| 词条 | Tioconazole |
| 释义 |
| Verifiedfields = changed | verifiedrevid = 415485693 | IUPAC_name = (RS)-1-[2-[(2-Chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole | image = Tioconazole.svg | chirality = Racemic mixture | tradename = Vagistat-1 | Drugs.com = {{drugs.com|monograph|tioconazole}} | pregnancy_category = | legal_US= OTC | routes_of_administration = Topical | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 65899-73-2 | ATC_prefix = D01 | ATC_suffix = AC07 | ATC_supplemental = {{ATC|G01|AF08}} | PubChem = 5482 | DrugBank_Ref = {{drugbankcite|changed|drugbank}} | DrugBank = DB01007 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 5282 | UNII_Ref = {{fdacite|changed|FDA}} | UNII = S57Y5X1117 | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D00890 | ChEBI_Ref = {{ebicite|changed|EBI}} | ChEBI = 9604 | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 1200438 | C=16 | H=13 | Cl=3 | N=2 | O=1 | S=1 | molecular_weight = 387.711 g/mol | synonyms = Thioconazole }} Tioconazole is an antifungal medication of the imidazole class used to treat infections caused by a fungus or yeast. It is marketed under the brand names Trosyd and Gyno-Trosyd (Pfizer, now Johnson & Johnson). Tioconazole ointments serve to treat women's vaginal yeast infections.[1] They are available in one day doses, as opposed to the 7-day treatments more common in use in the past. Tioconazole topical (skin) preparations are also available for ringworm, jock itch, athlete's foot, and tinea versicolor or "sun fungus". It was patented in 1975 and approved for medical use in 1982.[2] Side effectsSide effects (for the women's formulas) may include temporary burning/irritation of the vaginal area, moderate drowsiness, headache similar to a sinus headache, hives, and upper respiratory infection.{{Citation needed|date=April 2010}} These side effects may be only temporary, and do not normally interfere with the patient's comfort enough to outweigh the end result. SynthesisAntimycotic imidazole derivative. A displacement reaction between 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethanol and 2-chloro-3-(chloromethyl)thiophene is performed. References1. ^Tioconazole, Mayo Clinic {{Commons category}}{{Antifungals}}{{Gynecological anti-infectives and antiseptics}}2. ^{{cite book |last1=Fischer |first1=Jnos |last2=Ganellin |first2=C. Robin |title=Analogue-based Drug Discovery |date=2006 |publisher=John Wiley & Sons |isbn=9783527607495 |page=503 |url=https://books.google.ca/books?id=FjKfqkaKkAAC&pg=PA503 |language=en}} 3. ^G. E. Gymer, {{Cite patent|BE|841309}}; idem, {{US patent|4062966}} (1976, 1977 both to Pfizer). 8 : 21-Hydroxylase inhibitors|Aromatase inhibitors|Chloroarenes|CYP17A1 inhibitors|Ethers|Imidazole antifungals|Lanosterol 14α-demethylase inhibitors|Thiophenes |
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