词条 | Tributyltin |
释义 |
Chemical propertiesTBT compounds are organotin compounds, with three butyl groups covalently bonded to a tin(IV) centre.[3] A general formula for these compounds is (n-C4H9)3Sn-X. The X group is typically an electronegative, such as chloride, hydroxide, or carboxylate.[4] When introduced into a marine or aquatic environment, TBT adheres to bed sediments because of its high specific gravity and low solubility. However, the adsorption of TBT to sediments is reversible and depends on pH. Studies have shown that 95% of TBT can be released from the sediments back into the aquatic environment. This absorption process can complicate quantification of TBT in an environment, since its concentration in the water is not representative of its availability.[1] UsesTributyltin compounds are biocides. TBT´s antifouling properties were discovered in the 1950s in the Netherlands by van der Kerk and coworkers. It prevents microrganisms to settle on the hull of a ship and poisons the organisms that do.[5] By the mid 1960s it had become the most popular anti-fouling paint around the globe.[2] TBT was mixed into paints to extend the life of antifouling coatings, and ships were able to continue operations for a longer time frame. The paints ensured fuel efficiency and delayed costly ship repairs. It is also relatively inexpensive.[6] TBT is also an ingredient in some disinfectants, for example in combination with quaternary ammonium compounds.[7] ToxicityThe effects of antifouling paint go beyond the organisms that it is intended to kill. By poisoning barnacles, algae, and other organisms at the bottom of the food chain, TBT is biomagnified up the marine predators' food web. It has been shown to harmfully affect many layers of the ecosystem, including invertebrates and vertebrates, even humans. Toxic effects in some species occur at 1 nano-gram per liter of water.[8] BioaccumulationAlthough an effective biocide, tributyltin was wrongly deemed safe environmentally. TBT has a half-life of one or two weeks in marine water.[3] When it accumulates in sediments its half life is about 2 years. TBT often bonds to suspended material and sediments, where it can remain and be released for up to 30 years.[12][9] InvertebratesTBT has been shown to affect invertebrate development. Marine snails, such as the dog whelk (Nucella lapillus), has often been used as an indicator species.[10] TBT disrupts their endocrine system by inhibiting cytochrome P450 molecule. Among its myriad functions, P450 converts androgen, which has male-hormone properties, into oestrogen, which has female-hormone properties. This inhibition leads to masculinization in females, because the androgen levels are higher than normal. Since fewer fertile females are then available for mating, the population begins to decline, thereby seriously impacting the balance of the ecosystem.[8][11] Another indicator species is Chironomus riparius, a species of non-biting midge, which has been used to test the effects of TBT on development and reproduction at sublethal concentrations found in marine environments. It was found that only 0.05 ng/ml range is enough to have developmental effects on their larvae, and 10-100 ng/l was enough to seriously offset the female to male ratio in the population. At 10 ng/l females were at 55.6% of the population and 85.7% at 100 ng/l. These results are interesting because unlike the masculinization of the stengoglassan gastropods, this experiment shows feminization.[4] VertebratesVertebrates become affected by the waters contamined with TBT as well as by consuming organisms that have already been poisoned. Oryzias latipes, commonly called Japanese rice fish, has been used as a model vertebrate organism to test for effects of TBT at developmental stages of the embryo. It was observed that developmental rate was slowed by TBT in a concentration-related manner and that tail abnormalities occurred.[8] Illustrating the infiltration of TBT in the food chain, one study showed that most samples of skipjack tuna tested positive for presence of TBT. Tuna from waters around developing Asian nations had particularly high levels of TBT. Regulation of TBT is not enforced in Asia as rigorously as in Europe or US.[12] Studies have shown that TBT is detrimental to the immune system. Research shows that TBT reduces resistance to infection in fish which live on the seabed and are exposed to high levels of TBT. These areas tend to have silty sediment like harbours and estuaries.[6] TBT compounds have been described to interfere with glucocorticoid metabolism in the liver, by inhibiting the activity of the enzyme 11beta-hydroxysteroiddehydrogenase type 2, which converts cortisol to cortisone.[4] MammalsTBT can enter the diet of humans and other mammals. As of 2008 high levels of tributyltin had been detected in the livers of sea otters (Enhydra lutris) and stranded bottlenose dolphins.[13] Otters dying of infectious causes tended to have higher levels of tissue butyltins than those dying of trauma or other causes.[14] TBT has been shown to lead to immunosuppression in sea-otters and dolphins. TBT has also been linked to hearing loss in mammalian top predators such as toothed whales.[15][16] RegulationBans on TBT on boats less than 25 metres long first started in the 1980s. In 1990, the Marine Environment Protection Committee adopted Resolution MEPC 46(30), which recommended that the Government eliminate the use of TBT-containing antifouling paints on smaller vessels. This resolution was intended to be a temporary restriction until the International Maritime Organization could implement a ban of TBT anti-fouling agents for ships. Several countries followed, and in 1997 Japan banned the production of TBT-based anti-fouling paints.[6] In 2008 organotin compounds acting as biocide like TBT compounds were banned in anti-fouling paint and included in the Rotterdam Convention[17] and have been banned by the International Convention on the Control of Harmful Anti-fouling Systems on Ships of the International Maritime Organization.[6] It states that ships cannot bear organotin compounds on their hulls or external parts or surfaces, unless there is a coating that forms a barrier so that organotin compounds cannot leach out to reduce exposure by allowing recovery to occur.[1] Violations of the ban on TBTEven though banned by some international agencies, TBT anti-fouling paints are still used in countries with poor regulation enforcement, as in the Caribbean.[18] US violationsIn November, 2018, the US Dep't of Justice announced that three people they had charged and arrested in NJ for manufacturing and selling tributyltin based marine paint had pleaded guilty. Sentencing is scheduled for Feb., 2019.[19] See also
References1. ^1 2 {{cite journal|last=Antizar-Ladislao|first=Blanca|title=Environmental levels, toxicity and human exposure to tributyltin (TBT)-contaminated marine environment. A review|journal=Environment International|date=Feb 2008|volume=34|issue=2|pages=292–308|pmid=17959247|url=http://www.sciencedirect.com/science/article/pii/S0160412007001845|accessdate=Mar 12, 2014|doi=10.1016/j.envint.2007.09.005}} 2. ^1 {{cite book|last=Konstantinou|first=Ioannis|title=Antifouling Paint Biocides|date=Feb 22, 2006|publisher=Springer|pages=1}} 3. ^1 Davies, Alwyn George. (2004) Organotin Chemistry, 2nd Edition Weinheim: Wiley-VCH. {{ISBN|978-3-527-31023-4}} 4. ^1 2 {{cite book|last=Mora|first=ed. by Stephen J. De|title=Tributyltin : case study of an environmental contaminant|year=1996|publisher=Cambridge Univ. Press|location=Cambridge [u.a.]|isbn=978-0521470469|edition=1. publ.}} 5. ^{{cite web|last=Walmsley|first=Simon|title=Tributyltin pollution on a global scale. An overview of relevant and recent research: impacts and issues.|url=http://assets.wwf.no/downloads/tbt_global_review_wwf_uk_oct_2006.pdf|date= October 2006| pages=54|publisher=WWF|accessdate=2014-04-02}} 6. ^1 2 3 {{cite news | url=http://www.imo.org/OurWork/Environment/Anti-foulingSystems/Documents/FOULING2003.pdf | title=Focus on IMO - Anti-fouling systems | publisher=International Maritime Organisation|pages=31|date=2003}} 7. ^Steritech Concentrated Antimicrobial Solution brochure, accessed 02 December 2014 8. ^1 2 {{cite web|last=Walmsley|first=Simon|title=Tributyltin pollution on a global scale. An overview of relevant and recent research: impacts and issues.|url=http://assets.wwf.no/downloads/tbt_global_review_wwf_uk_oct_2006.pdf|publisher=WWF UK}} 9. ^1 {{cite book|last=Champ|first=Michael|title=Organotin: Environmental Fate and Effects|date=Sep 30, 1996|publisher=Springer|pages=469|url=https://books.google.com/?id=kA9AkPpAkxgC&dq=tbt+half+life+long|isbn=9780412582400}} 10. ^{{cite journal|last1=Gibbs|first1=P. E.|last2=Bryan|first2=G. W.|last3=Pascoe|first3=P. L.|last4=Burt|first4=G. R.|title=The use of the dog-whelk, Nucella lapillus, as an indicator of tributyltin (TBT) contamination|journal=Journal of the Marine Biological Association of the United Kingdom|date=11 May 2009|volume=67|issue=3|pages=507|doi=10.1017/S0025315400027260}} 11. ^{{cite journal|last1=Gibbs|first1=P. E.|last2=Bryan|first2=G. W.|title=Reproductive Failure in Populations of the Dog-Whelk, Nucella Lapillus, Caused by Imposex Induced by Tributyltin from Antifouling Paints|journal=Journal of the Marine Biological Association of the United Kingdom|date=11 May 2009|volume=66|issue=4|pages=767|doi=10.1017/S0025315400048414}} 12. ^{{cite web|last=Down|first=Steve|title=Tuna is attuned to tin|url=http://www.separationsnow.com/details/ezine/sepspec503ezine/Tuna-is-attuned-to-tin.html?tzcheck=1|work=Ezine|accessdate=2014-04-28}} 13. ^{{cite journal |vauthors=Murata S, Takahashi S, Agusa T, Thomas NJ, Kannan K, Tanabe S |title=Contamination status and accumulation profiles of organotins in sea otters (Enhydra lutris) found dead along the coasts of California, Washington, Alaska (USA), and Kamchatka (Russia) |journal=Marine Pollution Bulletin |volume=56 |issue=4 |pages=641–9 |date=April 2008 |pmid=18304586 |doi=10.1016/j.marpolbul.2008.01.019 |url=http://linkinghub.elsevier.com/retrieve/pii/S0025-326X(08)00025-8}} 14. ^Kannan et al. 1998. Butyltin residues in Southern sea otters (Enhydra lutris nereis) found dead along California coastal waters. Environ. Sci. Technol.. 32:1169-1175 15. ^{{cite journal|title=Control of Mammalian Cochlear Amplification by Chloride Anions |author1=Santos-Sacchi Joseph |author2=Song Lei |author3=Zheng Jiefu |author4=Nuttall Alfred L |url=http://www.jneurosci.org/cgi/content/full/26/15/3992 |date=2006-04-12 |journal=Journal of Neuroscience |volume=26 |issue=15 |pages=3992–3998 |doi=10.1523/JNEUROSCI.4548-05.2006 |pmid=16611815 }} 16. ^{{cite news |author=Matt Apuzzo |url=http://www.cbsnews.com/stories/2005/01/28/tech/main670083.shtml |title=Whale Deafness Linked To Chemical |publisher=Associated Press via CBS News |date=2005-01-28 |accessdate=2008-07-30}} 17. ^{{cite news|url=http://www.pic.int/Portals/5/DGDs/DGD_TBT_EN.pdf|title=Decision Guidance Document for Tributyltin Compounds|last=Secretariat for the Rotterdam Convention on the Prior Informed Consent Procedure for Certain Hazardous Chemicals and Pesticides in International Trade|date=1 February 2009|publisher=United Nations Environment Programme|accessdate=2013-01-04}} 18. ^{{cite web|title=Persistent Organic Pollutants (POPs) and Pesticides|url=http://www.cep.unep.org/publications-and-resources/marine-and-coastal-issues-links/persistent-organic-pollutants-pops-and-pesticides|work=The Caribbean Environment Programme|accessdate=2014-04-01}} 19. ^https://www.justice.gov/opa/pr/three-new-jersey-men-plead-guilty-illegal-production-and-distribution-pesticides External links
3 : Pesticides|Endocrine disruptors|Organotin compounds |
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