| 词条 | Thozalinone |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 470609358 | IUPAC_name = (RS)-2-(Dimethylamino)-5-phenyl-1,3-oxazol-4(5H)-one | image = Thozalinone.svg | alt = Skeletal formula | image2 = Thozalinone molecule spacefill.png | alt2 = Space-filling model | width2 = 155 | width = 200px | chirality = Racemic mixture | tradename = | pregnancy_category = | legal_status = Rx-only | routes_of_administration = Oral | bioavailability = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 655-05-0 | ATC_prefix = none | ATC_suffix = | PubChem = 12602 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 12082 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 68X5932947 | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D06115 | synonyms = Tozalinone, Thozalinon | C=11 | H=12 | N=2 | O=2 | molecular_weight = 204.225 g/mol | smiles = O=C2\=C(/OC2c1ccccc1)N(C)C | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C11H12N2O2/c1-13(2)11-12-10(14)9(15-11)8-6-4-3-5-7-8/h3-7,9H,1-2H3 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = JJSHYECKYLDYAR-UHFFFAOYSA-N }}Thozalinone (USAN) (brand name Stimsen; former developmental code name CL-39808) is a psychostimulant that has been used as an antidepressant in Europe.[1][2][3][4][5] It has also been trialed as an anorectic.[6] Thozalinone is described as a "dopaminergic stimulant",[7] and likely acts via inducing the release of dopamine and to a minimal extent norepinephrine; similar to analogue pemoline, it is seemingly devoid of abuse potential unlike common psychostimulants that increase catecholamines.[2][8][9] See also
References1. ^{{cite book|author=J. Elks|title=The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies|url=https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA435|date=14 November 2014|publisher=Springer|isbn=978-1-4757-2085-3|pages=435–}} {{Stimulants}}{{Antidepressants}}{{Anorectics}}{{Monoamine releasing agents}}{{nervous-system-drug-stub}}2. ^1 {{cite journal |vauthors=Greenblatt EN, Osterberg AC | title = Some pharmacologic properties of thozalinone, a new excitant | journal = Toxicology and Applied Pharmacology | volume = 7 | issue = 4 | pages = 566–78 |date=July 1965 | pmid = 4378772 | doi = 10.1016/0041-008X(65)90042-6| url = }} 3. ^{{cite book | title = Dictionary of organic compounds | publisher = Chapman & Hall | location = London | year = 1996 | pages = | isbn = 0-412-54090-8 | oclc = | doi = | url = https://books.google.com/books?id=C3Uo1co4Wv0C&lpg=PA2539&dq=thozalinone&pg=PA2539#v=onepage&q=}} 4. ^{{cite book | title = Merck index on CD-ROM: Windows | publisher = Chapman & Hall EPD | location = London | year = 1998 | pages = | isbn = 0-412-82910-X | oclc = | doi = | accessdate = }} 5. ^{{cite journal | vauthors = Gallant DM, Bishop MP, Scrignar CB, Hornsby L, Moore B, Inturrisi BB | title = A double-blind study of thozalinone (C1 39,808) in depressed outpatients | journal = Current Therapeutic Research, Clinical and Experimental | volume = 8 | issue = 12 | pages = 621–2 |date=December 1966 | pmid = 4962734 | doi = | url = }} 6. ^{{cite journal |vauthors=Leite AC, Liepen LL, Costa VP | title = [Clinical trial of Stimsem Thozalinone in the treatment of obese patients] | language = Portuguese | journal = Revista Brasileira De Medicina | volume = 28 | issue = 9 | pages = 475–8 |date=September 1971 | pmid = 5139648 | doi = | url = }} 7. ^{{cite journal|last1=Yen-koo|first1=H. C.|last2=Balazs|first2=T.|title=Detection of Dopaminergic Supersensitivity Induced by Neuroleptic Drugs in Mice|journal=Drug and Chemical Toxicology|volume=3|issue=2|year=2015|pages=237–247|issn=0148-0545|doi=10.3109/01480548009108286|pmid=6112126}} 8. ^{{cite journal |vauthors=Yen-Koo HC, Balazs T | title = Detection of dopaminergic supersensitivity induced by neuroleptic drugs in mice | journal = Drug and Chemical Toxicology | volume = 3 | issue = 2 | pages = 237–47 | year = 1980 | pmid = 6112126 | doi = 10.3109/01480548009108286 | url = http://informahealthcare.com/doi/abs/10.3109/01480548009108286}} 9. ^{{cite journal |vauthors=Yen-Koo HC, Davis DA, Balazs T | title = Inhibition of dopaminergic agonist-induced gnawing behavior by neuroleptic drugs in mice | journal = Drug and Chemical Toxicology | volume = 8 | issue = 6 | pages = 495–502 | year = 1985 | pmid = 2868876 | doi = 10.3109/01480548509041072 | url = http://informahealthcare.com/doi/abs/10.3109/01480548509041072}} 6 : Antidepressants|Amines|Lactams|Norepinephrine-dopamine releasing agents|Oxazolones|Stimulants |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。