“TPH2”的意思、由来-开放百科全书

Function

Tryptophan hydroxylase (TPH; EC 1.14.16.4) is the rate-limiting enzyme in the synthesis of serotonin (5-hydroxytryptamine, or 5HT). 5HT is causally involved in numerous central nervous activities, and it has several functions in peripheral tissues, including the maintenance of vascular tone and gut motility.[supplied by OMIM]^[3]

References

1. ^{{cite journal | vauthors = Walther DJ, Peter JU, Bashammakh S, Hörtnagl H, Voits M, Fink H, Bader M | title = Synthesis of serotonin by a second tryptophan hydroxylase isoform | journal = Science | volume = 299 | issue = 5603 | pages = 76 | date = Jan 2003 | pmid = 12511643 | doi = 10.1126/science.1078197 }}
2. ^{{cite journal | vauthors = Zill P, Büttner A, Eisenmenger W, Möller HJ, Ackenheil M, Bondy B | title = Analysis of tryptophan hydroxylase I and II mRNA expression in the human brain: a post-mortem study | journal = Journal of Psychiatric Research | volume = 41 | issue = 1-2 | pages = 168–73 | year = 2005 | pmid = 16023677 | doi = 10.1016/j.jpsychires.2005.05.004 }}
3. ^{{cite web | title = Entrez Gene: TPH2 tryptophan hydroxylase 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=121278| accessdate = }}

Further reading

{{cite journal | vauthors = Walther DJ, Peter JU, Bashammakh S, Hörtnagl H, Voits M, Fink H, Bader M | title = Synthesis of serotonin by a second tryptophan hydroxylase isoform | journal = Science | volume = 299 | issue = 5603 | pages = 76 | date = Jan 2003 | pmid = 12511643 | doi = 10.1126/science.1078197 }}

{{cite journal | vauthors = Walther DJ, Bader M | title = A unique central tryptophan hydroxylase isoform | journal = Biochemical Pharmacology | volume = 66 | issue = 9 | pages = 1673–80 | date = Nov 2003 | pmid = 14563478 | doi = 10.1016/S0006-2952(03)00556-2 }}

{{cite journal | vauthors = Zill P, Baghai TC, Zwanzger P, Schüle C, Eser D, Rupprecht R, Möller HJ, Bondy B, Ackenheil M | title = SNP and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene provide evidence for association with major depression | journal = Molecular Psychiatry | volume = 9 | issue = 11 | pages = 1030–6 | date = Nov 2004 | pmid = 15124006 | doi = 10.1038/sj.mp.4001525 }}

{{cite journal | vauthors = Breidenthal SE, White DJ, Glatt CE | title = Identification of genetic variants in the neuronal form of tryptophan hydroxylase (TPH2) | journal = Psychiatric Genetics | volume = 14 | issue = 2 | pages = 69–72 | date = Jun 2004 | pmid = 15167691 | doi = 10.1097/01.ypg.0000107929.32051.58 }}

{{cite journal | vauthors = De Luca V, Mueller DJ, Tharmalingam S, King N, Kennedy JL | title = Analysis of the novel TPH2 gene in bipolar disorder and suicidality | journal = Molecular Psychiatry | volume = 9 | issue = 10 | pages = 896–7 | date = Oct 2004 | pmid = 15197398 | doi = 10.1038/sj.mp.4001531 }}

{{cite journal | vauthors = Harvey M, Shink E, Tremblay M, Gagné B, Raymond C, Labbé M, Walther DJ, Bader M, Barden N | title = Support for the involvement of TPH2 gene in affective disorders | journal = Molecular Psychiatry | volume = 9 | issue = 11 | pages = 980–1 | date = Nov 2004 | pmid = 15263906 | doi = 10.1038/sj.mp.4001557 }}

{{cite journal | vauthors = Zill P, Büttner A, Eisenmenger W, Möller HJ, Bondy B, Ackenheil M | title = Single nucleotide polymorphism and haplotype analysis of a novel tryptophan hydroxylase isoform (TPH2) gene in suicide victims | journal = Biological Psychiatry | volume = 56 | issue = 8 | pages = 581–6 | date = Oct 2004 | pmid = 15476687 | doi = 10.1016/j.biopsych.2004.07.015 }}

{{cite journal | vauthors = Zhang X, Gainetdinov RR, Beaulieu JM, Sotnikova TD, Burch LH, Williams RB, Schwartz DA, Krishnan KR, Caron MG | title = Loss-of-function mutation in tryptophan hydroxylase-2 identified in unipolar major depression | journal = Neuron | volume = 45 | issue = 1 | pages = 11–6 | date = Jan 2005 | pmid = 15629698 | doi = 10.1016/j.neuron.2004.12.014 }}

{{cite journal | vauthors = Coon H, Dunn D, Lainhart J, Miller J, Hamil C, Battaglia A, Tancredi R, Leppert MF, Weiss R, McMahon W | title = Possible association between autism and variants in the brain-expressed tryptophan hydroxylase gene (TPH2) | journal = American Journal of Medical Genetics Part B | volume = 135B | issue = 1 | pages = 42–6 | date = May 2005 | pmid = 15768392 | doi = 10.1002/ajmg.b.30168 }}

{{cite journal | vauthors = Sheehan K, Lowe N, Kirley A, Mullins C, Fitzgerald M, Gill M, Hawi Z | title = Tryptophan hydroxylase 2 (TPH2) gene variants associated with ADHD | journal = Molecular Psychiatry | volume = 10 | issue = 10 | pages = 944–9 | date = Oct 2005 | pmid = 15940290 | doi = 10.1038/sj.mp.4001698 }}

{{cite journal | vauthors = Shamir A, Shaltiel G, Levi I, Belmaker RH, Agam G | title = Postmortem parietal cortex TPH2 expression is not altered in schizophrenic, unipolar-depressed, and bipolar patients vs control subjects | journal = Journal of Molecular Neuroscience | volume = 26 | issue = 1 | pages = 33–7 | year = 2005 | pmid = 15968084 | doi = 10.1385/JMN:26:1:033 }}

{{cite journal | vauthors = Brown SM, Peet E, Manuck SB, Williamson DE, Dahl RE, Ferrell RE, Hariri AR | title = A regulatory variant of the human tryptophan hydroxylase-2 gene biases amygdala reactivity | journal = Molecular Psychiatry | volume = 10 | issue = 9 | pages = 884–8, 805 | date = Sep 2005 | pmid = 16044172 | doi = 10.1038/sj.mp.4001716 }}

{{cite journal | vauthors = Walitza S, Renner TJ, Dempfle A, Konrad K, Wewetzer CH, Halbach A, Herpertz-Dahlmann B, Remschmidt H, Smidt J, Linder M, Flierl L, Knölker U, Friedel S, Schäfer H, Gross C, Hebebrand J, Warnke A, Lesch KP | title = Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder | journal = Molecular Psychiatry | volume = 10 | issue = 12 | pages = 1126–32 | date = Dec 2005 | pmid = 16116490 | doi = 10.1038/sj.mp.4001734 }}

{{cite journal | vauthors = Canli T, Congdon E, Gutknecht L, Constable RT, Lesch KP | title = Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation | journal = Journal of Neural Transmission | volume = 112 | issue = 11 | pages = 1479–85 | date = Nov 2005 | pmid = 16245070 | doi = 10.1007/s00702-005-0391-4 }}

{{cite journal | vauthors = Mössner R, Freitag CM, Gutknecht L, Reif A, Tauber R, Franke P, Fritze J, Wagner G, Peikert G, Wenda B, Sand P, Rietschel M, Garritsen H, Jacob C, Lesch KP, Deckert J | title = The novel brain-specific tryptophan hydroxylase-2 gene in panic disorder | journal = Journal of Psychopharmacology | volume = 20 | issue = 4 | pages = 547–52 | date = Jul 2006 | pmid = 16401665 | doi = 10.1177/0269881106059704 }}

{{cite journal | vauthors = De Luca V, Hlousek D, Likhodi O, Van Tol HH, Kennedy JL, Wong AH | title = The interaction between TPH2 promoter haplotypes and clinical-demographic risk factors in suicide victims with major psychoses | journal = Genes, Brain, and Behavior | volume = 5 | issue = 1 | pages = 107–10 | date = Feb 2006 | pmid = 16436194 | doi = 10.1111/j.1601-183X.2005.00182.x }}

{{cite journal | vauthors = Delorme R, Durand CM, Betancur C, Wagner M, Ruhrmann S, Grabe HJ, Nygren G, Gillberg C, Leboyer M, Bourgeron T, Courtet P, Jollant F, Buresi C, Aubry JM, Baud P, Bondolfi G, Bertschy G, Perroud N, Malafosse A | title = No human tryptophan hydroxylase-2 gene R441H mutation in a large cohort of psychiatric patients and control subjects | journal = Biological Psychiatry | volume = 60 | issue = 2 | pages = 202–3 | date = Jul 2006 | pmid = 16581035 | doi = 10.1016/j.biopsych.2005.12.014 | url = http://www.hal.inserm.fr/inserm-00124742/document }}

{{cite journal | vauthors = Carkaci-Salli N, Flanagan JM, Martz MK, Salli U, Walther DJ, Bader M, Vrana KE|authorlink7=Kent Vrana | title = Functional domains of human tryptophan hydroxylase 2 (hTPH2) | journal = The Journal of Biological Chemistry | volume = 281 | issue = 38 | pages = 28105–12 | date = Sep 2006 | pmid = 16864580 | doi = 10.1074/jbc.M602817200 }}

1 : Biology of bipolar disorder

Function

See also

References

Further reading