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词条 Testicular receptor 2
释义

  1. Interactions

  2. See also

  3. References

  4. Further reading

{{Infobox_gene}}

The testicular receptor 2 (TR2) also known as NR2C1 (nuclear receptor subfamily 2, group C, member 1) is protein that in humans is encoded by the NR2C1 gene.[1][2] TR2 is a member of the nuclear receptor family of transcription factors.

Interactions

Testicular receptor 2 has been shown to interact with:

  • Androgen receptor,[3]
  • Estrogen receptor alpha,[4]
  • HDAC3,[5][6][7] and
  • HDAC4.[6][7]

See also

  • Testicular receptor

References

1. ^{{cite web | title = Entrez Gene: NR2C1 nuclear receptor subfamily 2, group C, member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7181| accessdate = }}
2. ^{{cite journal | vauthors = Chang C, Kokontis J, Acakpo-Satchivi L, Liao S, Takeda H, Chang Y | title = Molecular cloning of new human TR2 receptors: a class of steroid receptor with multiple ligand-binding domains | journal = Biochemical and Biophysical Research Communications | volume = 165 | issue = 2 | pages = 735–41 | date = Dec 1989 | pmid = 2597158 | doi = 10.1016/S0006-291X(89)80028-2 }}
3. ^{{cite journal | vauthors = Mu X, Chang C | title = TR2 orphan receptor functions as negative modulator for androgen receptor in prostate cancer cells PC-3 | journal = The Prostate | volume = 57 | issue = 2 | pages = 129–33 | date = Oct 2003 | pmid = 12949936 | doi = 10.1002/pros.10282 }}
4. ^{{cite journal | vauthors = Hu YC, Shyr CR, Che W, Mu XM, Kim E, Chang C | title = Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor | journal = The Journal of Biological Chemistry | volume = 277 | issue = 37 | pages = 33571–9 | date = Sep 2002 | pmid = 12093804 | doi = 10.1074/jbc.M203531200 }}
5. ^{{cite journal | vauthors = Li G, Franco PJ, Wei LN | title = Identification of histone deacetylase-3 domains that interact with the orphan nuclear receptor TR2 | journal = Biochemical and Biophysical Research Communications | volume = 310 | issue = 2 | pages = 384–90 | date = Oct 2003 | pmid = 14521922 | doi = 10.1016/j.bbrc.2003.08.145 }}
6. ^1 {{cite journal | vauthors = Franco PJ, Li G, Wei LN | title = Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase | journal = Molecular and Cellular Endocrinology | volume = 206 | issue = 1-2 | pages = 1–12 | date = Aug 2003 | pmid = 12943985 | doi = 10.1016/S0303-7207(03)00254-5 }}
7. ^1 {{cite journal | vauthors = Franco PJ, Farooqui M, Seto E, Wei LN | title = The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases | journal = Molecular Endocrinology | volume = 15 | issue = 8 | pages = 1318–28 | date = Aug 2001 | pmid = 11463856 | doi = 10.1210/mend.15.8.0682 }}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Chang C, Kokontis J | title = Identification of a new member of the steroid receptor super-family by cloning and sequence analysis | journal = Biochemical and Biophysical Research Communications | volume = 155 | issue = 2 | pages = 971–7 | date = Sep 1988 | pmid = 3421977 | doi = 10.1016/S0006-291X(88)80591-6 }}
  • {{cite journal | vauthors = Lin DL, Wu SQ, Chang C | title = The genomic structure and chromosomal location of the human TR2 orphan receptor, a member of the steroid receptor superfamily | journal = Endocrine | volume = 8 | issue = 2 | pages = 123–34 | date = Apr 1998 | pmid = 9704569 | doi = 10.1385/ENDO:8:2:123 }}
  • {{cite journal | vauthors = Lee CH, Chinpaisal C, Wei LN | title = A novel nuclear receptor heterodimerization pathway mediated by orphan receptors TR2 and TR4 | journal = The Journal of Biological Chemistry | volume = 273 | issue = 39 | pages = 25209–15 | date = Sep 1998 | pmid = 9737983 | doi = 10.1074/jbc.273.39.25209 }}
  • {{cite journal | vauthors = Lee CH, Chinpaisal C, Wei LN | title = Cloning and characterization of mouse RIP140, a corepressor for nuclear orphan receptor TR2 | journal = Molecular and Cellular Biology | volume = 18 | issue = 11 | pages = 6745–55 | date = Nov 1998 | pmid = 9774688 | pmc = 109258 | doi = 10.1128/mcb.18.11.6745}}
  • {{cite journal | vauthors = Yu Z, Lee CH, Chinpaisal C, Wei LN | title = A constitutive nuclear localization signal from the second zinc-finger of orphan nuclear receptor TR2 | journal = The Journal of Endocrinology | volume = 159 | issue = 1 | pages = 53–60 | date = Oct 1998 | pmid = 9795341 | doi = 10.1677/joe.0.1590053 }}
  • {{cite journal | vauthors = Franco PJ, Farooqui M, Seto E, Wei LN | title = The orphan nuclear receptor TR2 interacts directly with both class I and class II histone deacetylases | journal = Molecular Endocrinology | volume = 15 | issue = 8 | pages = 1318–28 | date = Aug 2001 | pmid = 11463856 | doi = 10.1210/mend.15.8.0682 }}
  • {{cite journal | vauthors = Tanabe O, Katsuoka F, Campbell AD, Song W, Yamamoto M, Tanimoto K, Engel JD | title = An embryonic/fetal beta-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer | journal = The EMBO Journal | volume = 21 | issue = 13 | pages = 3434–42 | date = Jul 2002 | pmid = 12093744 | pmc = 126089 | doi = 10.1093/emboj/cdf340 }}
  • {{cite journal | vauthors = Hu YC, Shyr CR, Che W, Mu XM, Kim E, Chang C | title = Suppression of estrogen receptor-mediated transcription and cell growth by interaction with TR2 orphan receptor | journal = The Journal of Biological Chemistry | volume = 277 | issue = 37 | pages = 33571–9 | date = Sep 2002 | pmid = 12093804 | doi = 10.1074/jbc.M203531200 }}
  • {{cite journal | vauthors = Inui S, Lee YF, Chang E, Shyr CR, Chang C | title = Differential and bi-directional regulation between TR2/TR4 orphan nuclear receptors and a specific ligand mediated-peroxisome proliferator-activated receptor alpha in human HaCaT keratinocytes | journal = Journal of Dermatological Science | volume = 31 | issue = 1 | pages = 65–71 | date = Feb 2003 | pmid = 12615366 | doi = 10.1016/S0923-1811(02)00152-4 }}
  • {{cite journal | vauthors = Franco PJ, Li G, Wei LN | title = Interaction of nuclear receptor zinc finger DNA binding domains with histone deacetylase | journal = Molecular and Cellular Endocrinology | volume = 206 | issue = 1-2 | pages = 1–12 | date = Aug 2003 | pmid = 12943985 | doi = 10.1016/S0303-7207(03)00254-5 }}
  • {{cite journal | vauthors = Mu X, Chang C | title = TR2 orphan receptor functions as negative modulator for androgen receptor in prostate cancer cells PC-3 | journal = The Prostate | volume = 57 | issue = 2 | pages = 129–33 | date = Oct 2003 | pmid = 12949936 | doi = 10.1002/pros.10282 }}
  • {{cite journal | vauthors = Li G, Franco PJ, Wei LN | title = Identification of histone deacetylase-3 domains that interact with the orphan nuclear receptor TR2 | journal = Biochemical and Biophysical Research Communications | volume = 310 | issue = 2 | pages = 384–90 | date = Oct 2003 | pmid = 14521922 | doi = 10.1016/j.bbrc.2003.08.145 }}
  • {{cite journal | vauthors = Lin YL, Wang YH, Lee HJ | title = Transcriptional regulation of the human TR2 orphan receptor gene by nuclear factor 1-A | journal = Biochemical and Biophysical Research Communications | volume = 350 | issue = 2 | pages = 430–6 | date = Nov 2006 | pmid = 17010934 | doi = 10.1016/j.bbrc.2006.09.061 }}
{{refend}}{{gene-12-stub}}{{Transcription factors|g2}}

2 : Intracellular receptors|Transcription factors
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