| 释义 |
- Function
- Interactions
- References
- Further reading
{{Infobox_gene}}TNF receptor-associated factor 5 is a protein that in humans is encoded by the TRAF5 gene.[1] Function The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF) protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two TRAF-type zinc fingers. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor (TNF) receptor cytoplasmic domains and mediates TNF-induced activation. Alternate transcriptional splice variants have been characterized.[2] Interactions TRAF5 has been shown to interact with: {{div col|colwidth=20em}}- ASK1,[3][4]
- CD134,[5]
- CD30,[6]
- CD40,[7][8]
- RANK[9][10][11]
- TNFRSF13B,[12] and
- TNFRSF14.[13][14]
{{Div col end}} References 1. ^{{cite journal | vauthors = Tang XX, Pleasure DE, Ikegaki N | title = cDNA cloning, chromosomal localization, and expression pattern of EPLG8, a new member of the EPLG gene family encoding ligands of EPH-related protein-tyrosine kinase receptors | journal = Genomics | volume = 41 | issue = 1 | pages = 17–24 | date = Apr 1997 | pmid = 9126477 | pmc = | doi = 10.1006/geno.1997.4615 }}
2. ^{{cite web | title = Entrez Gene: TRAF5 TNF receptor-associated factor 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7188| accessdate = }}
3. ^{{cite journal | vauthors = Nishitoh H, Saitoh M, Mochida Y, Takeda K, Nakano H, Rothe M, Miyazono K, Ichijo H | title = ASK1 is essential for JNK/SAPK activation by TRAF2 | journal = Molecular Cell | volume = 2 | issue = 3 | pages = 389–95 | date = Sep 1998 | pmid = 9774977 | doi = 10.1016/s1097-2765(00)80283-x}}
4. ^{{cite journal | vauthors = Hoeflich KP, Yeh WC, Yao Z, Mak TW, Woodgett JR | title = Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1) | journal = Oncogene | volume = 18 | issue = 42 | pages = 5814–20 | date = Oct 1999 | pmid = 10523862 | doi = 10.1038/sj.onc.1202975 }}
5. ^{{cite journal | vauthors = Kawamata S, Hori T, Imura A, Takaori-Kondo A, Uchiyama T | title = Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation | journal = The Journal of Biological Chemistry | volume = 273 | issue = 10 | pages = 5808–14 | date = Mar 1998 | pmid = 9488716 | doi = 10.1074/jbc.273.10.5808}}
6. ^{{cite journal | vauthors = Aizawa S, Nakano H, Ishida T, Horie R, Nagai M, Ito K, Yagita H, Okumura K, Inoue J, Watanabe T | title = Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation | journal = The Journal of Biological Chemistry | volume = 272 | issue = 4 | pages = 2042–5 | date = Jan 1997 | pmid = 8999898 | doi = 10.1074/jbc.272.4.2042}}
7. ^{{cite journal | vauthors = Tsukamoto N, Kobayashi N, Azuma S, Yamamoto T, Inoue J | title = Two differently regulated nuclear factor kappaB activation pathways triggered by the cytoplasmic tail of CD40 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 4 | pages = 1234–9 | date = Feb 1999 | pmid = 9990007 | pmc = 15446 | doi = 10.1073/pnas.96.4.1234}}
8. ^{{cite journal | vauthors = Ishida TK, Tojo T, Aoki T, Kobayashi N, Ohishi T, Watanabe T, Yamamoto T, Inoue J | title = TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 18 | pages = 9437–42 | date = Sep 1996 | pmid = 8790348 | pmc = 38446 | doi = 10.1073/pnas.93.18.9437}}
9. ^{{cite journal | vauthors = Darnay BG, Haridas V, Ni J, Moore PA, Aggarwal BB | title = Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase | journal = The Journal of Biological Chemistry | volume = 273 | issue = 32 | pages = 20551–5 | date = Aug 1998 | pmid = 9685412 | doi = 10.1074/jbc.273.32.20551}}
10. ^{{cite journal | vauthors = Darnay BG, Ni J, Moore PA, Aggarwal BB | title = Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif | journal = The Journal of Biological Chemistry | volume = 274 | issue = 12 | pages = 7724–31 | date = Mar 1999 | pmid = 10075662 | doi = 10.1074/jbc.274.12.7724}}
11. ^{{cite journal | vauthors = Galibert L, Tometsko ME, Anderson DM, Cosman D, Dougall WC | title = The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily | journal = The Journal of Biological Chemistry | volume = 273 | issue = 51 | pages = 34120–7 | date = Dec 1998 | pmid = 9852070 | doi = 10.1074/jbc.273.51.34120}}
12. ^{{cite journal | vauthors = Xia XZ, Treanor J, Senaldi G, Khare SD, Boone T, Kelley M, Theill LE, Colombero A, Solovyev I, Lee F, McCabe S, Elliott R, Miner K, Hawkins N, Guo J, Stolina M, Yu G, Wang J, Delaney J, Meng SY, Boyle WJ, Hsu H | title = TACI is a TRAF-interacting receptor for TALL-1, a tumor necrosis factor family member involved in B cell regulation | journal = The Journal of Experimental Medicine | volume = 192 | issue = 1 | pages = 137–43 | date = Jul 2000 | pmid = 10880535 | pmc = 1887716 | doi = 10.1084/jem.192.1.137}}
13. ^{{cite journal | vauthors = Hsu H, Solovyev I, Colombero A, Elliott R, Kelley M, Boyle WJ | title = ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5 | journal = The Journal of Biological Chemistry | volume = 272 | issue = 21 | pages = 13471–4 | date = May 1997 | pmid = 9153189 | doi = 10.1074/jbc.272.21.13471}}
14. ^{{cite journal | vauthors = Marsters SA, Ayres TM, Skubatch M, Gray CL, Rothe M, Ashkenazi A | title = Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1 | journal = The Journal of Biological Chemistry | volume = 272 | issue = 22 | pages = 14029–32 | date = May 1997 | pmid = 9162022 | doi = 10.1074/jbc.272.22.14029}}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Wajant H, Henkler F, Scheurich P | title = The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators | journal = Cellular Signalling | volume = 13 | issue = 6 | pages = 389–400 | date = Jun 2001 | pmid = 11384837 | doi = 10.1016/S0898-6568(01)00160-7 }}
- {{cite journal | vauthors = Bradley JR, Pober JS | title = Tumor necrosis factor receptor-associated factors (TRAFs) | journal = Oncogene | volume = 20 | issue = 44 | pages = 6482–91 | date = Oct 2001 | pmid = 11607847 | doi = 10.1038/sj.onc.1204788 }}
- {{cite journal | vauthors = Nakano H, Oshima H, Chung W, Williams-Abbott L, Ware CF, Yagita H, Okumura K | title = TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor | journal = The Journal of Biological Chemistry | volume = 271 | issue = 25 | pages = 14661–4 | date = Jun 1996 | pmid = 8663299 | doi = 10.1074/jbc.271.25.14661 }}
- {{cite journal | vauthors = Ishida TK, Tojo T, Aoki T, Kobayashi N, Ohishi T, Watanabe T, Yamamoto T, Inoue J | title = TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 18 | pages = 9437–42 | date = Sep 1996 | pmid = 8790348 | pmc = 38446 | doi = 10.1073/pnas.93.18.9437 }}
- {{cite journal | vauthors = Bonaldo MF, Lennon G, Soares MB | title = Normalization and subtraction: two approaches to facilitate gene discovery | journal = Genome Research | volume = 6 | issue = 9 | pages = 791–806 | date = Sep 1996 | pmid = 8889548 | doi = 10.1101/gr.6.9.791 }}
- {{cite journal | vauthors = Aizawa S, Nakano H, Ishida T, Horie R, Nagai M, Ito K, Yagita H, Okumura K, Inoue J, Watanabe T | title = Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation | journal = The Journal of Biological Chemistry | volume = 272 | issue = 4 | pages = 2042–5 | date = Jan 1997 | pmid = 8999898 | doi = 10.1074/jbc.272.4.2042 }}
- {{cite journal | vauthors = Hsu H, Solovyev I, Colombero A, Elliott R, Kelley M, Boyle WJ | title = ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5 | journal = The Journal of Biological Chemistry | volume = 272 | issue = 21 | pages = 13471–4 | date = May 1997 | pmid = 9153189 | doi = 10.1074/jbc.272.21.13471 }}
- {{cite journal | vauthors = Marsters SA, Ayres TM, Skubatch M, Gray CL, Rothe M, Ashkenazi A | title = Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1 | journal = The Journal of Biological Chemistry | volume = 272 | issue = 22 | pages = 14029–32 | date = May 1997 | pmid = 9162022 | doi = 10.1074/jbc.272.22.14029 }}
- {{cite journal | vauthors = Nakano H, Shindo M, Yamada K, Yoshida MC, Santee SM, Ware CF, Jenkins NA, Gilbert DJ, Yagita H, Copeland NC, Okumura K | title = Human TNF receptor-associated factor 5 (TRAF5): cDNA cloning, expression and assignment of the TRAF5 gene to chromosome 1q32 | journal = Genomics | volume = 42 | issue = 1 | pages = 26–32 | date = May 1997 | pmid = 9177772 | doi = 10.1006/geno.1997.4697 }}
- {{cite journal | vauthors = Song HY, Régnier CH, Kirschning CJ, Goeddel DV, Rothe M | title = Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 94 | issue = 18 | pages = 9792–6 | date = Sep 1997 | pmid = 9275204 | pmc = 23270 | doi = 10.1073/pnas.94.18.9792 }}
- {{cite journal | vauthors = Kawamata S, Hori T, Imura A, Takaori-Kondo A, Uchiyama T | title = Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation | journal = The Journal of Biological Chemistry | volume = 273 | issue = 10 | pages = 5808–14 | date = Mar 1998 | pmid = 9488716 | doi = 10.1074/jbc.273.10.5808 }}
- {{cite journal | vauthors = Mizushima S, Fujita M, Ishida T, Azuma S, Kato K, Hirai M, Otsuka M, Yamamoto T, Inoue J | title = Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5) | journal = Gene | volume = 207 | issue = 2 | pages = 135–40 | date = Jan 1998 | pmid = 9511754 | doi = 10.1016/S0378-1119(97)00616-1 }}
- {{cite journal | vauthors = Akiba H, Nakano H, Nishinaka S, Shindo M, Kobata T, Atsuta M, Morimoto C, Ware CF, Malinin NL, Wallach D, Yagita H, Okumura K | title = CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase | journal = The Journal of Biological Chemistry | volume = 273 | issue = 21 | pages = 13353–8 | date = May 1998 | pmid = 9582383 | doi = 10.1074/jbc.273.21.13353 }}
- {{cite journal | vauthors = McCarthy JV, Ni J, Dixit VM | title = RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase | journal = The Journal of Biological Chemistry | volume = 273 | issue = 27 | pages = 16968–75 | date = Jul 1998 | pmid = 9642260 | doi = 10.1074/jbc.273.27.16968 }}
- {{cite journal | vauthors = Pullen SS, Miller HG, Everdeen DS, Dang TT, Crute JJ, Kehry MR | title = CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization | journal = Biochemistry | volume = 37 | issue = 34 | pages = 11836–45 | date = Aug 1998 | pmid = 9718306 | doi = 10.1021/bi981067q }}
- {{cite journal | vauthors = Wong BR, Josien R, Lee SY, Vologodskaia M, Steinman RM, Choi Y | title = The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor | journal = The Journal of Biological Chemistry | volume = 273 | issue = 43 | pages = 28355–9 | date = Oct 1998 | pmid = 9774460 | doi = 10.1074/jbc.273.43.28355 }}
- {{cite journal | vauthors = Nishitoh H, Saitoh M, Mochida Y, Takeda K, Nakano H, Rothe M, Miyazono K, Ichijo H | title = ASK1 is essential for JNK/SAPK activation by TRAF2 | journal = Molecular Cell | volume = 2 | issue = 3 | pages = 389–95 | date = Sep 1998 | pmid = 9774977 | doi = 10.1016/S1097-2765(00)80283-X }}
- {{cite journal | vauthors = Tsukamoto N, Kobayashi N, Azuma S, Yamamoto T, Inoue J | title = Two differently regulated nuclear factor kappaB activation pathways triggered by the cytoplasmic tail of CD40 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 4 | pages = 1234–9 | date = Feb 1999 | pmid = 9990007 | pmc = 15446 | doi = 10.1073/pnas.96.4.1234 }}
{{refend}}{{Adaptor proteins}}{{Cytokine receptor modulators}} |