| 词条 | Type I cytokine receptor |
| 释义 |
| Symbol = TypeI_recpt_CBD | Name = Type I cytokine receptor, cytokine-binding domain | image = | width = | caption = | InterPro= IPR015321 | SMART= | PROSITE = | SCOP = 1n26 | TCDB = | OPM family= | OPM protein= | Pfam= PF09240 | Pfam_clan=CL0159 | Membranome superfamily= 2 }} Type I cytokine receptors are transmembrane receptors expressed on the surface of cells that recognize and respond to cytokines with four α-helical strands. These receptors are also known under the name hemopoietin receptors, and share a common amino acid motif (WSXWS) in the extracellular portion adjacent to the cell membrane. Members of the type I cytokine receptor family comprise different chains, some of which are involved in ligand/cytokine interaction and others that are involved in signal transduction. The common cytokine-binding domain is related to the Fibronectin type III domain. Signal transduction chainsThe signal transducing chains are often shared between different receptors within this receptor family.[1]
ExamplesType I cytokine receptors include interleukin receptors, colony stimulating factor receptors and other cytokine receptors Interleukin receptors{{Type 1 interleukin receptors}}Colony stimulating factor receptors
Hormone receptor/neuropeptide receptor
Other
References1. ^{{cite book |author1=Lichtman, Andrew H. |author2=Abbas, Abul K. | title = Cellular and molecular immunology | publisher = Saunders | location = Philadelphia | year = 2003 | edition = 5th | pages = | isbn = 0-7216-0008-5 | oclc = | doi = }} 2. ^{{cite journal |vauthors=He YW, Adkins B, Furse RK, Malek TR | title = Expression and function of the gamma c subunit of the IL-2, IL-4, and IL-7 receptors. Distinct interaction of gamma c in the IL-4 receptor | journal = J. Immunol. | volume = 154 | issue = 4 | pages = 1596–605 | year = 1995 | pmid = 7530740 | doi = | issn = | url = http://www.jimmunol.org/cgi/content/abstract/154/4/1596 }} 3. ^{{cite journal |vauthors=Asao H, Okuyama C, Kumaki S, Ishii N, Tsuchiya S, Foster K, Sugamura K | title = Cutting edge: the common γ-chain is an indispensable subunit of the IL21 receptor complex| journal = J. Immunol. | volume = 167 | issue = 1 | pages = 1–5 | year = 2001 | doi = | issn = | pmid = 11418623}} 4. ^{{cite journal |vauthors=Stomski FC, Woodcock JM, Zacharakis B, Bagley CJ, Sun Q, Lopez AF | title = Identification of a Cys motif in the common beta chain of the interleukin 3, granulocyte-macrophage colony-stimulating factor, and interleukin 5 receptors essential for disulfide-linked receptor heterodimerization and activation of all three receptors | journal = J. Biol. Chem. | volume = 273 | issue = 2 | pages = 1192–9 | year = 1998 | pmid = 9422786 | doi = 10.1074/jbc.273.2.1192 }} 5. ^{{cite journal|last1=Cirillo|first1=Donatella|last2=Rachiglio|first2=Anna Maria|last3=la Montagna|first3=Raffaele|last4=Giordano|first4=Antonio|last5=Normanno|first5=Nicola|title=Leptin signaling in breast cancer: An overview|journal=Journal of Cellular Biochemistry|date=1 November 2008|volume=105|issue=4|pages=956–964|doi=10.1002/jcb.21911}} External links
2 : Cytokine receptors|Type I cytokine receptors |
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