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词条 SOS1
释义

  1. Function

  2. Clinical significance

  3. Interactions

  4. See also

  5. References

  6. Further reading

  7. External links

{{Infobox_gene}}Son of sevenless homolog 1 is a protein that in humans is encoded by the SOS1 gene.[1][2]

Function

RAS genes (e.g., MIM 190020) encode membrane-bound guanine nucleotide-binding proteins that function in the transduction of signals that control cell growth and differentiation. Binding of GTP activates RAS proteins, and subsequent hydrolysis of the bound GTP to GDP and phosphate inactivates signaling by these proteins. GTP binding can be catalyzed by guanine nucleotide exchange factors for RAS, and GTP hydrolysis can be accelerated by GTPase-activating proteins (GAPs). The first exchange factor to be identified for RAS was the S. cerevisiae CDC25 gene product. Genetic analysis indicated that CDC25 is essential for activation of RAS proteins. In Drosophila, the protein encoded by the 'son of sevenless' gene (Sos) contains a domain that shows sequence similarity with the catalytic domain of CDC25. Sos may act as a positive regulator of RAS by promoting guanine nucleotide exchange.[supplied by OMIM][3]

Clinical significance

Recent studies also show that mutations in Sos1 can cause Noonan syndrome[4] and hereditary gingival fibromatosis type 1.[5] Noonan syndrome has also been shown to be caused by mutations in KRAS and PTPN11 genes.[6] activators of the MAP kinase pathway.

Interactions

SOS1 has been shown to interact with:

{{div col|colwidth=20em}}
  • ABI1,[7]
  • BCR gene,[8][7]
  • CRK,[10]
  • EPS8,[8][9]
  • Epidermal growth factor receptor,[13][10][11]
  • FRS2,[16][12][13]
  • Grb2,[14][10][15][16][23][24][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31]
  • HRAS,[32][33]
  • ITSN1,[25]
  • MUC1,[34][35]
  • NCK1,[36][37][38][39]
  • PLCG1,[40][41]
  • PTPN11,[42][43]
  • SH3KBP1,[44] and
  • SHC1.[10][12][42][28] and
{{Div col end}}

See also

  • Son of Sevenless
{{Clear}}

References

1. ^{{cite journal | vauthors = Webb GC, Jenkins NA, Largaespada DA, Copeland NG, Fernandez CS, Bowtell DD | title = Mammalian homologues of the Drosophila Son of sevenless gene map to murine chromosomes 17 and 12 and to human chromosomes 2 and 14, respectively | journal = Genomics | volume = 18 | issue = 1 | pages = 14–9 | date = February 1994 | pmid = 8276400 | pmc = | doi = 10.1006/geno.1993.1421 }}
2. ^{{cite journal | vauthors = Xiao S, Wang X, Qu B, Yang M, Liu G, Bu L, Wang Y, Zhu L, Lei H, Hu L, Zhang X, Liu J, Zhao G, Kong X | title = Refinement of the locus for autosomal dominant hereditary gingival fibromatosis (GINGF) to a 3.8-cM region on 2p21 | journal = Genomics | volume = 68 | issue = 3 | pages = 247–52 | date = November 2000 | pmid = 10995566 | pmc = | doi = 10.1006/geno.2000.6285 }}
3. ^{{cite web | title = Entrez Gene: SOS1 son of sevenless homolog 1 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6654| accessdate = }}
4. ^{{cite journal | vauthors = Roberts AE, Araki T, Swanson KD, Montgomery KT, Schiripo TA, Joshi VA, Li L, Yassin Y, Tamburino AM, Neel BG, Kucherlapati RS | title = Germline gain-of-function mutations in SOS1 cause Noonan syndrome | journal = Nat. Genet. | volume = 39 | issue = 1 | pages = 70–4 | date = January 2007 | pmid = 17143285 | doi = 10.1038/ng1926 | url = | issn = }}
5. ^{{cite journal | vauthors = Hart TC, Zhang Y, Gorry MC, Hart PS, Cooper M, Marazita ML, Marks JM, Cortelli JR, Pallos D | title = A mutation in the SOS1 gene causes hereditary gingival fibromatosis type 1 | journal = Am. J. Hum. Genet. | volume = 70 | issue = 4 | pages = 943–54 | date = April 2002 | pmid = 11868160 | pmc = 379122 | doi = 10.1086/339689 | url = | issn = }}
6. ^{{cite journal | vauthors = Tartaglia M, Mehler EL, Goldberg R, Zampino G, Brunner HG, Kremer H, van der Burgt I, Crosby AH, Ion A, Jeffery S, Kalidas K, Patton MA, Kucherlapati RS, Gelb BD | title = Mutations in PTPN11, encoding the protein tyrosine phosphatase SHP-2, cause Noonan syndrome | journal = Nat. Genet. | volume = 29 | issue = 4 | pages = 465–8 | date = December 2001 | pmid = 11704759 | doi = 10.1038/ng772 | url = | issn = }}
7. ^{{cite journal | vauthors = Maru Y, Peters KL, Afar DE, Shibuya M, Witte ON, Smithgall TE | title = Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOS | journal = Mol. Cell. Biol. | volume = 15 | issue = 2 | pages = 835–42 | date = February 1995 | pmid = 7529874 | pmc = 231961 | doi = }}
8. ^1 {{cite journal | vauthors = Scita G, Nordstrom J, Carbone R, Tenca P, Giardina G, Gutkind S, Bjarnegård M, Betsholtz C, Di Fiore PP | title = EPS8 and E3B1 transduce signals from Ras to Rac | journal = Nature | volume = 401 | issue = 6750 | pages = 290–3 | date = September 1999 | pmid = 10499589 | doi = 10.1038/45822 }}
9. ^{{cite journal | vauthors = Offenhäuser N, Borgonovo A, Disanza A, Romano P, Ponzanelli I, Iannolo G, Di Fiore PP, Scita G | title = The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway | journal = Mol. Biol. Cell | volume = 15 | issue = 1 | pages = 91–8 | date = January 2004 | pmid = 14565974 | pmc = 307530 | doi = 10.1091/mbc.E03-06-0427 }}
10. ^1 {{cite journal | vauthors = Qian X, Esteban L, Vass WC, Upadhyaya C, Papageorge AG, Yienger K, Ward JM, Lowy DR, Santos E | title = The Sos1 and Sos2 Ras-specific exchange factors: differences in placental expression and signaling properties | journal = EMBO J. | volume = 19 | issue = 4 | pages = 642–54 | date = February 2000 | pmid = 10675333 | pmc = 305602 | doi = 10.1093/emboj/19.4.642 }}
11. ^{{cite journal | vauthors = Qian X, Vass WC, Papageorge AG, Anborgh PH, Lowy DR | title = N terminus of Sos1 Ras exchange factor: critical roles for the Dbl and pleckstrin homology domains | journal = Mol. Cell. Biol. | volume = 18 | issue = 2 | pages = 771–8 | date = February 1998 | pmid = 9447973 | pmc = 108788 | doi = 10.1128/mcb.18.2.771}}
12. ^1 {{cite journal | vauthors = Foehr ED, Tatavos A, Tanabe E, Raffioni S, Goetz S, Dimarco E, De Luca M, Bradshaw RA | title = Discoidin domain receptor 1 (DDR1) signaling in PC12 cells: activation of juxtamembrane domains in PDGFR/DDR/TrkA chimeric receptors | journal = FASEB J. | volume = 14 | issue = 7 | pages = 973–81 | date = May 2000 | pmid = 10783152 | doi = }}
13. ^{{cite journal | vauthors = Kouhara H, Hadari YR, Spivak-Kroizman T, Schilling J, Bar-Sagi D, Lax I, Schlessinger J | title = A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway | journal = Cell | volume = 89 | issue = 5 | pages = 693–702 | date = May 1997 | pmid = 9182757 | doi = 10.1016/s0092-8674(00)80252-4}}
14. ^1 {{cite journal | vauthors = Puil L, Liu J, Gish G, Mbamalu G, Bowtell D, Pelicci PG, Arlinghaus R, Pawson T | title = Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway | journal = EMBO J. | volume = 13 | issue = 4 | pages = 764–73 | date = February 1994 | pmid = 8112292 | pmc = 394874 | doi = }}
15. ^1 {{cite journal | vauthors = Buday L, Egan SE, Rodriguez Viciana P, Cantrell DA, Downward J | title = A complex of Grb2 adaptor protein, Sos exchange factor, and a 36-kDa membrane-bound tyrosine phosphoprotein is implicated in ras activation in T cells | journal = J. Biol. Chem. | volume = 269 | issue = 12 | pages = 9019–23 | date = March 1994 | pmid = 7510700 | doi = }}
16. ^1 {{cite journal | vauthors = Wong A, Lamothe B, Lee A, Schlessinger J, Lax I, Li A | title = FRS2 alpha attenuates FGF receptor signaling by Grb2-mediated recruitment of the ubiquitin ligase Cbl | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 10 | pages = 6684–9 | date = May 2002 | pmid = 11997436 | pmc = 124463 | doi = 10.1073/pnas.052138899 }}
17. ^{{cite journal | vauthors = Blagoev B, Kratchmarova I, Ong SE, Nielsen M, Foster LJ, Mann M | title = A proteomics strategy to elucidate functional protein-protein interactions applied to EGF signaling | journal = Nat. Biotechnol. | volume = 21 | issue = 3 | pages = 315–8 | date = March 2003 | pmid = 12577067 | doi = 10.1038/nbt790 }}
18. ^{{cite journal | vauthors = Liu SK, McGlade CJ | title = Gads is a novel SH2 and SH3 domain-containing adaptor protein that binds to tyrosine-phosphorylated Shc | journal = Oncogene | volume = 17 | issue = 24 | pages = 3073–82 | date = Dec 1998 | pmid = 9872323 | doi = 10.1038/sj.onc.1202337 }}
19. ^{{cite journal | vauthors = Oneyama C, Nakano H, Sharma SV | title = UCS15A, a novel small molecule, SH3 domain-mediated protein-protein interaction blocking drug | journal = Oncogene | volume = 21 | issue = 13 | pages = 2037–50 | date = March 2002 | pmid = 11960376 | doi = 10.1038/sj.onc.1205271 }}
20. ^{{cite journal | vauthors = Robinson A, Gibbins J, Rodríguez-Liñares B, Finan PM, Wilson L, Kellie S, Findell P, Watson SP | title = Characterization of Grb2-binding proteins in human platelets activated by Fc gamma RIIA cross-linking | journal = Blood | volume = 88 | issue = 2 | pages = 522–30 | date = July 1996 | pmid = 8695800 | doi = }}
21. ^{{cite journal | vauthors = Li N, Batzer A, Daly R, Yajnik V, Skolnik E, Chardin P, Bar-Sagi D, Margolis B, Schlessinger J | title = Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling | journal = Nature | volume = 363 | issue = 6424 | pages = 85–8 | date = May 1993 | pmid = 8479541 | doi = 10.1038/363085a0 }}
22. ^{{cite journal | vauthors = Reif K, Buday L, Downward J, Cantrell DA | title = SH3 domains of the adapter molecule Grb2 complex with two proteins in T cells: the guanine nucleotide exchange protein Sos and a 75-kDa protein that is a substrate for T cell antigen receptor-activated tyrosine kinases | journal = J. Biol. Chem. | volume = 269 | issue = 19 | pages = 14081–7 | date = May 1994 | pmid = 8188688 | doi = }}
23. ^{{cite journal | vauthors = D'Angelo G, Martini JF, Iiri T, Fantl WJ, Martial J, Weiner RI | title = 16K human prolactin inhibits vascular endothelial growth factor-induced activation of Ras in capillary endothelial cells | journal = Mol. Endocrinol. | volume = 13 | issue = 5 | pages = 692–704 | date = May 1999 | pmid = 10319320 | doi = 10.1210/mend.13.5.0280 }}
24. ^{{cite journal | vauthors = Nel AE, Gupta S, Lee L, Ledbetter JA, Kanner SB | title = Ligation of the T-cell antigen receptor (TCR) induces association of hSos1, ZAP-70, phospholipase C-gamma 1, and other phosphoproteins with Grb2 and the zeta-chain of the TCR | journal = J. Biol. Chem. | volume = 270 | issue = 31 | pages = 18428–36 | date = August 1995 | pmid = 7629168 | doi = 10.1074/jbc.270.31.18428}}
25. ^1 {{cite journal | vauthors = Tong XK, Hussain NK, de Heuvel E, Kurakin A, Abi-Jaoude E, Quinn CC, Olson MF, Marais R, Baranes D, Kay BK, McPherson PS | title = The endocytic protein intersectin is a major binding partner for the Ras exchange factor mSos1 in rat brain | journal = EMBO J. | volume = 19 | issue = 6 | pages = 1263–71 | date = March 2000 | pmid = 10716926 | pmc = 305667 | doi = 10.1093/emboj/19.6.1263 }}
26. ^{{cite journal | vauthors = Park RK, Izadi KD, Deo YM, Durden DL | title = Role of Src in the modulation of multiple adaptor proteins in FcalphaRI oxidant signaling | journal = Blood | volume = 94 | issue = 6 | pages = 2112–20 | date = September 1999 | pmid = 10477741 | doi = }}
27. ^{{cite journal | vauthors = Germani A, Romero F, Houlard M, Camonis J, Gisselbrecht S, Fischer S, Varin-Blank N | title = hSiah2 is a new Vav binding protein which inhibits Vav-mediated signaling pathways | journal = Mol. Cell. Biol. | volume = 19 | issue = 5 | pages = 3798–807 | date = May 1999 | pmid = 10207103 | pmc = 84217 | doi = }}
28. ^1 {{cite journal | vauthors = Park RK, Erdreich-Epstein A, Liu M, Izadi KD, Durden DL | title = High affinity IgG receptor activation of Src family kinases is required for modulation of the Shc-Grb2-Sos complex and the downstream activation of the nicotinamide adenine dinucleotide phosphate (reduced) oxidase | journal = J. Immunol. | volume = 163 | issue = 11 | pages = 6023–34 | date = Dec 1999 | pmid = 10570290 | doi = }}
29. ^{{cite journal | vauthors = Saci A, Liu WQ, Vidal M, Garbay C, Rendu F, Bachelot-Loza C | title = Differential effect of the inhibition of Grb2-SH3 interactions in platelet activation induced by thrombin and by Fc receptor engagement | journal = Biochem. J. | volume = 363 | issue = Pt 3 | pages = 717–25 | date = May 2002 | pmid = 11964172 | pmc = 1222524 | doi = 10.1042/0264-6021:3630717}}
30. ^{{cite journal | vauthors = Sastry L, Cao T, King CR | title = Multiple Grb2-protein complexes in human cancer cells | journal = Int. J. Cancer | volume = 70 | issue = 2 | pages = 208–13 | date = January 1997 | pmid = 9009162 | doi = 10.1002/(sici)1097-0215(19970117)70:2<208::aid-ijc12>3.0.co;2-e}}
31. ^{{cite journal | vauthors = Spivak-Kroizman T, Mohammadi M, Hu P, Jaye M, Schlessinger J, Lax I | title = Point mutation in the fibroblast growth factor receptor eliminates phosphatidylinositol hydrolysis without affecting neuronal differentiation of PC12 cells | journal = J. Biol. Chem. | volume = 269 | issue = 20 | pages = 14419–23 | date = May 1994 | pmid = 7514169 | doi = }}
32. ^{{cite journal | vauthors = Margarit SM, Sondermann H, Hall BE, Nagar B, Hoelz A, Pirruccello M, Bar-Sagi D, Kuriyan J | title = Structural evidence for feedback activation by Ras.GTP of the Ras-specific nucleotide exchange factor SOS | journal = Cell | volume = 112 | issue = 5 | pages = 685–95 | date = March 2003 | pmid = 12628188 | doi = 10.1016/s0092-8674(03)00149-1}}
33. ^{{cite journal | vauthors = Boriack-Sjodin PA, Margarit SM, Bar-Sagi D, Kuriyan J | title = The structural basis of the activation of Ras by Sos | journal = Nature | volume = 394 | issue = 6691 | pages = 337–43 | date = July 1998 | pmid = 9690470 | doi = 10.1038/28548 }}
34. ^1 {{cite journal | vauthors = Pandey P, Kharbanda S, Kufe D | title = Association of the DF3/MUC1 breast cancer antigen with Grb2 and the Sos/Ras exchange protein | journal = Cancer Res. | volume = 55 | issue = 18 | pages = 4000–3 | date = September 1995 | pmid = 7664271 | doi = }}
35. ^{{cite journal | vauthors = Schroeder JA, Thompson MC, Gardner MM, Gendler SJ | title = Transgenic MUC1 interacts with epidermal growth factor receptor and correlates with mitogen-activated protein kinase activation in the mouse mammary gland | journal = J. Biol. Chem. | volume = 276 | issue = 16 | pages = 13057–64 | date = April 2001 | pmid = 11278868 | doi = 10.1074/jbc.M011248200 }}
36. ^1 2 {{cite journal | vauthors = Okada S, Pessin JE | title = Interactions between Src homology (SH) 2/SH3 adapter proteins and the guanylnucleotide exchange factor SOS are differentially regulated by insulin and epidermal growth factor | journal = J. Biol. Chem. | volume = 271 | issue = 41 | pages = 25533–8 | date = October 1996 | pmid = 8810325 | doi = 10.1074/jbc.271.41.25533}}
37. ^{{cite journal | vauthors = Wunderlich L, Faragó A, Buday L | title = Characterization of interactions of Nck with Sos and dynamin | journal = Cell. Signal. | volume = 11 | issue = 1 | pages = 25–9 | date = January 1999 | pmid = 10206341 | doi = 10.1016/s0898-6568(98)00027-8}}
38. ^{{cite journal | vauthors = Hu Q, Milfay D, Williams LT | title = Binding of NCK to SOS and activation of ras-dependent gene expression | journal = Mol. Cell. Biol. | volume = 15 | issue = 3 | pages = 1169–74 | date = March 1995 | pmid = 7862111 | pmc = 230339 | doi = }}
39. ^{{cite journal | vauthors = Braverman LE, Quilliam LA | title = Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck | journal = J. Biol. Chem. | volume = 274 | issue = 9 | pages = 5542–9 | date = February 1999 | pmid = 10026169 | doi = 10.1074/jbc.274.9.5542}}
40. ^{{cite journal | vauthors = Kim MJ, Chang JS, Park SK, Hwang JI, Ryu SH, Suh PG | title = Direct interaction of SOS1 Ras exchange protein with the SH3 domain of phospholipase C-gamma1 | journal = Biochemistry | volume = 39 | issue = 29 | pages = 8674–82 | date = July 2000 | pmid = 10913276 | doi = 10.1021/bi992558t}}
41. ^{{cite journal | vauthors = Scholler JK, Perez-Villar JJ, O'Day K, Kanner SB | title = Engagement of the T lymphocyte antigen receptor regulates association of son-of-sevenless homologues with the SH3 domain of phospholipase Cgamma1 | journal = Eur. J. Immunol. | volume = 30 | issue = 8 | pages = 2378–87 | date = August 2000 | pmid = 10940929 | doi = 10.1002/1521-4141(2000)30:8<2378::AID-IMMU2378>3.0.CO;2-E }}
42. ^1 2 {{cite journal | vauthors = Chin H, Saito T, Arai A, Yamamoto K, Kamiyama R, Miyasaka N, Miura O | title = Erythropoietin and IL-3 induce tyrosine phosphorylation of CrkL and its association with Shc, SHP-2, and Cbl in hematopoietic cells | journal = Biochem. Biophys. Res. Commun. | volume = 239 | issue = 2 | pages = 412–7 | date = October 1997 | pmid = 9344843 | doi = 10.1006/bbrc.1997.7480 }}
43. ^{{cite journal | vauthors = Hadari YR, Kouhara H, Lax I, Schlessinger J | title = Binding of Shp2 tyrosine phosphatase to FRS2 is essential for fibroblast growth factor-induced PC12 cell differentiation | journal = Mol. Cell. Biol. | volume = 18 | issue = 7 | pages = 3966–73 | date = July 1998 | pmid = 9632781 | pmc = 108981 | doi = }}
44. ^{{cite journal | vauthors = Watanabe S, Take H, Takeda K, Yu ZX, Iwata N, Kajigaya S | title = Characterization of the CIN85 adaptor protein and identification of components involved in CIN85 complexes | journal = Biochem. Biophys. Res. Commun. | volume = 278 | issue = 1 | pages = 167–74 | date = November 2000 | pmid = 11071869 | doi = 10.1006/bbrc.2000.3760 }}

Further reading

{{Refbegin|35em}}
  • {{cite journal | vauthors = Lioubin MN, Myles GM, Carlberg K, Bowtell D, Rohrschneider LR | title = Shc, Grb2, Sos1, and a 150-kilodalton tyrosine-phosphorylated protein form complexes with Fms in hematopoietic cells. | journal = Mol. Cell. Biol. | volume = 14 | issue = 9 | pages = 5682–91 | year = 1994 | pmid = 7520523 | pmc = 359093 | doi = 10.1128/mcb.14.9.5682 }}
  • {{cite journal | vauthors = Nel AE, Gupta S, Lee L, Ledbetter JA, Kanner SB | title = Ligation of the T-cell antigen receptor (TCR) induces association of hSos1, ZAP-70, phospholipase C-gamma 1, and other phosphoproteins with Grb2 and the zeta-chain of the TCR. | journal = J. Biol. Chem. | volume = 270 | issue = 31 | pages = 18428–36 | year = 1995 | pmid = 7629168 | doi = 10.1074/jbc.270.31.18428 }}
  • {{cite journal | vauthors = Pandey P, Kharbanda S, Kufe D | title = Association of the DF3/MUC1 breast cancer antigen with Grb2 and the Sos/Ras exchange protein. | journal = Cancer Res. | volume = 55 | issue = 18 | pages = 4000–3 | year = 1995 | pmid = 7664271 | doi = }}
  • {{cite journal | vauthors = Hu Q, Milfay D, Williams LT | title = Binding of NCK to SOS and activation of ras-dependent gene expression. | journal = Mol. Cell. Biol. | volume = 15 | issue = 3 | pages = 1169–74 | year = 1995 | pmid = 7862111 | pmc = 230339 | doi = }}
  • {{cite journal | vauthors = Puil L, Liu J, Gish G, Mbamalu G, Bowtell D, Pelicci PG, Arlinghaus R, Pawson T | title = Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway. | journal = EMBO J. | volume = 13 | issue = 4 | pages = 764–73 | year = 1994 | pmid = 8112292 | pmc = 394874 | doi = }}
  • {{cite journal | vauthors = Li N, Batzer A, Daly R, Yajnik V, Skolnik E, Chardin P, Bar-Sagi D, Margolis B, Schlessinger J | title = Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling. | journal = Nature | volume = 363 | issue = 6424 | pages = 85–8 | year = 1993 | pmid = 8479541 | doi = 10.1038/363085a0 }}
  • {{cite journal | vauthors = Chardin P, Camonis JH, Gale NW, van Aelst L, Schlessinger J, Wigler MH, Bar-Sagi D | title = Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. | journal = Science | volume = 260 | issue = 5112 | pages = 1338–43 | year = 1993 | pmid = 8493579 | doi = 10.1126/science.8493579 }}
  • {{cite journal | vauthors = Sadoshima J, Izumo S | title = The heterotrimeric G q protein-coupled angiotensin II receptor activates p21 ras via the tyrosine kinase-Shc-Grb2-Sos pathway in cardiac myocytes. | journal = EMBO J. | volume = 15 | issue = 4 | pages = 775–87 | year = 1996 | pmid = 8631299 | pmc = 450276 | doi = }}
  • {{cite journal | vauthors = Feng GS, Ouyang YB, Hu DP, Shi ZQ, Gentz R, Ni J | title = Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine kinases to the Ras pathway. | journal = J. Biol. Chem. | volume = 271 | issue = 21 | pages = 12129–32 | year = 1996 | pmid = 8647802 | doi = 10.1074/jbc.271.21.12129 }}
  • {{cite journal | vauthors = Okada S, Pessin JE | title = Interactions between Src homology (SH) 2/SH3 adapter proteins and the guanylnucleotide exchange factor SOS are differentially regulated by insulin and epidermal growth factor. | journal = J. Biol. Chem. | volume = 271 | issue = 41 | pages = 25533–8 | year = 1996 | pmid = 8810325 | doi = 10.1074/jbc.271.41.25533 }}
  • {{cite journal | vauthors = Corbalan-Garcia S, Yang SS, Degenhardt KR, Bar-Sagi D | title = Identification of the mitogen-activated protein kinase phosphorylation sites on human Sos1 that regulate interaction with Grb2. | journal = Mol. Cell. Biol. | volume = 16 | issue = 10 | pages = 5674–82 | year = 1996 | pmid = 8816480 | pmc = 231567 | doi = }}
  • {{cite journal | vauthors = Sattler M, Salgia R, Shrikhande G, Verma S, Uemura N, Law SF, Golemis EA, Griffin JD | title = Differential signaling after beta1 integrin ligation is mediated through binding of CRKL to p120(CBL) and p110(HEF1). | journal = J. Biol. Chem. | volume = 272 | issue = 22 | pages = 14320–6 | year = 1997 | pmid = 9162067 | doi = 10.1074/jbc.272.22.14320 }}
  • {{cite journal | vauthors = Leprince C, Romero F, Cussac D, Vayssiere B, Berger R, Tavitian A, Camonis JH | title = A new member of the amphiphysin family connecting endocytosis and signal transduction pathways. | journal = J. Biol. Chem. | volume = 272 | issue = 24 | pages = 15101–5 | year = 1997 | pmid = 9182529 | doi = 10.1074/jbc.272.24.15101 }}
  • {{cite journal | vauthors = Kouhara H, Hadari YR, Spivak-Kroizman T, Schilling J, Bar-Sagi D, Lax I, Schlessinger J | title = A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway. | journal = Cell | volume = 89 | issue = 5 | pages = 693–702 | year = 1997 | pmid = 9182757 | doi = 10.1016/S0092-8674(00)80252-4 }}
  • {{cite journal | vauthors = Chin H, Saito T, Arai A, Yamamoto K, Kamiyama R, Miyasaka N, Miura O | title = Erythropoietin and IL-3 induce tyrosine phosphorylation of CrkL and its association with Shc, SHP-2, and Cbl in hematopoietic cells. | journal = Biochem. Biophys. Res. Commun. | volume = 239 | issue = 2 | pages = 412–7 | year = 1997 | pmid = 9344843 | doi = 10.1006/bbrc.1997.7480 }}
  • {{cite journal | vauthors = Zheng J, Chen RH, Corblan-Garcia S, Cahill SM, Bar-Sagi D, Cowburn D | title = The solution structure of the pleckstrin homology domain of human SOS1. A possible structural role for the sequential association of diffuse B cell lymphoma and pleckstrin homology domains. | journal = J. Biol. Chem. | volume = 272 | issue = 48 | pages = 30340–4 | year = 1997 | pmid = 9374522 | doi = 10.1074/jbc.272.48.30340 }}
  • {{cite journal | vauthors = Li S, Kim M, Hu YL, Jalali S, Schlaepfer DD, Hunter T, Chien S, Shyy JY | title = Fluid shear stress activation of focal adhesion kinase. Linking to mitogen-activated protein kinases. | journal = J. Biol. Chem. | volume = 272 | issue = 48 | pages = 30455–62 | year = 1997 | pmid = 9374537 | doi = 10.1074/jbc.272.48.30455 }}
  • {{cite journal | vauthors = Qian X, Vass WC, Papageorge AG, Anborgh PH, Lowy DR | title = N terminus of Sos1 Ras exchange factor: critical roles for the Dbl and pleckstrin homology domains. | journal = Mol. Cell. Biol. | volume = 18 | issue = 2 | pages = 771–8 | year = 1998 | pmid = 9447973 | pmc = 108788 | doi = 10.1128/mcb.18.2.771}}
  • {{cite journal | vauthors = Curto M, Frankel P, Carrero A, Foster DA | title = Novel recruitment of Shc, Grb2, and Sos by fibroblast growth factor receptor-1 in v-Src-transformed cells. | journal = Biochem. Biophys. Res. Commun. | volume = 243 | issue = 2 | pages = 555–60 | year = 1998 | pmid = 9480847 | doi = 10.1006/bbrc.1997.7982 }}
{{Refend}}

External links

  • [https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=noonan GeneReviews/NCBI/NIH/UW entry on Noonan syndrome]
  • http://www.noonansyndrome.org
  • http://ghr.nlm.nih.gov/gene=sos1
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