| 词条 | Troxerutin |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 447983598 | IUPAC_name = 2-[3,4-bis(2-hydroxyethoxy)phenyl]-5-hydroxy-7-(2-hydroxyethoxy)-4-oxo-4H-chromen-3-yl 6-O-(6-deoxy-β-D-mannopyranosyl)-β-D-glucopyranoside | image = Troxerutin.svg | tradename = | Drugs.com = {{drugs.com|international|troxerutin}} | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 7085-55-4 | ATC_prefix = C05 | ATC_suffix = CA04 | PubChem = 9896814 | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 3182320 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | KEGG = D07180 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 7Y4N11PXO8 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 4589027 | C=33 | H=42 | O=19 | molecular_weight = 742.67518 g/mol | smiles = C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)OC[C@@H]2[C@H]([C@@H]([C@H]([C@@H](O2)Oc3c(=O)c4c(cc(cc4oc3c5ccc(c(c5)OCCO)OCCO)OCCO)O)O)O)O)O)O)O | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C33H42O19/c1-14-23(38)26(41)28(43)32(49-14)48-13-21-24(39)27(42)29(44)33(51-21)52-31-25(40)22-17(37)11-16(45-7-4-34)12-20(22)50-30(31)15-2-3-18(46-8-5-35)19(10-15)47-9-6-36/h2-3,10-12,14,21,23-24,26-29,32-39,41-44H,4-9,13H2,1H3/t14-,21+,23-,24+,26+,27-,28+,29+,32+,33-/m0/s1 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = IYVFNTXFRYQLRP-VVSTWUKXSA-N | synonyms = Hydroxyethylrutoside (HER) Pherarutin Trihydroxyethylrutin 3',4',7-Tris[O-(2-hydroxyethyl)]rutin }} Troxerutin is a flavonol, a type of flavonoid, derived from rutin.[1] It is more accurately a hydroxyethylrutoside. It can be isolated from Sophora japonica, the Japanese pagoda tree. It is used as a vasoprotective.[3] Troxerutin has been shown in mice to reverse CNS insulin resistance and reduce reactive oxygen species induced by a high-cholesterol diet.[4] References1. ^{{cite journal|last1=Zhang |first1=ZF|last2=Fan |first2=SH|last3=Zheng |first3=YL|last4=Lu |first4=J|last5=Wu |first5=DM|last6=Shan |first6=Q|last7=Hu |first7=B|title=Troxerutin improves hepatic lipid homeostasis by restoring NAD(+)-depletion-mediated dysfunction of lipin 1 signaling in high-fat diet-treated mice.|journal=Biochemical Pharmacology|volume=91|issue=1|year=2014|page=74-86|doi=10.1016/j.bcp.2014.07.002|pmid=25026599}} {{Flavonol}}{{Vasoprotectives}}{{cardiovascular-drug-stub}}2. ^ 3. ^{{Cite journal | last1 = Riccioni | first1 = C. | last2 = Sarcinella | first2 = R. | last3 = Izzo | first3 = A. | last4 = Palermo | first4 = G. | last5 = Liguori | first5 = M. | title = Effectiveness of Troxerutin in association with Pycnogenol in the pharmacological treatment of venous insufficiency | journal = Minerva cardioangiologica | volume = 52 | issue = 1 | pages = 43–48 | year = 2004 | pmid = 14765037}} 4. ^{{Cite journal | last1 = Lu | first1 = J. | last2 = Wu | first2 = D. -M. | last3 = Zheng | first3 = Z. -H. | last4 = Zheng | first4 = Y. -L. | last5 = Hu | first5 = B. | last6 = Zhang | first6 = Z. -F. | doi = 10.1093/brain/awq376 | title = Troxerutin protects against high cholesterol-induced cognitive deficits in mice | journal = Brain | volume = 134 | issue = 3 | pages = 783–797 | year = 2011 | pmid = 21252113 | pmc = }} 3 : Quercetin glycosides|Flavonol rutinosides|Phenol ethers |
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