| 词条 | Tiazofurin |
| 释义 |
| Verifiedfields = changed | verifiedrevid = 470610083 | IUPAC_name = (1R)-1-[4-(aminocarbonyl)-1,3-thiazol-2-yl]-1,4-anhydro-D-ribitol | image = Tiazofurin.svg | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 60084-10-8 | CAS_supplemental = | ATC_prefix = L01 | ATC_suffix = XX18 | ATC_supplemental = | PubChem = 457954 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 403014 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = ULJ82834RE | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 108358 | chemical_formula = | C=9 | H=12 | N=2 | O=5 | S=1 | molecular_weight = 260.268 g/mol | smiles = O=C(c1nc(sc1)[C@@H]2O[C@@H]([C@@H](O)[C@H]2O)CO)N | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C9H12N2O5S/c10-8(15)3-2-17-9(11-3)7-6(14)5(13)4(1-12)16-7/h2,4-7,12-14H,1H2,(H2,10,15)/t4-,5-,6-,7-/m1/s1 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = FVRDYQYEVDDKCR-DBRKOABJSA-N | synonyms = 2-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3-thiazole-4-carboxamide }}Tiazofurin is an inhibitor of IMP dehydrogenase. Tiazofurin and its analogues are under investigation for potential use in the treatment of cancer.[1] References1. ^{{cite journal |vauthors=Popsavin M, Torović L, Svircev M, etal |title=Synthesis and antiproliferative activity of two new tiazofurin analogues with 2'-amido functionalities |journal=Bioorg. Med. Chem. Lett. |volume=16 |issue=10 |pages=2773–6 |year=2006 |pmid=16495053 |doi=10.1016/j.bmcl.2006.02.001}} {{Intracellular chemotherapeutic agents}}{{antineoplastic-drug-stub}} 4 : Carboxamides|Ribosides|Thiazoles|Experimental cancer drugs |
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