| 词条 | Sodium picosulfate |
| 释义 |
| Verifiedfields = changed | verifiedrevid = 477002878 | IUPAC_name = disodium (pyridin-2-ylmethylene)di-4,1-phenylene disulfate | image = Sodium picosulfate.svg | width = 260 | image2 = Sodium picosulfate ions ball.png | alt2 = Ball-and-stick model of the component ions of sodium picosulfate | width2 = 240 | tradename = | Drugs.com = {{drugs.com|international|sodium-picosulfate}} | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = Oral | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 10040-45-6 | ATC_prefix = A06 | ATC_suffix = AB08 | ATC_supplemental = {{ATC|A06|AB58}} (combinations) | PubChem = 68654 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 61910 | UNII_Ref = {{fdacite|changed|FDA}} | UNII = LR57574HN8 | C=18 | H=13 | N=1 | Na=2 | O=8 | S=2 | molecular_weight = 481.409 g/mol | smiles = [Na+].[Na+].[O-]S(=O)(=O)Oc1ccc(cc1)C(c2ccc(OS([O-])(=O)=O)cc2)c3ncccc3 | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C18H15NO8S2.2Na/c20-28(21,22)26-15-8-4-13(5-9-15)18(17-3-1-2-12-19-17)14-6-10-16(11-7-14)27-29(23,24)25;;/h1-12,18H,(H,20,21,22)(H,23,24,25);;/q;2*+1/p-2 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = GOZDTZWAMGHLDY-UHFFFAOYSA-L }} Sodium picosulfate (INN, also known as sodium picosulphate) is a contact stimulant laxative used as a treatment for constipation or to prepare the large bowel before colonoscopy or surgery. It is sold under the trade names Sodipic Picofast, Laxoberal, Laxoberon,[1] Purg-Odan, Picolax, Guttalax, Namilax, Pico-Salax,[2] PicoPrep,[3] and Prepopik,[4] among others. EffectsOrally administered sodium picosulfate is generally used for thorough evacuation of the bowel, usually for patients who are preparing to undergo a colonoscopy. It takes 12–24 hours to work, since it works in the colon.[4] Abdominal cramps and diarrhea are normal effects of picosulfate and should be expected. The use of sodium picosulfate has also been associated with certain electrolyte disturbances, such as hyponatremia and hypokalemia.[5] Patients are often required to drink large amounts of clear fluids, to compensate for dehydration and to reestablish normal electrolyte balance. Mechanism of actionSodium picosulfate is a prodrug.[6] It has no significant direct physiological effect on the intestine; however, it is metabolised by gut bacteria into the active compound 4,4'-dihydroxydiphenyl-(2-pyridiyl)methane (DPM, BPHM).[6][7] This compound is a stimulant laxative and increases peristalsis in the gut.[6][8] Sodium picosulfate is typically prescribed in a combined formulation with magnesium citrate, an osmotic laxative. This combination is a highly effective laxative, often prescribed to patients for bowel cleansing prior to colonoscopies.[6][9] References1. ^Website of Merck Pakistan {{Laxatives}}2. ^PICO SALAX Product Information {{webarchive|url=https://web.archive.org/web/20120322215255/http://www.pico-salax.ca/product-information.html |date=2012-03-22 }} 3. ^{{cite journal|journal = Diseases of the Colon & Rectum|year = 2006|volume = 49|issue = 5|pages = 616–620|title = Oral sodium phosphate (Fleet(R)) is a superior colonoscopy preparation to Picoprep(R) (sodium picosulfate-based preparation)|last1 = Tjandra|first1 = Joe J.|last2 = Chan|first2 = Miranda|last3 = Tagkalidis|first3 = Peter P.|pmid = 16525746|doi = 10.1007/s10350-005-0323-2}} 4. ^1 {{cite web|publisher = Food and Drug Administration|url = http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm312315.htm|title = FDA News Release – FDA approves new colon-cleansing drug for colonoscopy prep|date = July 17, 2012|accessdate = December 1, 2016}} 5. ^{{cite journal |date=February 2002 | title = Electrolyte disturbances with sodium picosulfate bowel cleansing products | author = ADRAC | journal = Aust Adv Drug React Bull | volume = 21 | issue = 1}} Free full text from the Australian Therapeutic Goods Administration 6. ^1 2 3 {{Cite journal|title = Mechanism of action and toxicities of purgatives used for colonoscopy preparation|journal = Expert Opinion on Drug Metabolism & Toxicology|date = 2011-01-01|issn = 1742-5255|pmc = 3030244|pmid = 21162694|pages = 89–101|volume = 7|issue = 1|doi = 10.1517/17425255.2011.542411|first = Margaret|last = Adamcewicz|first2 = Dilip|last2 = Bearelly|first3 = Gail|last3 = Porat|first4 = Frank K.|last4 = Friedenberg}} 7. ^{{Cite journal|title = The hydragogue and laxative effect of the sulfuric acid ester and the free diphenol of 4,4′-dihydroxydiphenyl-(pyridyl-2)-methane|journal = Naunyn-Schmiedeberg's Archives of Pharmacology|date = 1972-03-01|issn = 0028-1298|pages = 46–53|volume = 274|issue = 1|doi = 10.1007/BF00501005|first = W.|last = Forth|first2 = G.|last2 = Nell|first3 = W.|last3 = Rummel|first4 = H.|last4 = Andres}} 8. ^{{cite journal|last1=Jauch|first1=R|last2=Hankwitz|first2=R|last3=Beschke|first3=K|last4=Pelzer|first4=H|title=Bis-(p-hydroxyphenyl)-pyridyl-2-methane: The common laxative principle of Bisacodyl and sodium picosulfate.|journal=Arzneimittel-Forschung|date=November 1975|volume=25|issue=11|pages=1796–1800|pmid=1243088}} 9. ^{{Cite journal|title = Comparison of two bowel preparations for colonoscopy: sodium picosulphate with magnesium citrate versus sulphate-free polyethylene glycol lavage solution|journal = The American Journal of Gastroenterology|pages = 1478–1482|volume = 93|issue = 9|doi = 10.1111/j.1572-0241.1998.00467.x|pmid = 9732929|first = Arie|last = Regev|first2 = Gerald|last2 = Fraser|first3 = George|last3 = Delpre|first4 = Alfredo|last4 = Leiser|first5 = Ami|last5 = Neeman|first6 = Eran|last6 = Maoz|first7 = Victor|last7 = Anikin|first8 = Yaron|last8 = Niv|year = 1998}} 4 : Pyridines|Laxatives|Organosulfates|Organic sodium salts |
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