| 词条 | Thiopurine |
| 释义 |
The thiopurine drugs are purine antimetabolites widely used in the treatment of acute lymphoblastic leukemia, autoimmune disorders (e.g., Crohn's disease, rheumatoid arthritis), and organ transplant recipients. Metabolism is catalyzed by S-methyltransferase.[1] Litigation over patents covering diagnostic kits to monitor the dosing of these drugs led to a US Supreme Court case, Mayo Collaborative Services v. Prometheus Laboratories, Inc. that dramatically changed the nature of patent law in the United States.[2][3] See also
References1. ^{{Cite journal|vauthors=Sahasranaman S, Howard D, Roy S |title=Clinical pharmacology and pharmacogenetics of thiopurines |journal=Eur. J. Clin. Pharmacol. |volume=64 |issue=8 |pages=753–67 |date=August 2008 |pmid=18506437 |doi=10.1007/s00228-008-0478-6}} 2. ^Supreme Court Decision. Mayo Collaborative Services v. Prometheus Laboratories, Inc., No. 10-1150, Slip Op. at 16. [https://www.supremecourt.gov/opinions/11pdf/10-1150.pdf Decision] 3. ^Gene Quinn, Killing Industry: The Supreme Court Blows Mayo v. Prometheus {{smallcaps|IP Watchdog}} (March 20, 2012). External links
1 : Purines |
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