| 词条 | TrkB IRES |
| 释义 |
| Name = TrkB IRES | image = RF00547.jpg | width = | caption = Predicted secondary structure and sequence conservation of IRES_TrkB | Symbol = IRES_TrkB | AltSymbols = | Rfam = RF00547 | miRBase = | miRBase_family = | RNA_type = Cis-reg; IRES | Tax_domain = Eukaryota | GO = {{GO|0043022}} | SO = {{SO|0000243}} | CAS_number = | EntrezGene = | HGNCid = | OMIM = | PDB = | RefSeq = | Chromosome = | Arm = | Band = | LocusSupplementaryData = }} The TrkB internal ribosome entry site (IRES) is an RNA element which is present in the 5' UTR sequence of the mRNA. TrkB is a neurotrophin receptor which is essential for the development and maintenance of the nervous system. The internal ribosome entry site IRES element allows cap-independent translation of TrkB which may be needed for efficient translation in neuronal dendrites.[1] See also
References1. ^{{cite journal | last = Dobson | first = T |author2=Minic A |author3=Nielsen K |author4=Amiott E |author5=Krushel L | year = 2005 | title = Internal initiation of translation of the TrkB mRNA is mediated by multiple regions within the 5' leader | journal = Nucleic Acids Res | volume = 33 | pages = 2929–2941 | pmid = 15908588 | doi = 10.1093/nar/gki605 | issue = 9 | pmc = 1133793}} External links
1 : Cis-regulatory RNA elements |
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