm3 | MeltingPtC = 218 | MeltingPt_notes = (decomposes) | BoilingPt = | Solubility = 62 g/100 mL (25 °C) 78 g/100 mL (75 °C) | SolubleOther = very slightly soluble in alcohol insoluble in chloroform, ether }} |Section3={{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = | NFPA-H = 0 | NFPA-F = 0 | NFPA-R = 0 }}Sodium ascorbate is one of a number of mineral salts of ascorbic acid (vitamin C). The molecular formula of this chemical compound is C6H7NaO6. As the sodium salt of ascorbic acid, it is known as a mineral ascorbate. It has not been demonstrated to be more bioavailable than any other form of vitamin C supplement.[2] Sodium ascorbate normally provides 131 mg of sodium per 1,000 mg of ascorbic acid (1,000 mg of sodium ascorbate contains 889 mg of ascorbic acid and 111 mg of sodium). As a food additive, it has the E number E301 and is used as an antioxidant and an acidity regulator. It is approved for use as a food additive in the EU,[3] USA,[4] and Australia and New Zealand.[5] In in vitro studies, sodium ascorbate has been found to produce cytotoxic effects in various malignant cell lines, which include melanoma cells that are particularly susceptible.[6][7] ProductionSodium ascorbate is produced by dissolving ascorbic acid in water and adding an equivalent amount of sodium bicarbonate in water. After cessation of effervescence, the sodium ascorbate is precipitated by the addition of isopropanol. References1. ^(+)-Sodium L-ascorbate at Sigma-Aldrich 2. ^Linus Pauling Institute, Oregon Stare University: {{cite web |url=http://lpi.oregonstate.edu/ss01/bioavailability.html |title= Bioavailability of Different Forms of Vitamin C |accessdate=2013-09-27}} 3. ^UK Food Standards Agency: {{cite web |url=http://www.food.gov.uk/safereating/chemsafe/additivesbranch/enumberlist |title=Current EU approved additives and their E Numbers |accessdate=2011-10-27}} 4. ^US Food and Drug Administration: {{cite web |url=http://www.fda.gov/Food/FoodIngredientsPackaging/FoodAdditives/ucm191033.htm#ftnT |title=Listing of Food Additives Status Part II |accessdate=2011-10-27}} 5. ^Australia New Zealand Food Standards Code{{cite web |url=http://www.comlaw.gov.au/Details/F2011C00827 |title=Standard 1.2.4 - Labelling of ingredients |accessdate=2011-10-27}} 6. ^{{cite journal| doi=10.1073/pnas.0506390102|vauthors=Chen Q, Espey MG, Krishna MC, Mitchell JB, Corpe CP, Buettner GR, Shacter E, Levine M |title=Pharmacologic ascorbic acid concentrations selectively kill cancer cells: Action as a pro-drug to deliver hydrogen peroxide to tissues|journal=Proc Natl Acad Sci U S A| volume=102 | issue=38| pages=13604–9| date=September 2005| pmid=16157892 | url=| pmc=1224653}} 7. ^{{cite journal| doi=10.1002/jcp.20286|vauthors=Kang JS, Cho D, Kim YI, Hahm E, Kim YS, Jin SN, Kim HN, Kim D, Hur D, Park H, Hwang YI, Lee WJ |title=Sodium ascorbate (vitamin C) induces apoptosis in melanoma cells via the down-regulation of transferrin receptor dependent iron uptake|journal=J. Cell. Physiol.| volume=204 | issue=1| pages=192–7| date=July 2005| pmid=15672419 | url=}} External links
6 : Ascorbates|Food additives|Organic sodium salts|Vitamers|Vitamin C|E-number additives |
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