| 词条 | Sodium aurothiosulfate |
| 释义 |
| verifiedrevid = 447986969 | IUPAC_name = trisodium dithiosulphate aurate(I), dihydrate | image = Na3Au(S2O3)2.png | image2 = Sodium-gold(I)-thiosulfate-dihydrate-unit-cell-3D-balls.png | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = Intramuscular injection | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 18497-75-1 | ATC_prefix = M01 | ATC_suffix = CB02 | PubChem = 170028 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | chemical_formula = | Au=1 | Na=3 | O=6 | S=4 | molecular_weight = 332.08452 g/mol }}Sodium aurothiosulfate is the inorganic compound with the formula Na3Au(S2O3)2·2H2O. This salt contains an anionic linear coordination complex of gold(I) bound to two thiosulfate ligands.[1][2] Like several other gold compounds, this species is used as an antirheumatic.[3] The first placebo-controlled trial was probably conducted in 1931, when sanocrysin was compared with distilled water for the treatment of tuberculosis.[4] References1. ^{{cite journal | doi = 10.1016/0022-1902(73)80019-3 | title = Crystal and molecular structure of trisodium dithiosulphate aurate(I), dihydrate, Na3[Au(S2O3)2],2H2O | year = 1973 | author1 = Baggio, R. F. | author2 = Baggio, S. | journal = Journal of Inorganic and Nuclear Chemistry | volume = 35 | pages = 3191–3200 | issue = 9 }} {{Antirheumatic products}}{{Gold compounds}}{{sodium compounds}}2. ^{{cite journal | doi = 10.1016/S1386-1425(97)83024-7 | title = Vibrational spectrum of Sanocrysin | year = 1997 | author1 = Tobön-Zapata, G. | author2 = Etcheverry, S. B. | author3 = Baran, E. J. | journal = Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy | volume = 53 | pages = 183–188 | issue = 2 }} 3. ^{{cite journal | last1=Shaw, III | first1=C. F. | title=Gold-Based Therapeutic Agents| journal=Chemical Reviews | year=1999 | volume=99 | pages=2589–600 | doi=10.1021/cr980431o | pmid=11749494 | issue=9}} 4. ^{{cite book | title = Ethical and regulatory aspects of clinical research: readings and commentary | editor1 = Emanuel, E. J. | editor2 = Crouch, R. A. | editor3 = Arras, J. D. | editor4 = Moreno, J. D. | editor5 = Grady, C. | publisher = Johns Hopkins University Press | year = 2003 | page = 140 | isbn = 978-0801878138 }} Source of Chemical Formula: http://medical.merriam-webster.com/medical/gold%20sodium%20thiomalate {{musculoskeletal-drug-stub}} 6 : Thiosulfates|Gold(Ⅰ) compounds|Sodium compounds|Antirheumatic products|Metal-containing drugs|Gold-sulfur compounds |
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