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词条 TRAF2
释义

  1. Function

  2. Interactions

  3. Model organisms

  4. References

  5. Further reading

{{Infobox_gene}}TNF receptor-associated factor 2 is a protein that in humans is encoded by the TRAF2 gene.[1]

Function

The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms complexes with other TRAF proteins. TRAF2 is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-κB. The protein complex formed by TRAF2 and TRAF1 interacts with the IAP family members cIAP1 and cIAP2, and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. cIAP1 can ubiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined.[2]

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Interactions

TRAF2 has been shown to interact with:

{{div col|colwidth=20em}}
  • ASK1,[3][4][5]
  • BCL10,[6]
  • BIRC2,[6][8][9][10][11][7]
  • Baculoviral IAP repeat-containing protein 3,[6][8][9][10]
  • CASP8AP2,[11]
  • CD134,[18]
  • CD137,[12][13]
  • CD27,[14][15]
  • CD40,[16][17][18]
  • CFLAR,[19][20]
  • CHUK,[28][29][21]
  • Caveolin 1,[22][23]
  • EDARADD,[24]
  • HIVEP3,[25]
  • IKK2,[26][27]
  • Low affinity nerve growth factor receptor,[28]
  • MAP3K14,[18][29]
  • MAP3K1[30]
  • MAP3K7IP2,[27][31]
  • MAP4K2,[32]
  • MAP4K5,[33]
  • RANK,[34][35][36][37]
  • RIPK1,[18][50][51][38]
  • SPHK1,[39]
  • TANK,[54][55][40][41]
  • TANK-binding kinase 1,[42][43]
  • TNFAIP3,[44]
  • TNFRSF13B,[45]
  • TNFRSF14,[62][46]
  • TNFRSF1A,[47][48][49]
  • TNFRSF1B,[1][50][42][50][51][52][53]
  • TNFSF14,[54]
  • TRADD,[18][50][38][42][49][55][56]
  • TRAF interacting protein,[57]
  • TRAF1,[58][42] and
  • UBE2N.[59]
{{Div col end}}{{Clear}}

Model organisms

Model organisms have been used in the study of TRAF2 function. A conditional knockout mouse line called Traf2tm1a(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute.[60] Male and female animals underwent a standardized phenotypic screen[61] to determine the effects of deletion.[62][63][64][65] Additional screens performed: - In-depth immunological phenotyping[66]{{clear}}

References

1. ^1 {{cite journal | vauthors = Song HY, Donner DB | title = Association of a RING finger protein with the cytoplasmic domain of the human type-2 tumour necrosis factor receptor | journal = Biochem J | volume = 309 | issue = Pt 3 | pages = 825–9 | date = September 1995 | pmid = 7639698 | pmc = 1135706 | doi = }}
2. ^{{cite web | title = Entrez Gene: TRAF2 TNF receptor-associated factor 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7186| accessdate = }}
3. ^{{cite journal | vauthors = Nishitoh H, Saitoh M, Mochida Y, Takeda K, Nakano H, Rothe M, Miyazono K, Ichijo H | title = ASK1 is essential for JNK/SAPK activation by TRAF2 | journal = Mol. Cell | volume = 2 | issue = 3 | pages = 389–95 | date = September 1998 | pmid = 9774977 | doi = 10.1016/s1097-2765(00)80283-x}}
4. ^{{cite journal | vauthors = Hoeflich KP, Yeh WC, Yao Z, Mak TW, Woodgett JR | title = Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1) | journal = Oncogene | volume = 18 | issue = 42 | pages = 5814–20 | date = October 1999 | pmid = 10523862 | doi = 10.1038/sj.onc.1202975 }}
5. ^{{cite journal | vauthors = Gan B, Peng X, Nagy T, Alcaraz A, Gu H, Guan JL | title = Role of FIP200 in cardiac and liver development and its regulation of TNFalpha and TSC-mTOR signaling pathways | journal = J. Cell Biol. | volume = 175 | issue = 1 | pages = 121–33 | date = October 2006 | pmid = 17015619 | pmc = 2064504 | doi = 10.1083/jcb.200604129 }}
6. ^1 2 {{cite journal | vauthors = Yoneda T, Imaizumi K, Maeda M, Yui D, Manabe T, Katayama T, Sato N, Gomi F, Morihara T, Mori Y, Miyoshi K, Hitomi J, Ugawa S, Yamada S, Okabe M, Tohyama M | title = Regulatory mechanisms of TRAF2-mediated signal transduction by Bcl10, a MALT lymphoma-associated protein | journal = J. Biol. Chem. | volume = 275 | issue = 15 | pages = 11114–20 | date = April 2000 | pmid = 10753917 | doi = 10.1074/jbc.275.15.11114}}
7. ^{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}
8. ^1 {{cite journal | vauthors = Uren AG, Pakusch M, Hawkins CJ, Puls KL, Vaux DL | title = Cloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factors | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 10 | pages = 4974–8 | date = May 1996 | pmid = 8643514 | pmc = 39390 | doi = 10.1073/pnas.93.10.4974}}
9. ^1 {{cite journal | vauthors = Roy N, Deveraux QL, Takahashi R, Salvesen GS, Reed JC | title = The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases | journal = EMBO J. | volume = 16 | issue = 23 | pages = 6914–25 | date = Dec 1997 | pmid = 9384571 | pmc = 1170295 | doi = 10.1093/emboj/16.23.6914 }}
10. ^1 {{cite journal | vauthors = Li X, Yang Y, Ashwell JD | title = TNF-RII and c-IAP1 mediate ubiquitination and degradation of TRAF2 | journal = Nature | volume = 416 | issue = 6878 | pages = 345–7 | date = March 2002 | pmid = 11907583 | doi = 10.1038/416345a }}
11. ^{{cite journal | vauthors = Choi YH, Kim KB, Kim HH, Hong GS, Kwon YK, Chung CW, Park YM, Shen ZJ, Kim BJ, Lee SY, Jung YK | title = FLASH coordinates NF-kappa B activity via TRAF2 | journal = J. Biol. Chem. | volume = 276 | issue = 27 | pages = 25073–7 | date = July 2001 | pmid = 11340079 | doi = 10.1074/jbc.M102941200 }}
12. ^1 {{cite journal | vauthors = Arch RH, Thompson CB | title = 4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB | journal = Mol. Cell. Biol. | volume = 18 | issue = 1 | pages = 558–65 | date = January 1998 | pmid = 9418902 | pmc = 121523 | doi = }}
13. ^{{cite journal | vauthors = Jang IK, Lee ZH, Kim YJ, Kim SH, Kwon BS | title = Human 4-1BB (CD137) signals are mediated by TRAF2 and activate nuclear factor-kappa B | journal = Biochem. Biophys. Res. Commun. | volume = 242 | issue = 3 | pages = 613–20 | date = January 1998 | pmid = 9464265 | doi = 10.1006/bbrc.1997.8016 }}
14. ^{{cite journal | vauthors = Yamamoto H, Kishimoto T, Minamoto S | title = NF-kappaB activation in CD27 signaling: involvement of TNF receptor-associated factors in its signaling and identification of functional region of CD27 | journal = J. Immunol. | volume = 161 | issue = 9 | pages = 4753–9 | date = November 1998 | pmid = 9794406 | doi = }}
15. ^{{cite journal | vauthors = Akiba H, Nakano H, Nishinaka S, Shindo M, Kobata T, Atsuta M, Morimoto C, Ware CF, Malinin NL, Wallach D, Yagita H, Okumura K | title = CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase | journal = J. Biol. Chem. | volume = 273 | issue = 21 | pages = 13353–8 | date = May 1998 | pmid = 9582383 | doi = 10.1074/jbc.273.21.13353}}
16. ^{{cite journal | vauthors = McWhirter SM, Pullen SS, Holton JM, Crute JJ, Kehry MR, Alber T | title = Crystallographic analysis of CD40 recognition and signaling by human TRAF2 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 15 | pages = 8408–13 | date = July 1999 | pmid = 10411888 | pmc = 17529 | doi = 10.1073/pnas.96.15.8408}}
17. ^{{cite journal | vauthors = Tsukamoto N, Kobayashi N, Azuma S, Yamamoto T, Inoue J | title = Two differently regulated nuclear factor kappaB activation pathways triggered by the cytoplasmic tail of CD40 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 4 | pages = 1234–9 | date = February 1999 | pmid = 9990007 | pmc = 15446 | doi = 10.1073/pnas.96.4.1234}}
18. ^1 2 3 {{cite journal | vauthors = Malinin NL, Boldin MP, Kovalenko AV, Wallach D | title = MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1 | journal = Nature | volume = 385 | issue = 6616 | pages = 540–4 | date = February 1997 | pmid = 9020361 | doi = 10.1038/385540a0 }}
19. ^{{cite journal | vauthors = Shu HB, Halpin DR, Goeddel DV | title = Casper is a FADD- and caspase-related inducer of apoptosis | journal = Immunity | volume = 6 | issue = 6 | pages = 751–63 | date = June 1997 | pmid = 9208847 | doi = 10.1016/S1074-7613(00)80450-1}}
20. ^{{cite journal | vauthors = Kataoka T, Budd RC, Holler N, Thome M, Martinon F, Irmler M, Burns K, Hahne M, Kennedy N, Kovacsovics M, Tschopp J | title = The caspase-8 inhibitor FLIP promotes activation of NF-kappaB and Erk signaling pathways | journal = Curr. Biol. | volume = 10 | issue = 11 | pages = 640–8 | date = June 2000 | pmid = 10837247 | doi = 10.1016/s0960-9822(00)00512-1}}
21. ^{{cite journal | vauthors = Régnier CH, Song HY, Gao X, Goeddel DV, Cao Z, Rothe M | title = Identification and characterization of an IkappaB kinase | journal = Cell | volume = 90 | issue = 2 | pages = 373–83 | date = July 1997 | pmid = 9244310 | doi = 10.1016/S0092-8674(00)80344-X}}
22. ^{{cite journal | vauthors = Feng X, Gaeta ML, Madge LA, Yang JH, Bradley JR, Pober JS | title = Caveolin-1 associates with TRAF2 to form a complex that is recruited to tumor necrosis factor receptors | journal = J. Biol. Chem. | volume = 276 | issue = 11 | pages = 8341–9 | date = March 2001 | pmid = 11112773 | doi = 10.1074/jbc.M007116200 }}
23. ^{{cite journal | vauthors = Cao H, Courchesne WE, Mastick CC | title = A phosphotyrosine-dependent protein interaction screen reveals a role for phosphorylation of caveolin-1 on tyrosine 14: recruitment of C-terminal Src kinase | journal = J. Biol. Chem. | volume = 277 | issue = 11 | pages = 8771–4 | date = March 2002 | pmid = 11805080 | doi = 10.1074/jbc.C100661200 }}
24. ^{{cite journal | vauthors = Yan M, Zhang Z, Brady JR, Schilbach S, Fairbrother WJ, Dixit VM | title = Identification of a novel death domain-containing adaptor molecule for ectodysplasin-A receptor that is mutated in crinkled mice | journal = Curr. Biol. | volume = 12 | issue = 5 | pages = 409–13 | date = March 2002 | pmid = 11882293 | doi = 10.1016/s0960-9822(02)00687-5}}
25. ^{{cite journal | vauthors = Oukka M, Kim ST, Lugo G, Sun J, Wu LC, Glimcher LH | title = A mammalian homolog of Drosophila schnurri, KRC, regulates TNF receptor-driven responses and interacts with TRAF2 | journal = Mol. Cell | volume = 9 | issue = 1 | pages = 121–31 | date = January 2002 | pmid = 11804591 | doi = 10.1016/s1097-2765(01)00434-8}}
26. ^1 {{cite journal | vauthors = Devin A, Lin Y, Yamaoka S, Li Z, Karin M | title = The alpha and beta subunits of IkappaB kinase (IKK) mediate TRAF2-dependent IKK recruitment to tumor necrosis factor (TNF) receptor 1 in response to TNF | journal = Mol. Cell. Biol. | volume = 21 | issue = 12 | pages = 3986–94 | date = June 2001 | pmid = 11359906 | pmc = 87061 | doi = 10.1128/MCB.21.12.3986-3994.2001 }}
27. ^1 2 {{cite journal | vauthors = Li S, Wang L, Dorf ME | title = PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment and K63-linked polyubiquitination | journal = Mol. Cell | volume = 33 | issue = 1 | pages = 30–42 | date = January 2009 | pmid = 19150425 | pmc = 2643372 | doi = 10.1016/j.molcel.2008.11.023 }}
28. ^{{cite journal | vauthors = Ye X, Mehlen P, Rabizadeh S, VanArsdale T, Zhang H, Shin H, Wang JJ, Leo E, Zapata J, Hauser CA, Reed JC, Bredesen DE | title = TRAF family proteins interact with the common neurotrophin receptor and modulate apoptosis induction | journal = J. Biol. Chem. | volume = 274 | issue = 42 | pages = 30202–8 | date = October 1999 | pmid = 10514511 | doi = 10.1074/jbc.274.42.30202}}
29. ^{{cite journal | vauthors = Luftig MA, Cahir-McFarland E, Mosialos G, Kieff E|authorlink4= Elliott D. Kieff | title = Effects of the NIK aly mutation on NF-kappaB activation by the Epstein-Barr virus latent infection membrane protein, lymphotoxin beta receptor, and CD40 | journal = J. Biol. Chem. | volume = 276 | issue = 18 | pages = 14602–6 | date = May 2001 | pmid = 11278268 | doi = 10.1074/jbc.C100103200 }}
30. ^{{cite journal | vauthors = Baud V, Liu ZG, Bennett B, Suzuki N, Xia Y, Karin M | title = Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain | journal = Genes Dev. | volume = 13 | issue = 10 | pages = 1297–308 | date = May 1999 | pmid = 10346818 | pmc = 316725 | doi = 10.1101/gad.13.10.1297}}
31. ^{{cite journal | vauthors = Takaesu G, Kishida S, Hiyama A, Yamaguchi K, Shibuya H, Irie K, Ninomiya-Tsuji J, Matsumoto K | title = TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway | journal = Mol. Cell | volume = 5 | issue = 4 | pages = 649–58 | date = April 2000 | pmid = 10882101 | doi = 10.1016/s1097-2765(00)80244-0}}
32. ^{{cite journal | vauthors = Yuasa T, Ohno S, Kehrl JH, Kyriakis JM | title = Tumor necrosis factor signaling to stress-activated protein kinase (SAPK)/Jun NH2-terminal kinase (JNK) and p38. Germinal center kinase couples TRAF2 to mitogen-activated protein kinase/ERK kinase kinase 1 and SAPK while receptor interacting protein associates with a mitogen-activated protein kinase kinase kinase upstream of MKK6 and p38 | journal = J. Biol. Chem. | volume = 273 | issue = 35 | pages = 22681–92 | date = August 1998 | pmid = 9712898 | doi = 10.1074/jbc.273.35.22681}}
33. ^{{cite journal | vauthors = Shi CS, Leonardi A, Kyriakis J, Siebenlist U, Kehrl JH | title = TNF-mediated activation of the stress-activated protein kinase pathway: TNF receptor-associated factor 2 recruits and activates germinal center kinase related | journal = J. Immunol. | volume = 163 | issue = 6 | pages = 3279–85 | date = September 1999 | pmid = 10477597 | doi = }}
34. ^{{cite journal | vauthors = Darnay BG, Haridas V, Ni J, Moore PA, Aggarwal BB | title = Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase | journal = J. Biol. Chem. | volume = 273 | issue = 32 | pages = 20551–5 | date = August 1998 | pmid = 9685412 | doi = 10.1074/jbc.273.32.20551}}
35. ^{{cite journal | vauthors = Darnay BG, Ni J, Moore PA, Aggarwal BB | title = Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif | journal = J. Biol. Chem. | volume = 274 | issue = 12 | pages = 7724–31 | date = March 1999 | pmid = 10075662 | doi = 10.1074/jbc.274.12.7724}}
36. ^{{cite journal | vauthors = Galibert L, Tometsko ME, Anderson DM, Cosman D, Dougall WC | title = The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily | journal = J. Biol. Chem. | volume = 273 | issue = 51 | pages = 34120–7 | date = Dec 1998 | pmid = 9852070 | doi = 10.1074/jbc.273.51.34120}}
37. ^{{cite journal | vauthors = Kim HH, Lee DE, Shin JN, Lee YS, Jeon YM, Chung CH, Ni J, Kwon BS, Lee ZH | title = Receptor activator of NF-kappaB recruits multiple TRAF family adaptors and activates c-Jun N-terminal kinase | journal = FEBS Lett. | volume = 443 | issue = 3 | pages = 297–302 | date = January 1999 | pmid = 10025951 | doi = 10.1016/S0014-5793(98)01731-1}}
38. ^1 {{cite journal | vauthors = Tada K, Okazaki T, Sakon S, Kobarai T, Kurosawa K, Yamaoka S, Hashimoto H, Mak TW, Yagita H, Okumura K, Yeh WC, Nakano H | title = Critical roles of TRAF2 and TRAF5 in tumor necrosis factor-induced NF-kappa B activation and protection from cell death | journal = J. Biol. Chem. | volume = 276 | issue = 39 | pages = 36530–4 | date = September 2001 | pmid = 11479302 | doi = 10.1074/jbc.M104837200 }}
39. ^{{cite journal | vauthors = Xia P, Wang L, Moretti PA, Albanese N, Chai F, Pitson SM, D'Andrea RJ, Gamble JR, Vadas MA | title = Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling | journal = J. Biol. Chem. | volume = 277 | issue = 10 | pages = 7996–8003 | date = March 2002 | pmid = 11777919 | doi = 10.1074/jbc.M111423200 | pmc = 3234989 }}
40. ^{{cite journal | vauthors = Nomura F, Kawai T, Nakanishi K, Akira S | title = NF-kappaB activation through IKK-i-dependent I-TRAF/TANK phosphorylation | journal = Genes Cells | volume = 5 | issue = 3 | pages = 191–202 | date = March 2000 | pmid = 10759890 | doi = 10.1046/j.1365-2443.2000.00315.x}}
41. ^{{cite journal | vauthors = Pomerantz JL, Baltimore D | title = NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase | journal = EMBO J. | volume = 18 | issue = 23 | pages = 6694–704 | date = Dec 1999 | pmid = 10581243 | pmc = 1171732 | doi = 10.1093/emboj/18.23.6694 }}
42. ^1 2 3 4 {{cite journal | vauthors = Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G | title = A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway | journal = Nat. Cell Biol. | volume = 6 | issue = 2 | pages = 97–105 | date = February 2004 | pmid = 14743216 | doi = 10.1038/ncb1086 }}
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44. ^{{cite journal | vauthors = Song HY, Rothe M, Goeddel DV | title = The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 13 | pages = 6721–5 | date = June 1996 | pmid = 8692885 | pmc = 39093 | doi = 10.1073/pnas.93.13.6721}}
45. ^{{cite journal | vauthors = Xia XZ, Treanor J, Senaldi G, Khare SD, Boone T, Kelley M, Theill LE, Colombero A, Solovyev I, Lee F, McCabe S, Elliott R, Miner K, Hawkins N, Guo J, Stolina M, Yu G, Wang J, Delaney J, Meng SY, Boyle WJ, Hsu H | title = TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation | journal = J. Exp. Med. | volume = 192 | issue = 1 | pages = 137–43 | date = July 2000 | pmid = 10880535 | pmc = 1887716 | doi = 10.1084/jem.192.1.137}}
46. ^{{cite journal | vauthors = Hsu H, Solovyev I, Colombero A, Elliott R, Kelley M, Boyle WJ | title = ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5 | journal = J. Biol. Chem. | volume = 272 | issue = 21 | pages = 13471–4 | date = May 1997 | pmid = 9153189 | doi = 10.1074/jbc.272.21.13471}}
47. ^1 {{cite journal | vauthors = Shu HB, Takeuchi M, Goeddel DV | title = The tumor necrosis factor receptor 2 signal transducers TRAF2 and c-IAP1 are components of the tumor necrosis factor receptor 1 signaling complex | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 24 | pages = 13973–8 | date = November 1996 | pmid = 8943045 | pmc = 19479 | doi = 10.1073/pnas.93.24.13973}}
48. ^1 {{cite journal | vauthors = Hsu H, Huang J, Shu HB, Baichwal V, Goeddel DV | title = TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex | journal = Immunity | volume = 4 | issue = 4 | pages = 387–96 | date = April 1996 | pmid = 8612133 | doi = 10.1016/S1074-7613(00)80252-6}}
49. ^1 {{cite journal | vauthors = Hsu H, Shu HB, Pan MG, Goeddel DV | title = TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways | journal = Cell | volume = 84 | issue = 2 | pages = 299–308 | date = January 1996 | pmid = 8565075 | doi = 10.1016/S0092-8674(00)80984-8}}
50. ^1 {{cite journal | vauthors = Rothe M, Xiong J, Shu HB, Williamson K, Goddard A, Goeddel DV | title = I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 16 | pages = 8241–6 | date = August 1996 | pmid = 8710854 | pmc = 38654 | doi = 10.1073/pnas.93.16.8241}}
51. ^1 {{cite journal | vauthors = Marsters SA, Ayres TM, Skubatch M, Gray CL, Rothe M, Ashkenazi A | title = Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1 | journal = J. Biol. Chem. | volume = 272 | issue = 22 | pages = 14029–32 | date = May 1997 | pmid = 9162022 | doi = 10.1074/jbc.272.22.14029}}
52. ^{{cite journal | vauthors = Hostager BS, Bishop GA | title = Role of TNF receptor-associated factor 2 in the activation of IgM secretion by CD40 and CD120b | journal = J. Immunol. | volume = 168 | issue = 7 | pages = 3318–22 | date = April 2002 | pmid = 11907088 | doi = 10.4049/jimmunol.168.7.3318}}
53. ^{{cite journal | vauthors = Carpentier I, Coornaert B, Beyaert R | title = Smurf2 is a TRAF2 binding protein that triggers TNF-R2 ubiquitination and TNF-R2-induced JNK activation | journal = Biochem. Biophys. Res. Commun. | volume = 374 | issue = 4 | pages = 752–7 | date = October 2008 | pmid = 18671942 | doi = 10.1016/j.bbrc.2008.07.103 }}
54. ^{{cite journal | vauthors = Kuai J, Nickbarg E, Wooters J, Qiu Y, Wang J, Lin LL | title = Endogenous association of TRAF2, TRAF3, cIAP1, and Smac with lymphotoxin beta receptor reveals a novel mechanism of apoptosis | journal = J. Biol. Chem. | volume = 278 | issue = 16 | pages = 14363–9 | date = April 2003 | pmid = 12571250 | doi = 10.1074/jbc.M208672200 }}
55. ^{{cite journal | vauthors = Park YC, Ye H, Hsia C, Segal D, Rich RL, Liou HC, Myszka DG, Wu H | title = A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction | journal = Cell | volume = 101 | issue = 7 | pages = 777–87 | date = June 2000 | pmid = 10892748 | doi = 10.1016/S0092-8674(00)80889-2}}
56. ^{{cite journal | vauthors = Tsao DH, McDonagh T, Telliez JB, Hsu S, Malakian K, Xu GY, Lin LL | title = Solution structure of N-TRADD and characterization of the interaction of N-TRADD and C-TRAF2, a key step in the TNFR1 signaling pathway | journal = Mol. Cell | volume = 5 | issue = 6 | pages = 1051–7 | date = June 2000 | pmid = 10911999 | doi = 10.1016/S1097-2765(00)80270-1}}
57. ^{{cite journal | vauthors = Lee SY, Lee SY, Choi Y | title = TRAF-interacting protein (TRIP): a novel component of the tumor necrosis factor receptor (TNFR)- and CD30-TRAF signaling complexes that inhibits TRAF2-mediated NF-kappaB activation | journal = J. Exp. Med. | volume = 185 | issue = 7 | pages = 1275–85 | date = April 1997 | pmid = 9104814 | pmc = 2196258 | doi = 10.1084/jem.185.7.1275}}
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65. ^{{cite journal | vauthors = White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, ((Sanger Institute Mouse Genetics Project)), Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP | title = Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes | journal = Cell | volume = 154 | issue = 2 | pages = 452–64 | year = 2013 | pmid = 23870131 | doi = 10.1016/j.cell.2013.06.022 | pmc=3717207}}
66. ^1 {{cite web |url= http://www.immunophenotyping.org/data/search?keys=Traf2&field_gene_construct_tid=All |title=Infection and Immunity Immunophenotyping (3i) Consortium}}

Further reading

{{Refbegin}}
  • {{cite journal | vauthors = Wajant H, Henkler F, Scheurich P | title = The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators | journal = Cell. Signal. | volume = 13 | issue = 6 | pages = 389–400 | year = 2001 | pmid = 11384837 | doi = 10.1016/S0898-6568(01)00160-7 }}
  • {{cite journal | vauthors = Bradley JR, Pober JS | title = Tumor necrosis factor receptor-associated factors (TRAFs) | journal = Oncogene | volume = 20 | issue = 44 | pages = 6482–91 | year = 2001 | pmid = 11607847 | doi = 10.1038/sj.onc.1204788 }}
{{Refend}}{{PDB Gallery|geneid=7186}}{{Adaptor proteins}}{{Apoptosis signaling pathway}}{{Cytokine receptor modulators}}
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