“TGF beta 2”的意思、由来-开放百科全书

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TGF beta 2

释义

Further reading

Transforming growth factor-beta 2 (TGF-β2) is a secreted protein known as a cytokine that performs many cellular functions and has a vital role during embryonic development (alternative names: Glioblastoma-derived T-cell suppressor factor, G-TSF, BSC-1 cell growth inhibitor, Polyergin, Cetermin). It is an extracellular glycosylated protein. It is known to suppress the effects of interleukin dependent T-cell tumors. There are two named isoforms of this protein, created by alternative splicing of the same gene.

{{cite journal | vauthors=Clark DA, Coker R |title=Transforming growth factor-beta (TGF-beta). |journal=Int. J. Biochem. Cell Biol. |volume=30 |issue= 3 |pages= 293–8 |year= 1998 |pmid= 9611771 |doi=10.1016/S1357-2725(97)00128-3 }}
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{{cite journal | vauthors=Philip A, Bostedt L, Stigbrand T, O'Connor-McCourt MD |title=Binding of transforming growth factor-beta (TGF-beta) to pregnancy zone protein (PZP). Comparison to the TGF-beta-alpha 2-macroglobulin interaction. |journal=Eur. J. Biochem. |volume=221 |issue= 2 |pages= 687–93 |year= 1994 |pmid= 7513640 |doi=10.1111/j.1432-1033.1994.tb18781.x }}
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{{cite journal | vauthors=López-Casillas F, Payne HM, Andres JL, Massagué J |title=Betaglycan can act as a dual modulator of TGF-beta access to signaling receptors: mapping of ligand binding and GAG attachment sites. |journal=J. Cell Biol. |volume=124 |issue= 4 |pages= 557–68 |year= 1994 |pmid= 8106553 |doi=10.1083/jcb.124.4.557 | pmc=2119924 }}
{{cite journal | vauthors=Fromigué O, Marie PJ, Lomri A |title=Bone morphogenetic protein-2 and transforming growth factor-beta2 interact to modulate human bone marrow stromal cell proliferation and differentiation. |journal=J. Cell. Biochem. |volume=68 |issue= 4 |pages= 411–26 |year= 1998 |pmid= 9493905 |doi=10.1002/(SICI)1097-4644(19980315)68:4<411::AID-JCB2>3.0.CO;2-T }}
{{cite journal |vauthors=Mori T, Kawara S, Shinozaki M, etal |title=Role and interaction of connective tissue growth factor with transforming growth factor-beta in persistent fibrosis: A mouse fibrosis model. |journal=J. Cell. Physiol. |volume=181 |issue= 1 |pages= 153–9 |year= 1999 |pmid= 10457363 |doi= 10.1002/(SICI)1097-4652(199910)181:1<153::AID-JCP16>3.0.CO;2-K }}

2 : Proteins|TGFβ domain

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