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词条 Two-pore-domain potassium channel
释义

  1. See also

  2. References

  3. External links

{{distinguish|text=the small family of two-pore channels}}

The two-pore-domain potassium channel is a family of 15 members that form what is known as "leak channels" which possess Goldman-Hodgkin-Katz (open) rectification.[1] These channels are regulated by several mechanisms including signaling lipids, oxygen tension, pH, mechanical stretch, and G-proteins .{{citation needed|date=January 2013}} Their name is derived from the fact that the α subunits consist of four transmembrane segments, each containing two pore loops. As such, they structurally correspond to two inward-rectifier α subunits and thus form dimers in the membrane.

Below is a list of the 15 known two-pore-domain human potassium channels:[1]

Gene Channel[2] Family Aliases
KCNK1}} K2p1.1 TWIK[3][4] TWIK-1
KCNK2}} K2p2.1 TREK[3][4] TREK-1
KCNK3}} K2p3.1 TASK[3][4] TASK-1
KCNK4}} K2p4.1 TREK[3][4] TRAAK[5]
KCNK5}} K2p5.1 TASK[3][4] TASK-2[6]
KCNK6}} K2p6.1 TWIK[3][4] TWIK-2
KCNK7}} K2p7.1 TWIK[3][4]
KCNK9}} K2p9.1 TASK[3][4] TASK-3
KCNK10}} K2p10.1 TREK[3][4] TREK-2
KCNK12}} K2p12.1 THIK THIK-2
KCNK13}} K2p13.1 THIK THIK-1
KCNK15}} K2p15.1 TASK[3][4] TASK-5
KCNK16}} K2p16.1 TALK[3][4] TALK-1
KCNK17}} K2p17.1 TALK[3][4] TALK-2, TASK-4
KCNK18}} K2p18.1 TRIK, TRESK[3][4][7][8]

See also

  • Ion channel
  • Potassium channel

References

1. ^1 {{cite journal | vauthors = Goldstein SA, Bayliss DA, Kim D, Lesage F, Plant LD, Rajan S | title = International Union of Pharmacology. LV. Nomenclature and molecular relationships of two-P potassium channels | journal = Pharmacological Reviews | volume = 57 | issue = 4 | pages = 527–40 | date = Dec 2005 | pmid = 16382106 | doi = 10.1124/pr.57.4.12 }}
2. ^{{cite journal | vauthors = Gutman GA, Chandy KG, Adelman JP, Aiyar J, Bayliss DA, Clapham DE, Covarriubias M, Desir GV, Furuichi K, Ganetzky B, Garcia ML, Grissmer S, Jan LY, Karschin A, Kim D, Kuperschmidt S, Kurachi Y, Lazdunski M, Lesage F, Lester HA, McKinnon D, Nichols CG, O'Kelly I, Robbins J, Robertson GA, Rudy B, Sanguinetti M, Seino S, Stuehmer W, Tamkun MM, Vandenberg CA, Wei A, Wulff H, Wymore RS | display-authors = 6 | title = International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels | journal = Pharmacological Reviews | volume = 55 | issue = 4 | pages = 583–6 | date = Dec 2003 | pmid = 14657415 | doi = 10.1124/pr.55.4.9 }}
3. ^1 2 3 4 5 6 7 8 9 10 11 12 {{cite journal | vauthors = Enyedi P, Czirják G | title = Molecular background of leak K+ currents: two-pore domain potassium channels | journal = Physiological Reviews | volume = 90 | issue = 2 | pages = 559–605 | date = Apr 2010 | pmid = 20393194 | doi = 10.1152/physrev.00029.2009 }}
4. ^1 2 3 4 5 6 7 8 9 10 11 12 {{cite journal | vauthors = Lotshaw DP | title = Biophysical, pharmacological, and functional characteristics of cloned and native mammalian two-pore domain K+ channels | journal = Cell Biochemistry and Biophysics | volume = 47 | issue = 2 | pages = 209–56 | year = 2007 | pmid = 17652773 | doi = 10.1007/s12013-007-0007-8 }}
5. ^{{cite journal | vauthors = Fink M, Lesage F, Duprat F, Heurteaux C, Reyes R, Fosset M, Lazdunski M | title = A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids | journal = The EMBO Journal | volume = 17 | issue = 12 | pages = 3297–308 | date = Jun 1998 | pmid = 9628867 | pmc = 1170668 | doi = 10.1093/emboj/17.12.3297 }}
6. ^{{cite journal | vauthors = Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N | title = Potassium leak channels and the KCNK family of two-P-domain subunits | journal = Nature Reviews. Neuroscience | volume = 2 | issue = 3 | pages = 175–84 | date = Mar 2001 | pmid = 11256078 | doi = 10.1038/35058574 }}
7. ^{{cite journal | vauthors = Sano Y, Inamura K, Miyake A, Mochizuki S, Kitada C, Yokoi H, Nozawa K, Okada H, Matsushime H, Furuichi K | title = A novel two-pore domain K+ channel, TRESK, is localized in the spinal cord | journal = The Journal of Biological Chemistry | volume = 278 | issue = 30 | pages = 27406–12 | date = Jul 2003 | pmid = 12754259 | doi = 10.1074/jbc.M206810200 }}
8. ^{{cite journal | vauthors = Czirják G, Tóth ZE, Enyedi P | title = The two-pore domain K+ channel, TRESK, is activated by the cytoplasmic calcium signal through calcineurin | journal = The Journal of Biological Chemistry | volume = 279 | issue = 18 | pages = 18550–8 | date = Apr 2004 | pmid = 14981085 | doi = 10.1074/jbc.M312229200 }}

External links

  • {{MeshName|Tandem+Pore+Domain+Potassium+Channel}}
  • {{cite web | url = http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=79 | title = Two-P Potassium Channels | accessdate = | authorlink = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | archiveurl = | archivedate = | quote = }}
{{Ion channels|g3}}{{protein-stub}}

1 : Ion channels
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