词条 | Technetium (99mTc) fanolesomab |
释义 |
| Verifiedfields = changed | verifiedrevid = 470478210 | drug_name = Technetium (99mTc) fanolesomab | type = mab | mab_type = mab | source = o | target = CD15 | tradename = NeutroSpec | pregnancy_category = | legal_status = | routes_of_administration = Intravenous | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = none | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 225239-31-6 | ATC_prefix = none | ATC_suffix = | ATC_supplemental = | PubChem = | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | chemical_formula = | molecular_weight = }} Technetium (99mTc) fanolesomab (trade name NeutroSpec, manufactured by Palatin Technologies) is a mouse monoclonal antibody formerly used to aid in the diagnosis of appendicitis. It is labeled with a radioisotope, technetium-99m (99mTc). History and useNeutroSpec was approved by the U.S. Food and Drug Administration (FDA) in June 2004 for imaging of patients with symptoms of appendicitis. It consisted of an intact murine (mouse) IgM monoclonal antibody against human CD15, labeled with technetium-99m so as to be visible on a gamma camera image. Since anti-CD15 antibodies bind selectively to white blood cells such as neutrophils, it could be used to localize the site of an infection. Deaths and associated recallThe FDA received reports from Palatin of 2 deaths and 15 life-threatening adverse events in patients who had received NeutroSpec.
Marketing of the product was suspended in December 2005. References1. ^{{cite press release | url = http://www.fda.gov/cder/drug/advisory/technetium99.htm | title = FDA Public Health Advisory: Suspended Marketing of NeutroSpec (Technetium (99m Tc) fanolesomab) | date = December 19, 2005 | accessdate = 2007-11-27 | publisher = U.S. Food and Drug Administration}}
External links
5 : Monoclonal antibodies|Radiocontrast agents|Withdrawn drugs|Technetium compounds|Technetium-99m |
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