| 词条 | Technetium (99mTc) nofetumomab merpentan |
| 释义 |
| Verifiedfields = changed | verifiedrevid = 470478313 | image = Technetium-99m nofetumomab merpentan skeletal.svg | drug_name = Technetium (99mTc) nofetumomab merpentan | type = mab | mab_type = Fab | source = o | target = | tradename = Verluma | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = 10.5 hours | excretion = renal (64%) | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = none | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 165942-79-0 | ATC_prefix = none | ATC_suffix = | PubChem = | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | chemical_formula = | molecular_weight = }}Technetium (99mTc) nofetumomab merpentan (trade name Verluma) is a mouse monoclonal antibody derivative used in the diagnosis of lung cancer,[1] gastrointestinal, breast, ovary, pancreas, kidney, cervix, and bladder carcinoma.[2] The antibody part, nofetumomab, is attached to the chelator merpentan, which links it to the radioisotope technetium-99m (99mTc).[3] NofetumomabNofetumomab is an antibody fragment that recognises the pancarcinoma glycoprotein antigen EpCAM.[4] and/or CD20/MS4A1[5] It is the Fab part of murine MAb NR-LU-10.[6] MerpentanThe chelator part : merpentan is a phenthioate ligand, 2,3,5,6-tetrafluorophenyl-4,5-bis-5-[1-ethoxyethyl]-thioacetoamidopentanoate.[6] PhenthioatePhenthioate is an insecticide (Cidial) = O,o-dimethyl-S-(carbethoxy-phenylmethyl)dithiophosphate[7] References1. ^{{cite journal|pmid=10634533|year=2000|last1=Straka|first1=MR|last2=Joyce|first2=JM|last3=Myers|first3=DT|title=Tc-99m nofetumomab merpentan complements an equivocal bone scan for detecting skeletal metastatic disease from lung cancer|volume=25|issue=1|pages=54–5|journal=Clinical nuclear medicine|doi=10.1097/00003072-200001000-00013}} {{Monoclonals for tumors}}{{DEFAULTSORT:Technetium (99mtc) Nofetumomab Merpentan}}{{monoclonal-antibody-stub}}{{antineoplastic-drug-stub}}2. ^{{cite journal|pmid=9298295|year=1997|last1=Breitz|first1=HB|last2=Tyler|first2=A|last3=Bjorn|first3=MJ|last4=Lesley|first4=T|last5=Weiden|first5=PL|title=Clinical experience with Tc-99m nofetumomab merpentan (Verluma) radioimmunoscintigraphy|volume=22|issue=9|pages=615–20|journal=Clinical nuclear medicine|doi=10.1097/00003072-199709000-00007}} 3. ^WHO Drug Information 4. ^[https://books.google.co.uk/books?id=fF8d3eZ6SZ8C&pg=PA533&lpg=PA533&dq=nofetumomab+-merpentan&source=bl&ots=-uBFQaAY2i&sig=FGgu4DUYNcvuzsJjUg-wlgMB69c&hl=en&sa=X&ved=0ahUKEwj2uurWiNjKAhXHbRQKHfofDVo4FBDoAQgyMAM#v=onepage&q=nofetumomab%20-merpentan&f=false Molecular Biology of B Cells. p533] 5. ^technetium (99mTc) nofetumomab merpentan (TAB-711) 6. ^1 Monoclonal Antibody Radionuclide Test Kits 7. ^Insecticidal composition and method utilizing phosphoric acid phenylsulphonamide esters US 3934010 A 2 : Technetium compounds|Technetium-99m |
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