“Tryptophan—tRNA ligase”的意思、由来-开放百科全书

词条

Tryptophan—tRNA ligase

释义

Structural studies
References

{{enzyme
| Name = tryptophan-tRNA ligase
| EC_number = 6.1.1.2
| CAS_number = 9023-44-3
| IUBMB_EC_number = 6/1/1/2
| GO_code = 0004830
| image =
| width =
| caption =
}}

In enzymology, a tryptophan-tRNA ligase ({{EC number|6.1.1.2}}) is an enzyme that catalyzes the chemical reaction

ATP + L-tryptophan + tRNATrp AMP + diphosphate + L-tryptophyl-tRNATrp

The 3 substrates of this enzyme are ATP, L-tryptophan, and tRNA(Trp), whereas its 3 products are AMP, diphosphate, and L-tryptophyl-tRNATrp.

This enzyme belongs to the family of ligases, to be specific those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-tryptophan:tRNATrp ligase (AMP-forming). Other names in common use include tryptophanyl-tRNA synthetase, L-tryptophan-tRNATrp ligase (AMP-forming), tryptophanyl-transfer ribonucleate synthetase, tryptophanyl-transfer ribonucleic acid synthetase, tryptophanyl-transfer RNA synthetase, tryptophanyl ribonucleic synthetase, tryptophanyl-transfer ribonucleic synthetase, tryptophanyl-tRNA synthase, tryptophan translase, and TrpRS. This enzyme participates in tryptophan metabolism and aminoacyl-trna biosynthesis.

Structural studies

As of late 2007, 21 structures have been solved for this class of enzymes, with PDB accession codes {{PDB link|1D2R}}, {{PDB link|1I6K}}, {{PDB link|1I6L}}, {{PDB link|1I6M}}, {{PDB link|1M83}}, {{PDB link|1MAU}}, {{PDB link|1MAW}}, {{PDB link|1MB2}}, {{PDB link|1O5T}}, {{PDB link|1R6T}}, {{PDB link|1R6U}}, {{PDB link|1ULH}}, {{PDB link|1YIA}}, {{PDB link|1YID}}, {{PDB link|2A4M}}, {{PDB link|2AKE}}, {{PDB link|2AZX}}, {{PDB link|2DR2}}, {{PDB link|2G36}}, {{PDB link|2IP1}}, and {{PDB link|2OV4}}.

References

{{cite journal | vauthors = DAVIE EW, KONINGSBERGER VV, LIPMANN F | year = 1956 | title = The isolation of a tryptophan-activating enzyme from pancreas | journal = Arch. Biochem. Biophys. | volume = 65 | pages = 21–38 | pmid = 13373404 | doi = 10.1016/0003-9861(56)90173-4 | issue = 1 }}
{{cite journal | author = Preddie EC | year = 1969 | title = Tryptophanyl transfer ribonucleic acid synthetase from bovine pancreas. II. The chemically different subunits | journal = J. Biol. Chem. | volume = 244 | pages = 3958–68 | pmid = 5805407 | issue = 14 }}
{{cite journal | vauthors = Wong KK, Meister A, Moldave K | year = 1959 | title = Enzymic formation of ribonucleic acid-amino acid from synthetic aminoacyladenylate and ribonucleic acid | journal = Biochim. Biophys. Acta | volume = 36 | pages = 531–533 | doi = 10.1016/0006-3002(59)90196-9 | pmid=13845797}}

{{Ligases CO CS and CN}}{{Enzymes}}{{Portal bar|Molecular and Cellular Biology|border=no}}{{ligase-stub}}{{DEFAULTSORT:Tryptophan-tRNA ligase}}

2 : EC 6.1.1|Enzymes of known structure

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