| 词条 | Tissue inhibitor of metalloproteinase |
| 释义 |
The matrix metalloproteinases are inhibited by specific endogenous tissue inhibitors of metalloproteinases (TIMPs), which comprise a family of four protease inhibitors: TIMP1, TIMP2, TIMP3 and TIMP4.[1] Overall, all MMPs are inhibited by TIMPs once they are activated but the gelatinases (MMP-2 and MMP-9) can form complexes with TIMPs when the enzymes are in the latent form. The complex of latent MMP-2 (pro-MMP-2)with TIMP-2 serves to facilitate the activation of pro-MMP-2 at the cell surface by MT1-MMP (MMP-14), a membrane-anchored MMP. The role of the pro-MMP-9/TIMP-1 complex is still unknown. References1. ^{{Cite journal|vauthors=Brew K, Dinakarpandian D, Nagase H |title=Tissue inhibitors of metalloproteinases: evolution, structure and function |journal=Biochim Biophys Acta |volume=1477 |issue=1–2 |pages=267–83 |year=2000 |pmid=10708863|doi=10.1016/S0167-4838(99)00279-4}}
External links
1 : Human proteins |
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