| 词条 | Transcription factor II D |
| 释义 |
Transcription factor II D (TFIID) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex. RNA polymerase II holoenzyme is a form of eukaryotic RNA polymerase II that is recruited to the promoters of protein-coding genes in living cells. It consists of RNA polymerase II, a subset of general transcription factors, and regulatory proteins known as SRB proteins. Before the start of transcription, the transcription Factor II D (TFIID) complex binds to the TATA box in the core promoter of the gene. Functions
StructureTFIID is itself composed of TBP and several subunits called TATA-binding protein Associated Factors (TBP-associated factors, or TAFs). In a test tube, only TBP is necessary for transcription at promoters that contain a TATA box.[1] TAFs, however, add promoter selectivity, especially if there is no TATA box sequence for TBP to bind to.[2] TAFs are included in two distinct complexes, TFIID[3] and B-TFIID.[4] The TFIID complex is composed of TBP and more than eight TAFs. But, the majority of TBP is present in the B-TFIID complex, which is composed of TBP and TAFII170 (BTAF1) in a 1:1 ratio.[5] TFIID and B-TFIID are not equivalent, since transcription reactions utilizing TFIID are responsive to gene specific transcription factors such as SP1, while reactions reconstituted with B-TFIID are not.[5] Subunits in the TFIID complex include:[1]
See also
References1. ^1 {{cite journal | title = Transcription of eukaryotic protein-coding genes | journal = Annu. Rev. Genet. | volume = 34 | issue = | pages = 77–137 | year = 2000 | pmid = 11092823 | doi = 10.1146/annurev.genet.34.1.77 | last1 = Lee | first1 = Tong Ihn | last2 = Young | first2 = Richard A.}} 2. ^{{cite journal|last1=Louder|first1=RK|last2=He|first2=Y|last3=López-Blanco|first3=JR|last4=Fang|first4=J|last5=Chacón|first5=P|last6=Nogales|first6=E|title=Structure of promoter-bound TFIID and model of human pre-initiation complex assembly|journal=Nature|date=2016|volume=531|pages=604-609|doi=10.1038/nature17394|pmc=4856295}} 3. ^{{ cite journal | doi =10.1016/0092-8674(81)90019-2| title = Isolation of co-activators associated with the TATA-binding protein that mediate transcriptional activation| journal = Cell|date=Aug 1991|volume = 66| pages = 563–576| pmid = 1907890 | last1 =Dynlacht | first1 =Brian David | last2 =Hoey | first2 =Timothy | last3 =Tjian | first3 =Robert | issue =3}} 4. ^{{ cite web |title=NCBI Entrez GeneID: 9044 BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa (Mot1 homolog, S. cerevisiae) |url=https://www.ncbi.nlm.nih.gov/gene/9044 }} 5. ^1 {{ cite journal |doi=10.1073/pnas.89.17.8140 |title=Composition of transcription factor B-TFIID |journal=Proc Natl Acad Sci USA |date=Sep 1992 |volume=89 |issue= 17|pages=8140–4 |url=http://www.pnas.org/content/89/17/8140.full.pdf+html |pmid=1387711 |pmc=49872 |last1=Timmers |first1=H. |last2=Meyers |first2=RE |last3=Sharp |first3=PA }} 6. ^{{cite journal |last1=Duttke |first1=SH |title=Evolution and diversification of the basal transcription machinery. |journal=Trends in biochemical sciences |date=March 2015 |volume=40 |issue=3 |pages=127-9 |doi=10.1016/j.tibs.2015.01.005 |pmid=25661246 |pmc=4410091}} External links
4 : Gene expression|Molecular genetics|Proteins|Transcription factors |
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