St. Charles College may refer to:

• St. Charles College (Maryland), former Catholic seminary school in Ellicott City, Maryland
• St. Charles College (Missouri), former Methodist college in St. Charles, Missouri
• St. Charles Community College, in St. Charles County, Missouri
• St. Charles College, Pietermaritzburg, private boys' high school in KwaZulu-Natal province, South Africa
• St. Charles College (Sudbury), high school in Ontario, Canada
• St Charles Catholic Sixth Form College, in the Royal Borough of Kensington and Chelsea, London, England

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