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词条 Trichodiene synthase
释义

  1. Structural studies

  2. References

{{enzyme
| Name = trichodiene synthase
| EC_number = 4.2.3.6
| CAS_number = 101915-76-8
| IUBMB_EC_number = 4/2/3/6
| GO_code = 0045482
| image =
| width =
| caption =
}}

In enzymology, a trichodiene synthase ({{EC number|4.2.3.6}}) is an enzyme that catalyzes the chemical reaction

trans,trans-farnesyl diphosphate trichodiene + diphosphate

Hence, this enzyme has one substrate, trans,trans-farnesyl diphosphate, and two products, trichodiene and diphosphate.

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is trans,trans-farnesyl-diphosphate diphosphate-lyase (cyclizing, trichodiene-forming). Other names in common use include trichodiene synthetase, sesquiterpene cyclase, and trans,trans-farnesyl-diphosphate sesquiterpenoid-lyase. This enzyme participates in terpenoid biosynthesis.

Structural studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1YJ4}}, {{PDB link|1YYQ}}, {{PDB link|1YYR}}, {{PDB link|1YYS}}, {{PDB link|1YYT}}, {{PDB link|1YYU}}, {{PDB link|2AEK}}, {{PDB link|2AEL}}, and {{PDB link|2AET}}.

References

  • {{cite journal | vauthors = Hohn TM, Vanmiddlesworth F | date = 1986 | title = Purification and characterization of the sesquiterpene cyclase trichodiene synthetase from Fusarium sporotrichioides | journal = Arch. Biochem. Biophys. | volume = 251 | pages = 756–61 | pmid = 3800398 | doi = 10.1016/0003-9861(86)90386-3 | issue = 2 | url = https://naldc-legacy.nal.usda.gov/naldc/download.xhtml?id=23897&content=PDF }}
{{Carbon-oxygen lyases}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{4.2-enzyme-stub}}

2 : EC 4.2.3|Enzymes of known structure

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