| 词条 | Transcription factor II E |
| 释义 |
| Name = general transcription factor IIE, polypeptide 1, alpha 56kDa | caption = | image = | width = | HGNCid = 4650 | Symbol = GTF2E1 | AltSymbols = TF2E1 | EntrezGene = 2960 | OMIM = 189962 | RefSeq = NM_005513 | UniProt = P29083 | PDB = | ECnumber = | Chromosome = 3 | Arm = q | Band = 21 | LocusSupplementaryData = -q24 }}{{infobox protein | Name = general transcription factor IIE, polypeptide 2, beta 34kDa | caption = | image = | width = | HGNCid = 4651 | Symbol = GTF2E2 | AltSymbols = TF2E2 | EntrezGene = 2961 | OMIM = 189964 | RefSeq = NM_002095 | UniProt = P29084 | PDB = | ECnumber = | Chromosome = 8 | Arm = p | Band = 12 | LocusSupplementaryData = }}Transcription factor II E (TFIIE) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex.[1] It is a tetramer of two alpha and two beta chains and interacts with TAF6/TAFII80, ATF7IP, and varicella-zoster virus IE63 protein.[2] TFIIE recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.[2] Transcription factor II E is encoded by the GTF2E1 and GTF2E2 genes.[3][4][5][6] TFIIE is thought to be involved in DNA melting at the promoter: it contains a zinc ribbon motif that can bind single stranded DNA.[7] See also
References1. ^{{cite book | author = Lewin, Benjamin | title = Genes VIII | publisher = Pearson Prentice Hall | location = Upper Saddle River, NJ | year = 2004 | pages = 636–637 | isbn = 0-13-144946-X | oclc = | doi = }} 2. ^1 {{cite web|url=https://www.uniprot.org/uniprot/P29083|title=UniProtKB - P29083 (T2EA_HUMAN)|website=UniProt|accessdate=2016-10-19}} 3. ^{{cite journal | vauthors = Ohkuma Y, Hashimoto S, Roeder RG, Horikoshi M | title = Identification of two large subdomains in TFIIE-alpha on the basis of homology between Xenopus and human sequences | journal = Nucleic Acids Res. | volume = 20 | issue = 21 | pages = 5838 | year = 1992 | pmid = 1454543 | pmc = 334425 | doi = 10.1093/nar/20.21.5838| issn = }} 4. ^{{cite journal | vauthors = Heng HH, Xiao H, Shi XM, Greenblatt J, Tsui LC | title = Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome | journal = Hum. Mol. Genet. | volume = 3 | issue = 1 | pages = 61–4 | year = 1994 | pmid = 8162052 | doi = 10.1093/hmg/3.1.61| issn = }} 5. ^{{cite journal | vauthors = Sumimoto H, Ohkuma Y, Sinn E, Kato H, Shimasaki S, Horikoshi M, Roeder RG | title = Conserved sequence motifs in the small subunit of human general transcription factor TFIIE | journal = Nature | volume = 354 | issue = 6352 | pages = 401–4 | year = 1991 | pmid = 1956404 | doi = 10.1038/354401a0 | issn = }} 6. ^{{cite journal | vauthors = Ohkuma Y, Sumimoto H, Hoffmann A, Shimasaki S, Horikoshi M, Roeder RG | title = Structural motifs and potential sigma homologies in the large subunit of human general transcription factor TFIIE | journal = Nature | volume = 354 | issue = 6352 | pages = 398–401 |date=December 1991 | pmid = 1956403 | doi = 10.1038/354398a0 | url = | issn = }} 7. ^{{cite journal | vauthors = Lee TI, Young RA | title = Transcription of eukaryotic protein-coding genes | journal = Annu. Rev. Genet. | volume = 34 | issue = | pages = 77–137 | year = 2000 | pmid = 11092823 | doi = 10.1146/annurev.genet.34.1.77}} External links
4 : Molecular genetics|Proteins|Gene expression|Transcription factors |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。