- Structural studies
- References
- External links
| Name = tryptophanase
| EC_number = 4.1.99.1
| CAS_number = 9024-00-4
| IUBMB_EC_number = 4/1/99/1
| GO_code = 0009034
| image = 4w1y.jpg
| width = 270
| caption = Tryptophanase tetramer, E.Coli
}}
In enzymology, a tryptophanase ({{EC number|4.1.99.1}}) is an enzyme that catalyzes the chemical reaction
L-tryptophan + H2Oindole + pyruvate + NH3
Thus, the two substrates of this enzyme are L-tryptophan and H2O, whereas its 3 products are indole, pyruvate, and NH3.
This enzyme belongs to the family of lyases, specifically in the "catch-all" class of carbon-carbon lyases. The systematic name of this enzyme class is L-tryptophan indole-lyase (deaminating; pyruvate-forming). Other names in common use include L-tryptophanase, and L-tryptophan indole-lyase (deaminating). This enzyme participates in tryptophan metabolism and nitrogen metabolism. It has 2 cofactors: pyridoxal phosphate, and Potassium.
Structural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1AX4}}, {{PDB link|2C44}}, and {{PDB link|2OQX}}.
References
- {{cite journal | vauthors = BURNS RO, DEMOSS RD | date = 1962 | title = Properties of tryptophanase from Escherichia coli | journal = Biochim. Biophys. Acta | volume = 65 | pages = 233–44 | pmid = 14017164 | doi = 10.1016/0006-3002(62)91042-9 | issue = 2 }}
- {{cite journal | vauthors = Cowell JL, Maser K, DeMoss, RD | date = 1973 | title = Tryptophanase from Aeromonas liquifaciens. Purification, molecular weight and some chemical, catalytic and immunological properties | journal = Biochim. Biophys. Acta | volume = 315 | pages = 449–463 | doi=10.1016/0005-2744(73)90276-3}}
- {{cite journal | vauthors = NEWTON WA, MORINO Y, SNELL EE | date = 1965 | title = PROPERTIES OF CRYSTALLINE TRYPTOPHANASE | journal = J. Biol. Chem. | volume = 240 | pages = 1211–8 | pmid = 14284727 }}
External links
- {{Commonscatinline}}
- Philip Courtenay (disambiguation)
- Philip Courtenay I
- Philip Cox & Partners
- Philip Cranmer
- Philip Cresey Jr.
- Philip Crosbie Morrison
- Philip Crosland
- Philip C. Sorensen
- Philip C. Stead
- Philip Cummings
- Philip Cummins
- Philip Currie (disambiguation)
- Philip Curtiss
- Philip Cushion
- Philip C. Wolf
- Philip Dadd
- Philip Dakin Wagoner
- Philip Dalbiac
- Philip Dalidakis
- Philip Daniel Bolden
- Philip Davey
- Philip Davey (disambiguation)
- Philip David Kaltenbacher
- Philip David Morehead
- Philip David Warren