| 词条 | Tryptoline |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 470618432 | ImageFile = Tryptoline structure.png | ImageSize = | IUPACName = 1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole | OtherNames = Noreleagnine Tetrahydronorharman 2,3,4,9-Tetrahydro-1H-β-carboline |Section1={{Chembox Identifiers | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 96979 | InChI = 1/C11H12N2/c1-2-4-10-8(3-1)9-5-6-12-7-11(9)13-10/h1-4,12-13H,5-7H2 | InChIKey = CFTOTSJVQRFXOF-UHFFFAOYAW | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 269236 | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C11H12N2/c1-2-4-10-8(3-1)9-5-6-12-7-11(9)13-10/h1-4,12-13H,5-7H2 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = CFTOTSJVQRFXOF-UHFFFAOYSA-N | CASNo_Ref = {{cascite|changed|??}} | CASNo = 16502-01-5 | PubChem = 107838 | SMILES = c1ccc2c(c1)c3c([nH]2)CNCC3 }} |Section2={{Chembox Properties | Formula = C11H12N2 | MolarMass = 172.226 g/mol | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = |Section3={{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }} Tryptoline, also known as tetrahydro-β-carboline and tetrahydronorharmane, is a natural organic derivative of beta-carboline. It is an alkaloid chemically related to tryptamines. Derivatives of tryptoline have a variety of pharmacological properties and are known collectively as tryptolines. Pharmacology{{unreferenced section|date=May 2018}}Many tryptolines are competitive selective inhibitors of the enzyme monoamine oxidase type A (MAO-A). 5-Hydroxytryptoline and 5-methoxytryptoline (pinoline) are the most active monoamine oxidase inhibitors (MAOIs) with IC50s of 0.5 μM and 1.5 μM respectively, using 5-hydroxytryptamine (serotonin) as substrate. Tryptolines are also potent reuptake inhibitors of serotonin and epinephrine, with a significantly greater selectivity for serotonin. Comparison of the inhibition kinetics of tetrahydro-β-carbolines for serotonin and epinephrine reuptake to that of the platelet aggregation response to these amines has shown that 5-hydroxymethtryptoline, methtryptoline, and tryptoline are poor inhibitors of reuptake. In all respects 5-hydroxytryptoline and 5-methoxytryptoline showed greater pharmacological activity than the tryptoline and methtryptoline. Although the in vivo formation of tryptolines has been a matter of controversy, they have profound pharmacological activity. See also
References
4 : Alkaloids|Beta-Carbolines|Tryptamines|Monoamine oxidase inhibitors |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。