| 词条 | Thialbarbital |
| 释义 |
| Verifiedfields = changed | verifiedrevid = 470606170 | IUPAC_name = 5-allyl-5-cyclohex-2-en-1-yl-2-thioxodihydropyrimidine-4,6(1H,5H)-dione | image = Thialbarbital.svg | width = 100 | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = Schedule IV | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 3546-29-0 | ATC_prefix = none | ATC_suffix = | PubChem = 3032306 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 2104657 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 2297316 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = ENV72C33QD | C=13 | H=16 | N=2 | O=2 | S=1 | molecular_weight = 264.344 g/mol | smiles = O=C1NC(=S)NC(=O)C1(C2/C=C\\CCC2)C\\C=C | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C13H16N2O2S/c1-2-8-13(9-6-4-3-5-7-9)10(16)14-12(18)15-11(13)17/h2,4,6,9H,1,3,5,7-8H2,(H2,14,15,16,17,18) | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = PXLVRFQEBVNJOH-UHFFFAOYSA-N | synonyms = Kemithal, 5-(1-cyclohex-2-enyl)-5-prop-2-enyl-2-sulfanylidene-1,3-diazinane-4,6-dione }}Thialbarbital (Intranarcon) is a barbiturate derivative invented in the 1960s. It has sedative effects, and was used primarily for induction in surgical anaesthesia. [1] Thialbarbital is short acting and has less of a tendency to induce respiratory depression than other barbiturate derivatives such as pentobarbital. [2] SynthesisSee also
References1. ^ Golovchinsky VB, Plehotkina SI. Difference in the sensitivity of the cerebral cortex and midbrain reticular formation to the action of diethylether and thialbarbital. Brain Research. 1971 Jul 9;30(1):37-47. {{Sedatives}}{{GABAAR PAMs}}{{sedative-stub}}2. ^ Bercovitz AB, Godke RA, Biellier HV, Short CE. Surgical anesthesia in turkeys with thialbarbital sodium. American Journal of Veterinary Research. 1975 Mar;36(3):301-2. 4 : Thiobarbiturates|GABAA receptor positive allosteric modulators|Allyl compounds|Cyclohexenes |
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