| 词条 | U12 minor spliceosomal RNA |
| 释义 |
| Name = U12 minor spliceosomal RNA | image = RF00007.jpg | width = | caption = Predicted secondary structure and sequence conservation of U12 | Symbol = U12 | AltSymbols = | Rfam = RF00007 | miRBase = | miRBase_family = | RNA_type = Gene; snRNA; splicing | Tax_domain = Eukaryota | GO = {{GO|0000371}} {{GO|0045131}} {{GO|0005693}} | SO = {{SO|0000399}} | CAS_number = | EntrezGene = | HGNCid = | OMIM = | PDB = | RefSeq = | Chromosome = | Arm = | Band = | LocusSupplementaryData = }} U12 minor spliceosomal RNA is formed from U12 small nuclear (snRNA), together with U4atac/U6atac, U5, and U11 snRNAs and associated proteins, forms a spliceosome that cleaves a divergent class of low-abundance pre-mRNA introns. Although the U12 sequence is very divergent from that of U2, the two are functionally analogous.[1] The predicted secondary structure of U12 RNA is published,[2] but the alternative single hairpin in the 3' end shown here seems to better match the alignment of divergent Drosophila melanogaster and Arabidopsis thaliana sequences.[3] The sequences U12 introns that are spliced out are collected in a biological database called the U12 intron database. References{{Reflist|2}} External links
3 : Small nuclear RNA|Spliceosome|RNA splicing |
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