| 词条 | Streptococcus sanguinis |
| 释义 |
| color = lightgrey | name = Streptococcus sanguinis | regnum = Bacteria | phylum = Firmicutes | classis = Bacilli | ordo = Lactobacillales | familia = Streptococcaceae | genus = Streptococcus | species = S. sanguinis | binomial = Streptococcus sanguinis | binomial_authority = White and Niven 1946 }} Streptococcus sanguinis, formerly known as Streptococcus sanguis, is a Gram-positive facultative anaerobic[1] coccus species of bacteria and a member of the Viridans Streptococcus group. S. sanguinis is a normal inhabitant of the healthy human mouth where it is particularly found in dental plaque, where it modifies the environment to make it less hospitable for other strains of Streptococcus that cause cavities, such as Streptococcus mutans. PathogenicityS. sanguinis may gain entrance to the bloodstream when opportunity presents (dental cleanings and surgeries) and colonize the heart valves, particularly the mitral and aortic valves, where it is the most common cause of subacute bacterial endocarditis. For this reason, oral surgeons often prescribe a short course of antibiotics to be taken a few days before to a few days after oral surgery. Once an infection has occurred, treatment is much more complicated and generally involves the administration of several weeks of penicillin and aminoglycoside antibiotics. GenomeThe complete genomic sequence of S. sanguinis was determined in 2007 by laboratories at Virginia Commonwealth University.[2] The genome spans 2,388,435 bp and is larger than most of the other 21 streptococcal genomes that have been sequenced. The GC content of the S. sanguinis genome is 43.4% (higher than the GC contents of other streptococci). The genome encodes 2,274 predicted proteins, 61 tRNAs, and four rRNA operons. About 22% of the open reading frames are conserved hypothetical proteins (present in multiple species but having unknown functions), and approximately 645 of the predicted proteins were confirmed by mass spectrometry.[2] Natural genetic transformationS. sanguinis is naturally competent for genetic transformation.[3] Natural genetic transformation is a sexual process involving DNA transfer from one bacterial cell to another through the intervening medium, and the integration of the donor sequence into the recipient genome by homologous recombination. References1. ^{{cite journal | doi = 10.1128/IAI.73.9.6064-6074.2005 | pmid=16113327 | volume=73 | issue=9 | title=Identification of Virulence Determinants for Endocarditis in Streptococcus sanguinis by Signature-Tagged Mutagenesis | journal=Infection and Immunity | pages=6064–6074| pmc=1231064 | year=2005 | last1=Paik | first1=S. | last2=Senty | first2=L. | last3=Das | first3=S. | last4=Noe | first4=J. C. | last5=Munro | first5=C. L. | last6=Kitten | first6=T. }} 2. ^1 {{cite journal |vauthors=Xu P, Alves JM, Kitten T, Brown A, Chen Z, Ozaki LS, Manque P, Ge X, Serrano MG, Puiu D, Hendricks S, Wang Y, Chaplin MD, Akan D, Paik S, Peterson DL, Macrina FL, Buck GA|title=Genome of the opportunistic pathogen Streptococcus sanguinis|journal=J Bacteriol|date=Apr 2007|volume=189|issue=8|pages=3166–75|doi=10.1128/JB.01808-06|pmid=17277061|pmc=1855836}} 3. ^{{cite journal |vauthors=Rodriguez AM, Callahan JE, Fawcett P, Ge X, Xu P, Kitten T |title=Physiological and molecular characterization of genetic competence in Streptococcus sanguinis |journal=Mol Oral Microbiol |volume=26 |issue=2 |pages=99–116 |year=2011 |pmid=21375701 |pmc=3076142 |doi=10.1111/j.2041-1014.2011.00606.x |url=}} Further reading
External links
3 : Gram-positive bacteria|Streptococcaceae|Bacteria described in 1946 |
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