| 词条 | Tiratricol |
| 释义 |
| Verifiedfields = changed | verifiedrevid = 470610738 | IUPAC_name = [4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]acetic acid | image = Tiratricol.svg | width = 240 | image2 = Tiratricol 3D ball.png | alt2 = Ball-and-stick model of the tiratricol molecule | tradename = | Drugs.com = {{drugs.com|international|tiratricol}} | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = Presumed high | metabolism = Hepatic glucuronidation | elimination_half-life = | excretion = Biliary | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 51-24-1 | ATC_prefix = H03 | ATC_suffix = AA04 | ATC_supplemental = {{ATC|D11|AX08}} | PubChem = 5803 | IUPHAR_ligand = 2637 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = DB03604 | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 5598 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 29OQ9EU4R1 | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D07214 | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 41632 | C=14 | H=9 | I=3 | O=4 | molecular_weight = 621.932 g/mol | smiles = Ic2cc(Oc1c(I)cc(cc1I)CC(=O)O)ccc2O | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C14H9I3O4/c15-9-6-8(1-2-12(9)18)21-14-10(16)3-7(4-11(14)17)5-13(19)20/h1-4,6,18H,5H2,(H,19,20) | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = UOWZUVNAGUAEQC-UHFFFAOYSA-N | synonyms = 3,3',5-triiodothyroacetic acid TRIAC }} Tiratricol (also known as TRIAC or triiodothyroacetic acid) is a thyroid hormone analogue. Triiodothyroacetic acid is also a physiologic thyroid hormone that is present in the normal organism in low concentrations. UsesIt is indicated in the management of thyroid hormone resistance syndrome[1] and is used, in combination with levothyroxine, to suppress thyroid-stimulating hormone production in patients with thyroid cancer. It has been investigated for use in reducing goiter.[2] It has also shown some effectiveness in reducing the atrophy caused when using corticosteroids.[3] Tiratricol has also been widely marketed, under various trade names, as a weight loss aid. In 1999 and 2000, the United States Food and Drug Administration and Health Canada both issued warnings to the public regarding the use of dietary supplements containing tiratricol.[4][5] Legal statusTiratricol is not approved for sale in Canada or the United States. It was once an approved drug in Brazil, but its marketing authorization was suspended in 2003, effectively prohibiting its sale.[6] Tiratricol is still available in France for therapy of thyroid hormone resistance and adjuvant therapy of thyroid cancer.[7] It is available as an orphan drug to be prescribed by registered specialists in Europe. References1. ^{{cite journal |vauthors=Carvalho GA, Ramos HE |title=[Thyroid hormone resistance syndrome] |language=Portuguese |journal=Arq Bras Endocrinol Metabol |volume=48 |issue=1 |pages=83–92 |year=2004 |pmid=15611821 |doi=10.1590/S0004-27302004000100010}} {{cite web|url= http://www.scielo.br/pdf/abem/v48n1/19522.pdf |title=Free full text }} {{small|(95.3 KiB)}} {{Other dermatological preparations}}{{Thyroid therapy}}{{Thyroid hormone receptor modulators}}{{Thyroid hormone intermediates}}{{systemic-hormonal-drug-stub}}{{dermatologic-drug-stub}}2. ^{{cite journal |vauthors=Brenta G, Schnitman M, Fretes O, etal |title=Comparative efficacy and side effects of the treatment of euthyroid goiter with levo-thyroxine or triiodothyroacetic acid |journal=J. Clin. Endocrinol. Metab. |volume=88 |issue=11 |pages=5287–92 |date=November 2003 |pmid=14602763 |doi= 10.1210/jc.2003-030095|url=http://jcem.endojournals.org/cgi/pmidlookup?view=long&pmid=14602763}} 3. ^{{cite journal |vauthors=Yazdanparast P, Carlsson B, Oikarinen A, Risteli J, Lavin T, Faergemann J |title=Action of topical thyroid hormone analogue, triiodothyroacetic acid in reversing glucocorticoid-induced skin atrophy in humans |journal=Thyroid |volume=16 |issue=11 |pages=1157–62 |date=November 2006 |pmid=17123343 |doi=10.1089/thy.2006.16.1157}} 4. ^{{cite press release | url = http://www.fda.gov/bbs/topics/ANSWERS/ANS01057.html | title = FDA Warns Against Consuming Dietary Supplements Containing Tiratricol | date = November 21, 2000 | accessdate = 2007-08-08 | publisher = U.S. Food and Drug Administration}} 5. ^{{cite press release | url = http://www.hc-sc.gc.ca/ahc-asc/media/advisories-avis/1999/1999_143_e.html | title = Health Canada issues warning on products containing Tiratricol (TRIAC) | date = December 2, 1999 | accessdate = 2007-08-08 | publisher = Health Canada}} 6. ^{{cite web | url = http://www.endocrino.org.br/noticia_g_exibe.php?id=9 | title = Anvisa suspende Tiratricol | language = Portuguese | date = | accessdate = 2007-08-08 | publisher = Brazilian Society of Endocrinology and Metabolism |archiveurl = https://web.archive.org/web/20071009062707/http://www.endocrino.org.br/noticia_g_exibe.php?id=9 |archivedate = 2007-10-09}} 7. ^Laboratoires DB PHARMA: Teatrois information 5 : Orphan drugs|Iodoarenes|Phenols|Phenol ethers|Thyroid hormone receptor agonists |
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