“Tight junction protein 2”的意思、由来-开放百科全书

Tight junction proteins (TJPs) belong to a family of membrane-associated guanylate kinase (MAGUK) homologs that are involved in the organization of epithelial and endothelial intercellular junctions. TJPs bind to the cytoplasmic C termini of junctional transmembrane proteins and link them to the actin cytoskeleton [supplied by OMIM].^[2]

Interactions

Tight junction protein 2 has been shown to interact with tight junction protein 1,^[3]^[4]^[5] band 4.1^[6], occludin^[3]^[4]^[7] and USP53.^[8]

References

1. ^{{cite journal |vauthors=Duclos F, Rodius F, Wrogemann K, Mandel JL, Koenig M | title = The Friedreich ataxia region: characterization of two novel genes and reduction of the critical region to 300 kb | journal = Hum Mol Genet | volume = 3 | issue = 6 | pages = 909–914 |date=November 1994 | pmid = 7951235 | pmc = | doi =10.1093/hmg/3.6.909 }}
2. ^{{cite web | title = Entrez Gene: TJP2 tight junction protein 2 (zona occludens 2)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9414| accessdate = }}
3. ^¹{{cite journal |last=Itoh |first=M |authorlink= |author2=Morita K |author3=Tsukita S |date=February 1999 |title=Characterization of ZO-2 as a MAGUK family member associated with tight as well as adherens junctions with a binding affinity to occludin and alpha catenin |journal=J. Biol. Chem. |volume=274 |issue=9 |pages=5981–5986 | issn = 0021-9258| pmid = 10026224 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.274.9.5981 }}
4. ^¹{{cite journal |last=Wittchen |first=E S |authorlink= |author2=Haskins J |author3=Stevenson B R |date=December 1999 |title=Protein interactions at the tight junction. Actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3 |journal=J. Biol. Chem. |volume=274 |issue=49 |pages=35179–35185 | issn = 0021-9258| pmid = 10575001 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.274.49.35179 }}
5. ^{{cite journal |last=Fanning |first=A S |authorlink= |author2=Jameson B J |author3=Jesaitis L A |author4=Anderson J M |date=November 1998 |title=The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton |journal=J. Biol. Chem. |volume=273 |issue=45 |pages=29745–29753 | issn = 0021-9258| pmid = 9792688 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.273.45.29745 }}
6. ^{{cite journal |last=Mattagajasingh |first=S N |authorlink= |author2=Huang S C |author3=Hartenstein J S |author4=Benz E J |date=September 2000 |title=Characterization of the interaction between protein 4.1R and ZO-2. A possible link between the tight junction and the actin cytoskeleton |journal=J. Biol. Chem. |volume=275 |issue=39 |pages=30573–30585 | issn = 0021-9258| pmid = 10874042 |doi = 10.1074/jbc.M004578200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}
7. ^{{cite journal |last=Peng |first=Bi-Hung |authorlink= |author2=Lee J Ching |author3=Campbell Gerald A |date=December 2003 |title=In vitro protein complex formation with cytoskeleton-anchoring domain of occludin identified by limited proteolysis |journal=J. Biol. Chem. |volume=278 |issue=49 |pages=49644–49651 | issn = 0021-9258| pmid = 14512431 |doi = 10.1074/jbc.M302782200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}
8. ^{{cite journal | vauthors = Kazmierczak M, Harris SL, Kazmierczak P, Shah P, Starovoytov V, Ohlemiller KK, Schwander M | title = Progressive Hearing Loss in Mice Carrying a Mutation in Usp53 | journal = The Journal of Neuroscience | volume = 35 | issue = 47 | pages = 15582–98 | date = November 2015 | pmid = 26609154 | pmc = 4659823 | doi = 10.1523/JNEUROSCI.1965-15.2015 }}

Further reading

{{cite journal |vauthors=Denker BM, Nigam SK |title=Molecular structure and assembly of the tight junction |journal=Am. J. Physiol. |volume=274 |issue= 1 Pt 2 |pages= F1–9 |year= 1998 |pmid= 9458817 |doi= }}

{{cite journal |vauthors=González-Mariscal L, Betanzos A, Avila-Flores A |title=MAGUK proteins: structure and role in the tight junction |journal=Semin. Cell Dev. Biol. |volume=11 |issue= 4 |pages= 315–324 |year= 2000 |pmid= 10966866 |doi= 10.1006/scdb.2000.0178 }}

{{cite journal |vauthors=King JE, Eugenin EA, Buckner CM, Berman JW |title=HIV tat and neurotoxicity |journal=Microbes Infect. |volume=8 |issue= 5 |pages= 1347–1357 |year= 2006 |pmid= 16697675 |doi= 10.1016/j.micinf.2005.11.014 }}

{{cite journal |vauthors=Van Itallie CM, Balda MS, Anderson JM |title=Epidermal growth factor induces tyrosine phosphorylation and reorganization of the tight junction protein ZO-1 in A431 cells |journal=J. Cell Sci. |volume=108 |issue= 4|pages= 1735–42 |year= 1995 |pmid= 7542259 |doi= }}

{{cite journal | author=Beatch M |title=The tight junction protein ZO-2 contains three PDZ (PSD-95/Discs-Large/ZO-1) domains and an alternatively spliced region |journal=J. Biol. Chem. |volume=271 |issue= 42 |pages= 25723–25726 |year= 1996 |pmid= 8824195 |doi=10.1074/jbc.271.42.25723 |name-list-format=vanc| author2=Jesaitis LA | author3=Gallin WJ | display-authors=3 | last4=Goodenough | first4=DA | last5=Stevenson | first5=BR }}

{{cite journal |vauthors=Itoh M, Morita K, Tsukita S |title=Characterization of ZO-2 as a MAGUK family member associated with tight as well as adherens junctions with a binding affinity to occludin and alpha catenin |journal=J. Biol. Chem. |volume=274 |issue= 9 |pages= 5981–5986 |year= 1999 |pmid= 10026224 |doi=10.1074/jbc.274.9.5981 }}

{{cite journal | author=Chlenski A |title=Tight junction protein ZO-2 is differentially expressed in normal pancreatic ducts compared to human pancreatic adenocarcinoma |journal=Int. J. Cancer |volume=82 |issue= 1 |pages= 137–144 |year= 1999 |pmid= 10360833 |doi=10.1002/(SICI)1097-0215(19990702)82:1<137::AID-IJC23>3.0.CO;2-F |name-list-format=vanc| author2=Ketels KV | author3=Tsao MS | display-authors=3 | last4=Talamonti | first4=Mark S. | last5=Anderson | first5=Marla R. | last6=Oyasu | first6=Ryoichi | last7=Scarpelli | first7=Dante G. }}

{{cite journal | author=Chlenski A |title=zo-2 gene alternative promoters in normal and neoplastic human pancreatic duct cells |journal=Int. J. Cancer |volume=83 |issue= 3 |pages= 349–358 |year= 1999 |pmid= 10495427 |doi=10.1002/(SICI)1097-0215(19991029)83:3<349::AID-IJC10>3.0.CO;2-C |name-list-format=vanc| author2=Ketels KV | author3=Engeriser JL | display-authors=3 | last4=Talamonti | first4=Mark S. | last5=Tsao | first5=Ming-Sound | last6=Koutnikova | first6=Hanna | last7=Oyasu | first7=Ryoichi | last8=Scarpelli | first8=Dante G. }}

{{cite journal |vauthors=Wittchen ES, Haskins J, Stevenson BR |title=Protein interactions at the tight junction. Actin has multiple binding partners, and ZO-1 forms independent complexes with ZO-2 and ZO-3 |journal=J. Biol. Chem. |volume=274 |issue= 49 |pages= 35179–35185 |year= 2000 |pmid= 10575001 |doi=10.1074/jbc.274.49.35179 }}

{{cite journal | author=Itoh M |title=Direct binding of three tight junction-associated MAGUKs, ZO-1, ZO-2, and ZO-3, with the COOH termini of claudins |journal=J. Cell Biol. |volume=147 |issue= 6 |pages= 1351–1363 |year= 2000 |pmid= 10601346 |doi=10.1083/jcb.147.6.1351 | pmc=2168087 |name-list-format=vanc| author2=Furuse M | author3=Morita K | display-authors=3 | last4=Kubota | first4=K | last5=Saitou | first5=M | last6=Tsukita | first6=S }}

{{cite journal | author=Cordenonsi M |title=Cingulin contains globular and coiled-coil domains and interacts with ZO-1, ZO-2, ZO-3, and myosin |journal=J. Cell Biol. |volume=147 |issue= 7 |pages= 1569–1582 |year= 2000 |pmid= 10613913 |doi=10.1083/jcb.147.7.1569 | pmc=2174252 |name-list-format=vanc| author2=D'Atri F | author3=Hammar E | display-authors=3 | last4=Parry | first4=DA | last5=Kendrick-Jones | first5=J | last6=Shore | first6=D | last7=Citi | first7=S }}

{{cite journal |vauthors=Mattagajasingh SN, Huang SC, Hartenstein JS, Benz EJ |title=Characterization of the interaction between protein 4.1R and ZO-2. A possible link between the tight junction and the actin cytoskeleton |journal=J. Biol. Chem. |volume=275 |issue= 39 |pages= 30573–30585 |year= 2000 |pmid= 10874042 |doi= 10.1074/jbc.M004578200 }}

{{cite journal | author=Chlenski A |title=Organization and expression of the human zo-2 gene (tjp-2) in normal and neoplastic tissues |journal=Biochim. Biophys. Acta |volume=1493 |issue= 3 |pages= 319–24 |year= 2000 |pmid= 11018256 |doi= 10.1016/S0167-4781(00)00185-8|name-list-format=vanc| author2=Ketels KV | author3=Korovaitseva GI | display-authors=3 | last4=Talamonti | first4=MS | last5=Oyasu | first5=R | last6=Scarpelli | first6=DG }}

{{cite journal |vauthors=Citi S, D'Atri F, Parry DA |title=Human and Xenopus cingulin share a modular organization of the coiled-coil rod domain: predictions for intra- and intermolecular assembly |journal=J. Struct. Biol. |volume=131 |issue= 2 |pages= 135–145 |year= 2000 |pmid= 11042084 |doi= 10.1006/jsbi.2000.4284 }}

{{cite journal |vauthors=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–1795 |year= 2001 |pmid= 11076863 |doi=10.1101/gr.143000 | pmc=310948 }}

{{cite journal |vauthors=Glaunsinger BA, Weiss RS, Lee SS, Javier R |title=Link of the unique oncogenic properties of adenovirus type 9 E4-ORF1 to a select interaction with the candidate tumor suppressor protein ZO-2 |journal=EMBO J. |volume=20 |issue= 20 |pages= 5578–5586 |year= 2001 |pmid= 11598001 |doi= 10.1093/emboj/20.20.5578 | pmc=125668 }}

{{cite journal |vauthors=Islas S, Vega J, Ponce L, González-Mariscal L |title=Nuclear localization of the tight junction protein ZO-2 in epithelial cells |journal=Exp. Cell Res. |volume=274 |issue= 1 |pages= 138–148 |year= 2002 |pmid= 11855865 |doi= 10.1006/excr.2001.5457 }}