| 词条 | Sodium trichloroacetate |
| 释义 |
|ImageFile=File:Natriumtrichlooracetaat.png |IUPACName=Sodium trichloroacetate |ImageSize=180px |ImageName=Sodium trichloroacetate |Section1={{Chembox Identifiers | CASNo = 650-51-1 | PubChem = 23681045 | ChemSpiderID = 12073 | EC_number = 211-479-2 | RTECS = AJ9100000 | UNII = 2N76A3BRJ0 | InChI=1S/C2HCl3O2.Na/c3-2(4,5)1(6)7;/h(H,6,7);/q;+1/p-1 | StdInChIKey = SAQSTQBVENFSKT-UHFFFAOYSA-M | SMILES = C(C(=O)[O-])(Cl)(Cl)Cl.[Na+] }} |Section2={{Chembox Properties | C=2 | Cl=3 | O=2 | Na=1 | Appearance = White powder | Density = ~1.5 g/mL-1 | LogP = | MolarMass = 185.36 g/mol | MeltingPtC = 200 | BoilingPt = Decomposes | pKa = 0.7 (conjugate acid) | Solubility = 55 g / 100 ml | SolubleOther = Soluble in methanol and ethanol, slightly soluble in acetone, not soluble in ethers and hydrocarbons | VaporPressure = }} |Section7={{Chembox Hazards | MainHazards = Corrosive | GHSPictograms = {{GHS07}}{{GHS09}} | GHSSignalWord = Warning | HPhrases = {{H-phrases|335|400|410}} | PPhrases = {{P-phrases|261|271|273|304+340|312|391|403+233|405|501}} | AutoignitionPt = Non-flammable | FlashPt = Non-flammable | NFPA-H = 3 | NFPA-F = 1 | NFPA-R = 1 | NFPA-S = | LD50 = }} |Section9={{Chembox Related | OtherAnions = Sodium trifluoroacetate | OtherCations = Trichloroacetic acid | OtherCompounds = Sodium chloroacetate Sodium acetate }}}} Sodium trichloroacetate is a chemical compound with a formula of CCl3CO2Na. It is used to increase sensitivity and precision during transcript mapping.[1]PreparationSodium trichloroacetate is made by reaction trichloroacetic acid with sodium hydroxide:
ReactionsBasicityCompared to sodium acetate, The basicity of sodium trichloroacetate is weaker because of the electron-withdrawing nature of the trichloromethyl group. Sodium trifluoroacetate is an even weaker base than that due to higher electronegativity of fluorine atoms. In the presence of strong acids the anion can be protonated:
See also
References1. ^{{Cite journal|last=Murray|first=M. G.|title=Use of sodium trichloroacetate and mung bean nuclease to increase sensitivity and precision during transcript mapping|url=https://www.ncbi.nlm.nih.gov/pubmed/2432801|journal=Analytical Biochemistry|volume=158|issue=1|pages=165–170|issn=0003-2697|pmid=2432801|via=}} 2 : Organic sodium salts|Organochlorides |
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