| 词条 | Suxibuzone |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 408916457 | IUPAC_name = 4-[ [4-butyl-3,5-dioxo-1,2-di(phenyl)pyrazolidin-4-yl]methoxy]-4-oxobutanoic acid | image = suxibuzone.png | tradename = | Drugs.com = {{drugs.com|international|suxibuzone}} | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = | ATC_prefix = M02 | ATC_suffix = AA22 | ATC_supplemental = {{ATCvet|M01|AA90}} | PubChem = 5362 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | UNII_Ref = {{fdacite|changed|FDA}} | UNII = 86TDZ5WP2B | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D01289 | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 1414320 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 5169 | smiles = O=C(O)CCC(=O)OCC2(C(=O)N(c1ccccc1)N(C2=O)c3ccccc3)CCCC | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C24H26N2O6/c1-2-3-16-24(17-32-21(29)15-14-20(27)28)22(30)25(18-10-6-4-7-11-18)26(23(24)31)19-12-8-5-9-13-19/h4-13H,2-3,14-17H2,1H3,(H,27,28) | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = ONWXNHPOAGOMTG-UHFFFAOYSA-N | C=24 | H=26 | N=2 | O=6 | molecular_weight = 438.47304 g/mol }}Suxibuzone is an analgesic used for joint and muscular pain. It is a prodrug of the nonsteroidal anti-inflammatory drug (NSAID) phenylbutazone,[1] and is commonly used in horses.[2] References1. ^{{cite journal | vauthors = Yasuda Y, Shindo T, Mitani N, Ishida N, Oono F, Kageyama T | title = Comparison of the absorption, excretion, and metabolism of suxibuzone and phenylbutazone in humans | journal = Journal of Pharmaceutical Sciences | volume = 71 | issue = 5 | pages = 565–72 | year = 1982 | pmid = 7097505 | doi = 10.1002/jps.2600710521 }} {{Anti-inflammatory and antirheumatic products}}{{Topical products for joint and muscular pain}}{{musculoskeletal-drug-stub}}2. ^{{cite journal | vauthors = Sabaté D, Homedes J, Salichs M, Sust M, Monreal L | title = Multicentre, controlled, randomised and blinded field study comparing efficacy of suxibuzone and phenylbutazone in lame horses | journal = Equine Veterinary Journal | volume = 41 | issue = 7 | pages = 700–5 | year = 2009 | pmid = 19927590 | doi = 10.2746/042516409X464807 }} 2 : Pyrazolidindiones|Carboxylate esters |
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