| 词条 | Adipokine |
| 释义 |
The adipokines, or adipocytokines (Greek adipo-, fat; cytos-, cell; and -kinos, movement) are cytokines (cell signaling proteins) secreted by adipose tissue. The first adipokine to be discovered was leptin in 1994.[1] Since that time, hundreds of adipokines have been discovered.[2] Members include:
In addition, interleukin 8 (IL-8), interleukin 10 (IL-10), interferon gamma (IFN-γ) and inducible protein 10 (IP-10 or CXCL10) have been shown to be associated with excessive body weight.[7] Notes1. ^{{cite journal |vauthors=Conde J, Scotece M, Gómez R, López V, Gómez-Reino JJ, Lago F, Gualillo O | title=Adipokines: BioFactors from white adipose tissue. A complex hub among inflammation, metabolism, and immunity | journal= BioFactors | volume=37 | issue=6 | year=2011 | pages=413–420 | doi=10.1002/biof.185 | pmid=22038756}} 2. ^{{cite journal |vauthors=Lehr S, Hartwig S, Sell H | title=Adipokines: a treasure trove for the discovery of biomarkers for metabolic disorders | journal=Proteomics: Clinical Applications | volume=6 | issue=1-2 | year=2012 | pages=91–101 | doi=10.1002/prca.201100052 | pmid=22213627}} 3. ^Guo L, Li Q, Wang W, Yu P, Pan H, Li P, Sun Y, Zhang J. Endocr Res. 2009;34(4):142-54. 4. ^MacDougald1, Ormond A. and Burant, Charles F. (September 2007) "The Rapidly Expanding Family of Adipokines" Cell Metabolism 6: pp. 159-161 5. ^Monzillo, Lais U. (2003) "Effect of Lifestyle Modification on Adipokine Levels in Obese Subjects with Insulin Resistance" Obesity Research 11(9): pp. 1048-1054 6. ^Christiansen T., Richelsen B., and Bruun J.M. (2005) "Monocyte chemoattractant protein-1 is produced in isolated adipocytes, associated with adiposity and reduced after weight loss in morbid obese subjects" International Journal of Obesity 29: pp. 146–150 7. ^{{cite journal|last=Sharabiani|first=MT|author2=Vermeulen R|author3=Scoccianti C|author4=Hosnijeh FS|author5=Minelli L|author6=Sacerdote C|author7=Palli D|author8=Krogh V|author9= Tumino R|author10=Chiodini P|author11= Panico S|author12=Vineis P.|title=Immunologic profile of excessive body weight|journal=Biomarkers|date=May 2011|volume=16|issue=3|pages=243–51|doi=10.3109/1354750X.2010.547948|pmid=21506696}} External links
1 : Cytokines |
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