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词条 TGFB1I1
释义

  1. Interactions

  2. Model organisms

  3. See also

  4. References

  5. Further reading

  6. External links

{{Infobox_gene}}Transforming growth factor beta-1-induced transcript 1 protein is a protein that in humans is encoded by the TGFB1I1 gene.[1][2]

Interactions

TGFB1I1 has been shown to interact with:

{{div col|colwidth=20em}}
  • Androgen receptor,[3][4]
  • Dopamine transporter[5]
  • Hsp27,[6]
  • PTK2B,[1][3][9]
  • PTK2,[1][7][8] and
  • PTPN12.[9]
{{Div col end}}

Model organisms

Model organisms have been used in the study of TGFB1I1 function. A conditional knockout mouse line called Tgfb1i1tm1b(KOMP)Wtsi was generated at the Wellcome Trust Sanger Institute.[10] Male and female animals underwent a standardized phenotypic screen[11] to determine the effects of deletion.[12][13][14][15] Additional screens performed: - In-depth immunological phenotyping[16]{{clear|left}}

See also

  • Transcription coregulator

References

1. ^1 2 {{cite journal | vauthors = Matsuya M, Sasaki H, Aoto H, Mitaka T, Nagura K, Ohba T, Ishino M, Takahashi S, Suzuki R, Sasaki T | title = Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesions | journal = The Journal of Biological Chemistry | volume = 273 | issue = 2 | pages = 1003–14 | date = Jan 1998 | pmid = 9422762 | pmc = | doi = 10.1074/jbc.273.2.1003 }}
2. ^{{cite journal | vauthors = Fujimoto N, Yeh S, Kang HY, Inui S, Chang HC, Mizokami A, Chang C | title = Cloning and characterization of androgen receptor coactivator, ARA55, in human prostate | journal = The Journal of Biological Chemistry | volume = 274 | issue = 12 | pages = 8316–21 | date = Mar 1999 | pmid = 10075738 | pmc = | doi = 10.1074/jbc.274.12.8316 }}
3. ^1 {{cite journal |vauthors=Wang X, Yang Y, Guo X, Sampson ER, Hsu CL, Tsai MY, Yeh S, Wu G, Guo Y, Chang C |title=Suppression of androgen receptor transactivation by Pyk2 via interaction and phosphorylation of the ARA55 coregulator |journal=The Journal of Biological Chemistry |volume=277 |issue=18 |pages=15426–31 |date=May 2002 |pmid=11856738 |doi=10.1074/jbc.M111218200}}
4. ^{{cite journal |vauthors=He B, Minges JT, Lee LW, Wilson EM |title=The FXXLF motif mediates androgen receptor-specific interactions with coregulators |journal=The Journal of Biological Chemistry |volume=277 |issue=12 |pages=10226–35 |date=Mar 2002 |pmid=11779876 |doi=10.1074/jbc.M111975200}}
5. ^{{cite journal |vauthors=Carneiro AM, Ingram SL, Beaulieu JM, Sweeney A, Amara SG, Thomas SM, Caron MG, Torres GE |title=The multiple LIM domain-containing adaptor protein Hic-5 synaptically colocalizes and interacts with the dopamine transporter |journal=The Journal of Neuroscience |volume=22 |issue=16 |pages=7045–54 |date=Aug 2002 |pmid=12177201 |doi= |url=http://www.jneurosci.org/content/22/16/7045.full}}
6. ^{{cite journal |vauthors=Jia Y, Ransom RF, Shibanuma M, Liu C, Welsh MJ, Smoyer WE |title=Identification and characterization of hic-5/ARA55 as an hsp27 binding protein |journal=The Journal of Biological Chemistry |volume=276 |issue=43 |pages=39911–8 |date=Oct 2001 |pmid=11546764 |doi=10.1074/jbc.M103510200}}
7. ^1 {{cite journal |vauthors=Thomas SM, Hagel M, Turner CE |title=Characterization of a focal adhesion protein, Hic-5, that shares extensive homology with paxillin |journal=Journal of Cell Science |volume=112 |issue= 2|pages=181–90 |date=Jan 1999 |pmid=9858471 |doi=}}
8. ^{{cite journal |vauthors=Nishiya N, Tachibana K, Shibanuma M, Mashimo JI, Nose K |title=Hic-5-reduced cell spreading on fibronectin: competitive effects between paxillin and Hic-5 through interaction with focal adhesion kinase |journal=Molecular and Cellular Biology |volume=21 |issue=16 |pages=5332–45 |date=Aug 2001 |pmid=11463817 |pmc=87257 |doi=10.1128/MCB.21.16.5332-5345.2001}}
9. ^{{cite journal |vauthors=Nishiya N, Iwabuchi Y, Shibanuma M, Côté JF, Tremblay ML, Nose K |title=Hic-5, a paxillin homologue, binds to the protein-tyrosine phosphatase PEST (PTP-PEST) through its LIM 3 domain |journal=The Journal of Biological Chemistry |volume=274 |issue=14 |pages=9847–53 |date=Apr 1999 |pmid=10092676 |doi=10.1074/jbc.274.14.9847}}
10. ^{{cite journal |title=The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice |author=Gerdin AK |year=2010 |journal=Acta Ophthalmologica|volume=88 |pages=925–7|doi=10.1111/j.1755-3768.2010.4142.x }}
11. ^1 {{cite web |url=http://www.mousephenotype.org/data/search?q=Tgfb1i1#fq=**&facet=gene |title=International Mouse Phenotyping Consortium}}
12. ^{{cite journal | vauthors = Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A | title = A conditional knockout resource for the genome-wide study of mouse gene function | journal = Nature | volume = 474 | issue = 7351 | pages = 337–42 | date = Jun 2011 | pmid = 21677750 | pmc = 3572410 | doi = 10.1038/nature10163 }}
13. ^{{cite journal | vauthors = Dolgin E | title = Mouse library set to be knockout | journal = Nature | volume = 474 | issue = 7351 | pages = 262–3 | date = Jun 2011 | pmid = 21677718 | doi = 10.1038/474262a }}
14. ^{{cite journal | vauthors = Collins FS, Rossant J, Wurst W | title = A mouse for all reasons | journal = Cell | volume = 128 | issue = 1 | pages = 9–13 | date = Jan 2007 | pmid = 17218247 | doi = 10.1016/j.cell.2006.12.018 }}
15. ^{{cite journal | vauthors = White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP | title = Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes | journal = Cell | volume = 154 | issue = 2 | pages = 452–64 | date = Jul 2013 | pmid = 23870131 | pmc = 3717207 | doi = 10.1016/j.cell.2013.06.022 }}
16. ^1 {{cite web |url= http://www.immunophenotyping.org/data/search?keys=Tgfb1i1&field_gene_construct_tid=All |title=Infection and Immunity Immunophenotyping (3i) Consortium}}

Further reading

{{Refbegin | 2}}
  • {{cite journal | vauthors = Yeh S, Sampson ER, Lee DK, Kim E, Hsu CL, Chen YL, Chang HC, Altuwaijri S, Huang KE, Chang C | title = Functional analysis of androgen receptor N-terminal and ligand binding domain interacting coregulators in prostate cancer | journal = Journal of the Formosan Medical Association = Taiwan Yi Zhi | volume = 99 | issue = 12 | pages = 885–94 | date = Dec 2000 | pmid = 11155740 | doi = }}
  • {{cite journal | vauthors = Heitzer MD, DeFranco DB | title = Hic-5/ARA55: a prostate stroma-specific AR coactivator | journal = Steroids | volume = 72 | issue = 2 | pages = 218–20 | date = Feb 2007 | pmid = 17166536 | doi = 10.1016/j.steroids.2006.11.010 }}
  • {{cite journal | vauthors = Wilson SE, Lloyd SA | title = Epidermal growth factor and its receptor, basic fibroblast growth factor, transforming growth factor beta-1, and interleukin-1 alpha messenger RNA production in human corneal endothelial cells | journal = Investigative Ophthalmology & Visual Science | volume = 32 | issue = 10 | pages = 2747–56 | date = Sep 1991 | pmid = 1716619 | doi = }}
  • {{cite journal | vauthors = Shibanuma M, Mashimo J, Kuroki T, Nose K | title = Characterization of the TGF beta 1-inducible hic-5 gene that encodes a putative novel zinc finger protein and its possible involvement in cellular senescence | journal = The Journal of Biological Chemistry | volume = 269 | issue = 43 | pages = 26767–74 | date = Oct 1994 | pmid = 7929412 | doi = }}
  • {{cite journal | vauthors = Shibanuma M, Mochizuki E, Maniwa R, Mashimo J, Nishiya N, Imai S, Takano T, Oshimura M, Nose K | title = Induction of senescence-like phenotypes by forced expression of hic-5, which encodes a novel LIM motif protein, in immortalized human fibroblasts | journal = Molecular and Cellular Biology | volume = 17 | issue = 3 | pages = 1224–35 | date = Mar 1997 | pmid = 9032249 | pmc = 231847 | doi = 10.1128/mcb.17.3.1224}}
  • {{cite journal | vauthors = Fujita H, Kamiguchi K, Cho D, Shibanuma M, Morimoto C, Tachibana K | title = Interaction of Hic-5, A senescence-related protein, with focal adhesion kinase | journal = The Journal of Biological Chemistry | volume = 273 | issue = 41 | pages = 26516–21 | date = Oct 1998 | pmid = 9756887 | doi = 10.1074/jbc.273.41.26516 }}
  • {{cite journal | vauthors = Thomas SM, Hagel M, Turner CE | title = Characterization of a focal adhesion protein, Hic-5, that shares extensive homology with paxillin | journal = Journal of Cell Science | volume = 112 | issue = 2 | pages = 181–90 | date = Jan 1999 | pmid = 9858471 | doi = }}
  • {{cite journal | vauthors = Nishiya N, Iwabuchi Y, Shibanuma M, Côté JF, Tremblay ML, Nose K | title = Hic-5, a paxillin homologue, binds to the protein-tyrosine phosphatase PEST (PTP-PEST) through its LIM 3 domain | journal = The Journal of Biological Chemistry | volume = 274 | issue = 14 | pages = 9847–53 | date = Apr 1999 | pmid = 10092676 | doi = 10.1074/jbc.274.14.9847 }}
  • {{cite journal | vauthors = Turner CE, Brown MC, Perrotta JA, Riedy MC, Nikolopoulos SN, McDonald AR, Bagrodia S, Thomas S, Leventhal PS | title = Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling | journal = The Journal of Cell Biology | volume = 145 | issue = 4 | pages = 851–63 | date = May 1999 | pmid = 10330411 | pmc = 2133183 | doi = 10.1083/jcb.145.4.851 }}
  • {{cite journal | vauthors = Liu S, Thomas SM, Woodside DG, Rose DM, Kiosses WB, Pfaff M, Ginsberg MH | title = Binding of paxillin to alpha4 integrins modifies integrin-dependent biological responses | journal = Nature | volume = 402 | issue = 6762 | pages = 676–81 | date = Dec 1999 | pmid = 10604475 | doi = 10.1038/45264 }}
  • {{cite journal | vauthors = Yang L, Guerrero J, Hong H, DeFranco DB, Stallcup MR | title = Interaction of the tau2 transcriptional activation domain of glucocorticoid receptor with a novel steroid receptor coactivator, Hic-5, which localizes to both focal adhesions and the nuclear matrix | journal = Molecular Biology of the Cell | volume = 11 | issue = 6 | pages = 2007–18 | date = Jun 2000 | pmid = 10848625 | pmc = 14899 | doi = 10.1091/mbc.11.6.2007 }}
  • {{cite journal | vauthors = Oda A, Ochs HD, Lasky LA, Spencer S, Ozaki K, Fujihara M, Handa M, Ikebuchi K, Ikeda H | title = CrkL is an adapter for Wiskott-Aldrich syndrome protein and Syk | journal = Blood | volume = 97 | issue = 9 | pages = 2633–9 | date = May 2001 | pmid = 11313252 | doi = 10.1182/blood.V97.9.2633 }}
  • {{cite journal | vauthors = Nishiya N, Tachibana K, Shibanuma M, Mashimo JI, Nose K | title = Hic-5-reduced cell spreading on fibronectin: competitive effects between paxillin and Hic-5 through interaction with focal adhesion kinase | journal = Molecular and Cellular Biology | volume = 21 | issue = 16 | pages = 5332–45 | date = Aug 2001 | pmid = 11463817 | pmc = 87257 | doi = 10.1128/MCB.21.16.5332-5345.2001 }}
  • {{cite journal | vauthors = Jia Y, Ransom RF, Shibanuma M, Liu C, Welsh MJ, Smoyer WE | title = Identification and characterization of hic-5/ARA55 as an hsp27 binding protein | journal = The Journal of Biological Chemistry | volume = 276 | issue = 43 | pages = 39911–8 | date = Oct 2001 | pmid = 11546764 | doi = 10.1074/jbc.M103510200 }}
  • {{cite journal | vauthors = Ting HJ, Yeh S, Nishimura K, Chang C | title = Supervillin associates with androgen receptor and modulates its transcriptional activity | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 99 | issue = 2 | pages = 661–6 | date = Jan 2002 | pmid = 11792840 | pmc = 117362 | doi = 10.1073/pnas.022469899 }}
  • {{cite journal | vauthors = Denhez F, Wilcox-Adelman SA, Baciu PC, Saoncella S, Lee S, French B, Neveu W, Goetinck PF | title = Syndesmos, a syndecan-4 cytoplasmic domain interactor, binds to the focal adhesion adaptor proteins paxillin and Hic-5 | journal = The Journal of Biological Chemistry | volume = 277 | issue = 14 | pages = 12270–4 | date = Apr 2002 | pmid = 11805099 | doi = 10.1074/jbc.M110291200 }}
  • {{cite journal | vauthors = Wang X, Yang Y, Guo X, Sampson ER, Hsu CL, Tsai MY, Yeh S, Wu G, Guo Y, Chang C | title = Suppression of androgen receptor transactivation by Pyk2 via interaction and phosphorylation of the ARA55 coregulator | journal = The Journal of Biological Chemistry | volume = 277 | issue = 18 | pages = 15426–31 | date = May 2002 | pmid = 11856738 | doi = 10.1074/jbc.M111218200 }}
{{Refend}}

External links

  • {{MeshName|TGFB1I1+protein,+human|3=TGFB1I1 protein, human}}
  • {{NURSA|C148}}
{{NLM content}}{{Transcription coregulators}}{{DEFAULTSORT:Tgfb1i1}}

2 : Gene expression|Transcription coregulators
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