| 词条 | Tromantadine |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 470617884 | IUPAC_name = N-(1-adamantyl)-2-[2-(dimethylamino)ethoxy]acetamide | image = Tromantadine.svg | alt = Skeletal formula | tradename = Viru-Merz | Drugs.com = {{drugs.com|international|tromantadine}} | pregnancy_category = | legal_US = Not FDA-approved | legal_status = OTC (RU) | routes_of_administration = Topical (gel) | bioavailability = | metabolism = | excretion = | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 53783-83-8 | ATC_prefix = D06 | ATC_suffix = BB02 | ATC_supplemental = {{ATC|J05|AC03}} | PubChem = 64377 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 57947 | NIAID_ChemDB = 007760 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = H191JFG8WA | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D07199 | C=16 | H=28 | N=2 | O=2 | molecular_weight = 280.406 g/mol | SMILES = O=C(NC13CC2CC(CC(C1)C2)C3)COCCN(C)C | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C16H28N2O2/c1-18(2)3-4-20-11-15(19)17-16-8-12-5-13(9-16)7-14(6-12)10-16/h12-14H,3-11H2,1-2H3,(H,17,19) | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = UXQDWARBDDDTKG-UHFFFAOYSA-N }}Tromantadine is an antiviral medicine used to treat herpes simplex virus. It is available in a topical gel under trade names Viru-Merz and Viru-Merz Serol. Its performance is similar to aciclovir.[1][2] Like rimantadine, amantadine, and adapromine, tromantadine is a derivative of adamantane. MechanismTromantadine inhibits the early and late events in the virus replication cycle.[3] It changes the glycoproteins of the host cells, therefore impeding the absorption of the virus. It inhibits penetration of the virus. It also prevents uncoating of the virions. References1. ^{{Cite journal|last=Ostheimer|first=K. E.|last2=Busch|first2=T.|last3=Görtelmeyer|first3=R.|last4=Hahn|first4=K. D.|date=September 1989|title=Randomized double-blind trial of tromantadine versus aciclovir in recurrent herpes orofacialis|journal=Arzneimittel-Forschung|volume=39|issue=9|pages=1152–1155|issn=0004-4172|pmid=2686658}} 2. ^{{Cite journal|last=Diezel|first=W.|last2=Michel|first2=G.|last3=Görtelmeyer|first3=R.|last4=Ostheimer|first4=K. E.|date=April 1993|title=Efficacy of tromantadine and aciclovir in the topical treatment of recurrent herpes orofacialis. Comparison in a clinical trial|journal=Arzneimittel-Forschung|volume=43|issue=4|pages=491–496|issn=0004-4172|pmid=8494582}} 3. ^{{cite journal |vauthors=Rosenthal KS, Sokol MS, Ingram RL, Subramanian R, Fort RC |title=Tromantadine: inhibitor of early and late events in herpes simplex virus replication |journal=Antimicrob. Agents Chemother. |volume=22 |issue=6 |pages=1031–6 |date=December 1982 |pmid=6297383 |pmc=185716 |doi= 10.1128/aac.22.6.1031|url=http://aac.asm.org/cgi/pmidlookup?view=long&pmid=6297383}} External links
4 : Anti-herpes virus drugs|Adamantanes|Acetamides|Amines |
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