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词条 Sodium–hydrogen antiporter 1
释义

  1. Function

  2. Interactions

  3. References

  4. Further reading

{{Infobox_gene}}

The sodium-hydrogen antiporter 1 (NHE-1) also known as sodium/hydrogen exchanger 1 or SLC9A1 (SoLute Carrier family 9A1) is an isoform of sodium–hydrogen antiporter that in humans is encoded by the SLC9A1 gene.[1]

Function

The Na+/H+ antiporter (SLC9A1) is a ubiquitous membrane-bound enzyme involved in volume- and pH-regulation of vertebrate cells. It is inhibited by the non-specific diuretic drug amiloride and activated by a variety of signals including growth factors, mitogens, neurotransmitters, tumor promoters, and others.[2]

Interactions

Sodium–hydrogen antiporter 1 has been shown to interact with carbonic anhydrase II[3] and CHP.[4][5][6] It is also the target of the experimental drug rimeporide, which is being developed for the treatment of Duchenne muscular dystrophy.[7]

References

1. ^{{cite journal | vauthors = Fliegel L, Dyck JR, Wang H, Fong C, Haworth RS | title = Cloning and analysis of the human myocardial Na+/H+ exchanger | journal = Mol. Cell. Biochem. | volume = 125 | issue = 2 | pages = 137–43 | date = August 1993 | pmid = 8283968 | doi = 10.1007/BF00936442 }}
2. ^{{cite journal | vauthors = Mattei MG, Sardet C, Franchi A, Pouysségur J | title = The human amiloride-sensitive Na+/H+ antiporter: localization to chromosome 1 by in situ hybridization | journal = Cytogenet. Cell Genet. | volume = 48 | issue = 1 | pages = 6–8 | year = 1988 | pmid = 2846238 | doi = 10.1159/000132575 }}
3. ^{{cite journal | vauthors = Li X, Alvarez B, Casey JR, Reithmeier RA, Fliegel L | title = Carbonic anhydrase II binds to and enhances activity of the Na+/H+ exchanger | journal = J. Biol. Chem. | volume = 277 | issue = 39 | pages = 36085–91 | date = September 2002 | pmid = 12138085 | doi = 10.1074/jbc.M111952200 }}
4. ^{{cite journal | vauthors = Inoue H, Nakamura Y, Nagita M, Takai T, Masuda M, Nakamura N, Kanazawa H | title = Calcineurin homologous protein isoform 2 (CHP2), Na+/H+ exchangers-binding protein, is expressed in intestinal epithelium | journal = Biol. Pharm. Bull. | volume = 26 | issue = 2 | pages = 148–55 | date = February 2003 | pmid = 12576672 | doi = 10.1248/bpb.26.148 }}
5. ^{{cite journal | vauthors = Lin X, Barber DL | title = A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 22 | pages = 12631–6 | date = October 1996 | pmid = 8901634 | pmc = 38044 | doi = 10.1073/pnas.93.22.12631 }}
6. ^{{cite journal | vauthors = Pang T, Su X, Wakabayashi S, Shigekawa M | title = Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers | journal = J. Biol. Chem. | volume = 276 | issue = 20 | pages = 17367–72 | date = May 2001 | pmid = 11350981 | doi = 10.1074/jbc.M100296200 }}
7. ^{{Cite journal|journal=Österreichische Apothekerzeitung|volume=69|issue=11|page=12|title=Rimeporide|first1=Helmut|last1=Spreitzer|date=26 May 2015|language=German}}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Yu L, Quinn DA, Garg HG, Hales CA | title = Deficiency of the NHE1 gene prevents hypoxia-induced pulmonary hypertension and vascular remodeling | journal = Am. J. Respir. Crit. Care Med. | volume = 177 | issue = 11 | pages = 1276–84 | date = June 2008 | pmid = 18310478 | pmc = 2408441 | doi = 10.1164/rccm.200710-1522OC }}
  • {{cite journal | vauthors = Rios EJ, Fallon M, Wang J, Shimoda LA | title = Chronic hypoxia elevates intracellular pH and activates Na+/H+ exchange in pulmonary arterial smooth muscle cells | journal = Am. J. Physiol. Lung Cell Mol. Physiol. | volume = 289 | issue = 5 | pages = L867-74 | date = November 2005 | pmid = 15964895 | doi = 10.1152/ajplung.00455.2004 }}
  • {{cite journal | vauthors = Cingolani HE, Ennis IL | title = Sodium-hydrogen exchanger, cardiac overload, and myocardial hypertrophy | journal = Circulation | volume = 115 | issue = 9 | pages = 1090–100 | year = 2007 | pmid = 17339567 | doi = 10.1161/CIRCULATIONAHA.106.626929 }}
  • {{cite journal | vauthors = Meima ME, Mackley JR, Barber DL | title = Beyond ion translocation: structural functions of the sodium-hydrogen exchanger isoform-1 | journal = Curr. Opin. Nephrol. Hypertens. | volume = 16 | issue = 4 | pages = 365–72 | year = 2007 | pmid = 17565280 | doi = 10.1097/MNH.0b013e3281bd888d }}
  • {{cite journal | vauthors = Tse CM, Ma AI, Yang VW, Watson AJ, Levine S, Montrose MH, Potter J, Sardet C, Pouyssegur J, Donowitz M | title = Molecular cloning and expression of a cDNA encoding the rabbit ileal villus cell basolateral membrane Na+/H+ exchanger | journal = EMBO J. | volume = 10 | issue = 8 | pages = 1957–67 | year = 1991 | pmid = 1712287 | pmc = 452875 | doi = }}
  • {{cite journal | vauthors = Dudley CR, Giuffra LA, Tippett P, Kidd KK, Reeders ST | title = The Na+/H+ antiporter: a "melt" polymorphism allows regional mapping to the short arm of chromosome 1 | journal = Hum. Genet. | volume = 86 | issue = 1 | pages = 79–83 | year = 1990 | pmid = 1979310 | doi = 10.1007/bf00205179 }}
  • {{cite journal | vauthors = Sardet C, Counillon L, Franchi A, Pouysségur J | title = Growth factors induce phosphorylation of the Na+/H+ antiporter, glycoprotein of 110 kD | journal = Science | volume = 247 | issue = 4943 | pages = 723–6 | year = 1990 | pmid = 2154036 | doi = 10.1126/science.2154036 }}
  • {{cite journal | vauthors = Sardet C, Franchi A, Pouysségur J | title = Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+/H+ antiporter | journal = Cell | volume = 56 | issue = 2 | pages = 271–80 | year = 1989 | pmid = 2536298 | doi = 10.1016/0092-8674(89)90901-X }}
  • {{cite journal | vauthors = Mattei MG, Sardet C, Franchi A, Pouysségur J | title = The human amiloride-sensitive Na+/H+ antiporter: localization to chromosome 1 by in situ hybridization | journal = Cytogenet. Cell Genet. | volume = 48 | issue = 1 | pages = 6–8 | year = 1988 | pmid = 2846238 | doi = 10.1159/000132575 }}
  • {{cite journal | vauthors = Counillon L, Pouysségur J, Reithmeier RA | title = The Na+/H+ exchanger NHE-1 possesses N- and O-linked glycosylation restricted to the first N-terminal extracellular domain | journal = Biochemistry | volume = 33 | issue = 34 | pages = 10463–9 | year = 1994 | pmid = 8068684 | doi = 10.1021/bi00200a030 }}
  • {{cite journal | vauthors = Fliegel L, Dyck JR, Wang H, Fong C, Haworth RS | title = Cloning and analysis of the human myocardial Na+/H+ exchanger | journal = Mol. Cell. Biochem. | volume = 125 | issue = 2 | pages = 137–43 | year = 1993 | pmid = 8283968 | doi = 10.1007/BF00936442 }}
  • {{cite journal | vauthors = Lin X, Barber DL | title = A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 22 | pages = 12631–6 | year = 1996 | pmid = 8901634 | pmc = 38044 | doi = 10.1073/pnas.93.22.12631 }}
  • {{cite journal | vauthors = Shrode LD, Gan BS, D'Souza SJ, Orlowski J, Grinstein S | title = Topological analysis of NHE1, the ubiquitous Na+/H+ exchanger using chymotryptic cleavage | journal = Am. J. Physiol. | volume = 275 | issue = 2 Pt 1 | pages = C431-9 | year = 1998 | pmid = 9688597 | doi = }}
  • {{cite journal | vauthors = Wakabayashi S, Pang T, Su X, Shigekawa M | title = A novel topology model of the human Na(+)/H(+) exchanger isoform 1 | journal = J. Biol. Chem. | volume = 275 | issue = 11 | pages = 7942–9 | year = 2000 | pmid = 10713111 | doi = 10.1074/jbc.275.11.7942 }}
  • {{cite journal | vauthors = Garden OA, Musk P, Worthington-White DA, Dewey MJ, Rich IN | title = Silent polymorphisms within the coding region of human sodium/hydrogen exchanger isoform-1 cDNA in peripheral blood mononuclear cells of leukemia patients: A comparison with healthy controls | journal = Cancer Genet. Cytogenet. | volume = 120 | issue = 1 | pages = 37–43 | year = 2000 | pmid = 10913675 | doi = 10.1016/S0165-4608(99)00246-0 }}
  • {{cite journal | vauthors = Denker SP, Huang DC, Orlowski J, Furthmayr H, Barber DL | title = Direct binding of the Na--H exchanger NHE1 to ERM proteins regulates the cortical cytoskeleton and cell shape independently of H(+) translocation | journal = Mol. Cell | volume = 6 | issue = 6 | pages = 1425–36 | year = 2000 | pmid = 11163215 | doi = 10.1016/S1097-2765(00)00139-8 }}
  • {{cite journal | vauthors = Lehoux S, Florian JA, Berk BC | title = 14-3-3 Binding to Na+/H+ exchanger isoform-1 is associated with serum-dependent activation of Na+/H+ exchange | journal = J. Biol. Chem. | volume = 276 | issue = 19 | pages = 15794–800 | year = 2001 | pmid = 11279064 | doi = 10.1074/jbc.M100410200 }}
  • {{cite journal | vauthors = Pang T, Su X, Wakabayashi S, Shigekawa M | title = Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers | journal = J. Biol. Chem. | volume = 276 | issue = 20 | pages = 17367–72 | year = 2001 | pmid = 11350981 | doi = 10.1074/jbc.M100296200 }}
  • {{cite journal | vauthors = Yan W, Nehrke K, Choi J, Barber DL | title = The Nck-interacting kinase (NIK) phosphorylates the Na+-H+ exchanger NHE1 and regulates NHE1 activation by platelet-derived growth factor | journal = J. Biol. Chem. | volume = 276 | issue = 33 | pages = 31349–56 | year = 2001 | pmid = 11369779 | doi = 10.1074/jbc.M102679200 }}
  • {{cite journal | vauthors = Khaled AR, Moor AN, Li A, Kim K, Ferris DK, Muegge K, Fisher RJ, Fliegel L, Durum SK | title = Trophic factor withdrawal: p38 mitogen-activated protein kinase activates NHE1, which induces intracellular alkalinization | journal = Mol. Cell. Biol. | volume = 21 | issue = 22 | pages = 7545–57 | year = 2001 | pmid = 11604491 | pmc = 99926 | doi = 10.1128/MCB.21.22.7545-7557.2001 }}
  • {{cite journal | vauthors = Mailänder J, Müller-Esterl W, Dedio J | title = Human homolog of mouse tescalcin associates with Na(+)/H(+) exchanger type-1 | journal = FEBS Lett. | volume = 507 | issue = 3 | pages = 331–5 | year = 2001 | pmid = 11696366 | doi = 10.1016/S0014-5793(01)02986-6 }}
  • {{cite journal | vauthors = Shen MR, Wilkins RJ, Chou CY, Ellory JC | title = Anion exchanger isoform 2 operates in parallel with Na(+)/H(+) exchanger isoform 1 during regulatory volume decrease of human cervical cancer cells | journal = FEBS Lett. | volume = 512 | issue = 1-3 | pages = 52–8 | year = 2002 | pmid = 11852051 | doi = 10.1016/S0014-5793(01)03317-8 }}
  • {{cite journal | vauthors = Behne MJ, Meyer JW, Hanson KM, Barry NP, Murata S, Crumrine D, Clegg RW, Gratton E, Holleran WM, Elias PM, Mauro TM | title = NHE1 regulates the stratum corneum permeability barrier homeostasis. Microenvironment acidification assessed with fluorescence lifetime imaging | journal = J. Biol. Chem. | volume = 277 | issue = 49 | pages = 47399–406 | year = 2002 | pmid = 12221084 | doi = 10.1074/jbc.M204759200 }}
{{refend}}{{PDB Gallery|geneid=6548}}{{Membrane transport proteins}}{{DEFAULTSORT:Sodium-hydrogen antiporter 1}}

1 : Solute carrier family
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