| 词条 | U7 small nuclear RNA |
| 释义 |
| Name = U7 small nuclear RNA | image = RF00066.jpg | width = | caption = Predicted secondary structure and sequence conservation of U7 | Symbol = U7 | AltSymbols = | Rfam = RF00066 | miRBase = | miRBase_family = | RNA_type = Gene; snRNA | Tax_domain = Eukaryota | GO = | SO = {{SO|0000274}} | CAS_number = | EntrezGene = | HGNCid = | OMIM = | PDB = | RefSeq = | Chromosome = | Arm = | Band = | LocusSupplementaryData = }} The U7 small nuclear RNA (U7 snRNA) is an RNA molecule and a component of the small nuclear ribonucleoprotein complex (U7 snRNP). The U7 snRNA is required for histone pre-mRNA processing. The 5' end of the U7 snRNA binds the HDE (histone downstream element), a conserved purine-rich region, located 15 nucleotides downstream the histone mRNA cleavage site.[1][2] The binding of the HDE region by the U7 snRNA, through complementary base-pairing, is an important step for the future recruitment of cleavage factors during histone pre-mRNA processing.[3] See also
References1. ^{{cite journal |vauthors=Spycher C, Streit A, Stefanovic B, Albrecht D, Koning TH, Schümperli D |title=3' end processing of mouse histone pre-mRNA: evidence for additional base-pairing between U7 snRNA and pre-mRNA |journal=Nucleic Acids Res |volume=22 |pages=4023–4030 |year=1994 |pmid=7937126| doi = 10.1093/nar/22.20.4023 | issue = 20 | pmc = 331885}} 2. ^{{cite journal |vauthors=Mowry KL, Steitz JA |title=Identification of the human U7 snRNP as one of several factors involved in the 3' end maturation of histone premessenger RNA's |journal=Science |volume=238 |issue=4834 |pages=1682–1687 |year=1987 |pmid=2825355| doi = 10.1126/science.2825355}} 3. ^{{Cite journal|last=Marzluff|first=William F.|last2=Wagner|first2=Eric J.|last3=Duronio|first3=Robert J.|title=Metabolism and regulation of canonical histone mRNAs: life without a poly(A) tail|url=http://www.nature.com/doifinder/10.1038/nrg2438|journal=Nature Reviews Genetics|volume=9|issue=11|pages=843–854|doi=10.1038/nrg2438|pmc=2715827|pmid=18927579}} 4. ^{{cite journal |vauthors=Voigt T, Meyer K, Baum O, Schümperli D |title=Ultrastructural changes in diaphragm neuromuscular junctions in a severe mouse model for Spinal Muscular Atrophy and their prevention by bifunctional U7 snRNA correcting SMN2 splicing |journal=Neuromuscul Disord |volume=20 |issue=11 |pages=744–752 |year=2010 |pmid=20832308 |doi=10.1016/j.nmd.2010.06.010}} 5. ^{{cite journal |vauthors=Ruepp MD, Vivarelli S, Pillai RS, Kleinschmidt N, Azzouz TN, Barabino SM, Schümperli D |title=The 68 kDa subunit of mammalian cleavage factor I interacts with the U7 small nuclear ribonucleoprotein and participates in 3'-end processing of animal histone mRNAs |journal=Nucleic Acids Res |volume= 38|issue= 21|pages= 7637–7650|year=2010 |pmid=20634199 |pmc=2995043 |doi=10.1093/nar/gkq613}} 6. ^{{cite journal |author=Geib T, Hertel KJ |title=Restoration of full-length SMN promoted by adenoviral vectors expressing RNA antisense oligonucleotides embedded in U7 snRNAs |journal=PLoS ONE |volume=4 |issue=12 |pages=e8204 |year=2009 |pmid=19997596 |pmc=2781471 |doi=10.1371/journal.pone.0008204 |editor1-last=Valcarcel |editor1-first=Juan}} 7. ^{{cite journal |vauthors=Godfrey AC, White AE, Tatomer DC, Marzluff WF, Duronio RJ |title=The Drosophila U7 snRNP proteins Lsm10 and Lsm11 are required for histone pre-mRNA processing and play an essential role in development |journal=RNA |volume=15 |issue=9 |pages=1661–1672 |year=2009 |pmid=19620235 |pmc=2743060 |doi=10.1261/rna.1518009}} 8. ^{{cite journal |vauthors=Yang XC, Torres MP, Marzluff WF, Dominski Z |title=Three proteins of the U7-specific Sm ring function as the molecular ruler to determine the site of 3'-end processing in mammalian histone pre-mRNA |journal=Mol Cell Biol |volume=29 |issue=15 |pages=4045–4056 |year=2009 |pmid=19470752 |pmc=2715809 |doi=10.1128/MCB.00296-09}} 9. ^{{cite journal |vauthors=Goyenvalle A, Babbs A, van Ommen GJ, Garcia L, Davies KE |title=Enhanced exon-skipping induced by U7 snRNA carrying a splicing silencer sequence: Promising tool for DMD therapy |journal=Mol Ther |volume=17 |issue=7 |pages=1234–1240 |year=2009 |pmid=19455105 |pmc=2835201 |doi=10.1038/mt.2009.113}} 10. ^{{cite journal |vauthors=Meyer K, Marquis J, Trüb J, Nlend Nlend R, Verp S, Ruepp MD, Imboden H, Barde I, Trono D, Schümperli D |title=Rescue of a severe mouse model for spinal muscular atrophy by U7 snRNA-mediated splicing modulation |journal=Hum Mol Genet |volume=18 |issue=3 |pages=546–555 |year=2009 |pmid=19010792 |doi=10.1093/hmg/ddn382}} 11. ^{{cite journal |vauthors=Marquis J, Kämpfer SS, Angehrn L, Schümperli D |title=Doxycycline-controlled splicing modulation by regulated antisense U7 snRNA expression cassettes |journal=Gene Ther |volume=16 |issue=1 |pages=70–77 |year=2009 |pmid=18701908 |doi=10.1038/gt.2008.138}} 12. ^{{cite journal |vauthors=Marz M, Mosig A, Stadler BM, Stadler PF |title=U7 snRNAs: a computational survey |journal=Genomics Proteomics Bioinformatics |volume=5 |issue=3–4 |pages=187–195 |year=2007 |pmid=18267300 |doi=10.1016/S1672-0229(08)60006-6}} 13. ^{{cite journal |vauthors=Higuchi T, Anzai K, Kobayashi S |title=U7 snRNA acts as a transcriptional regulator interacting with an inverted CCAAT sequence-binding transcription factor NF-Y |journal=Biochim Biophys Acta |volume=1780 |issue=2 |pages=274–281 |year=2008 |pmid=18078822 |doi=10.1016/j.bbagen.2007.11.005}} 14. ^{{cite journal |vauthors=Friend K, Lovejoy AF, Steitz JA |title=U2 snRNP binds intronless histone pre-mRNAs to facilitate U7-snRNP-dependent 3' end formation |journal=Mol Cell |volume=28 |issue=2 |pages=240–252 |year=2007 |pmid=17964263 |pmc=2149891 |doi=10.1016/j.molcel.2007.09.026}} 15. ^{{cite journal |vauthors=Uchikawa H, Fujii K, Kohno Y, Katsumata N, Nagao K, Yamada M, Miyashita T |title=U7 snRNA-mediated correction of aberrant splicing caused by activation of cryptic splice sites |journal=J Hum Genet |volume=52 |issue=11 |pages=891–897 |year=2007 |pmid=17851636 |doi=10.1007/s10038-007-0192-8}} 16. ^{{cite journal |vauthors=Marquis J, Meyer K, Angehrn L, Kämpfer SS, Rothen-Rutishauser B, Schümperli D |title=Spinal muscular atrophy: SMN2 pre-mRNA splicing corrected by a U7 snRNA derivative carrying a splicing enhancer sequence |journal=Mol Ther |volume=15 |issue=8 |pages=1479–1486 |year=2007 |pmid=17505471 |doi=10.1038/sj.mt.6300200}} 17. ^{{cite journal |vauthors=Asparuhova MB, Marti G, Liu S, Serhan F, Trono D, Schümperli D |title=Inhibition of HIV-1 multiplication by a modified U7 snRNA inducing Tat and Rev exon skipping |journal=J Gene Med |volume=9 |issue=5 |pages=323–334 |year=2007 |pmid=17474072 |doi=10.1002/jgm.1027}} 18. ^{{cite journal |author=Scheuerbrandt G |title=Exon skipping with U7 gene transfer |journal=Acta Myol |volume=25 |issue=1 |pages=40–2 |year=2006 |pmid=17039980}} 19. ^{{cite journal |vauthors=Jaeger S, Martin F, Rudinger-Thirion J, Giegé R, Eriani G |title=Binding of human SLBP on the 3'-UTR of histone precursor H4-12 mRNA induces structural rearrangements that enable U7 snRNA anchoring |journal=Nucleic Acids Res |volume=34 |issue=17 |pages=4987–4995 |year=2006 |pmid=16982637 |pmc=1635294 |doi=10.1093/nar/gkl666}} 20. ^{{cite journal |vauthors=Wagner EJ, Marzluff WF |title=ZFP100, a component of the active U7 snRNP limiting for histone pre-mRNA processing, is required for entry into S phase |journal=Mol Cell Biol |volume=26 |issue=17 |pages=6702–6712 |year=2006 |pmid=16914750 |pmc=1592837 |doi=10.1128/MCB.00391-06}} 21. ^{{cite journal |vauthors=Kolev NG, Steitz JA |title=In vivo assembly of functional U7 snRNP requires RNA backbone flexibility within the Sm-binding site |journal=Nat Struct Mol Biol |volume=13 |issue=4 |pages=347–353 |year=2006 |pmid=16547514 |doi=10.1038/nsmb1075}} 22. ^{{cite journal |vauthors=Godfrey AC, Kupsco JM, Burch BD, Zimmerman RM, Dominski Z, Marzluff WF, Duronio RJ |title=U7 snRNA mutations in Drosophila block histone pre-mRNA processing and disrupt oogenesis |journal=RNA |volume=12 |issue=3 |pages=396–409 |year=2006 |pmid=16495235 |pmc=1383579 |doi=10.1261/rna.2270406}} 23. ^{{cite journal |vauthors=Madocsai C, Lim SR, Geib T, Lam BJ, Hertel KJ |title=Correction of SMN2 Pre-mRNA splicing by antisense U7 small nuclear RNAs |journal=Mol Ther |volume=12 |issue=6 |pages=1013–1022 |year=2005 |pmid=16226920 |doi=10.1016/j.ymthe.2005.08.022}} 24. ^{{cite journal |vauthors=Azzouz TN, Pillai RS, Däpp C, Chari A, Meister G, Kambach C, Fischer U, Schümperli D |title=Toward an assembly line for U7 snRNPs: interactions of U7-specific Lsm proteins with PRMT5 and SMN complexes |journal=J Biol Chem |volume=280 |issue=41 |pages=34435–34440 |year=2005 |pmid=16087681 |doi=10.1074/jbc.M505077200}} 25. ^{{cite journal |vauthors=Azzouz TN, Gruber A, Schümperli D |title=U7 snRNP-specific Lsm11 protein: dual binding contacts with the 100 kDa zinc finger processing factor (ZFP100) and a ZFP100-independent function in histone RNA 3' end processing |journal=Nucleic Acids Res |volume=33 |issue=7 |pages=2106–2117 |year=2005 |pmid=15824063 |pmc=1075925 |doi=10.1093/nar/gki516}} 26. ^{{cite journal |vauthors=Goyenvalle A, Vulin A, Fougerousse F, Leturcq F, Kaplan JC, Garcia L, Danos O |title=Rescue of dystrophic muscle through U7 snRNA-mediated exon skipping |journal=Science |volume=306 |issue=5702 |pages=1796–1799 |year=2004 |pmid=15528407 |doi=10.1126/science.1104297}} 27. ^{{cite journal |vauthors=Schümperli D, Pillai RS |title=The special Sm core structure of the U7 snRNP: far-reaching significance of a small nuclear ribonucleoprotein |journal=Cell Mol Life Sci |volume=61 |issue=19–20 |pages=2560–2570 |year=2004 |pmid=15526162 |doi=10.1007/s00018-004-4190-0}} 28. ^{{cite journal |vauthors=Liu S, Asparuhova M, Brondani V, Ziekau I, Klimkait T, Schümperli D |title=Inhibition of HIV-1 multiplication by antisense U7 snRNAs and siRNAs targeting cyclophilin A |journal=Nucleic Acids Res |volume=32 |issue=12 |pages=3752–3759 |year=2004 |pmid=15254276 |pmc=484190 |doi=10.1093/nar/gkh715}} 29. ^{{cite journal |doi=10.1261/rna.5143303 |vauthors=Azzouz TN, Schumperli D |title=Evolutionary conservation of the U7 small nuclear ribonucleoprotein in Drosophila melanogaster |journal=RNA |volume=9 |issue=12 |pages=1532–1541 |year=2003 |pmid=14624008 |pmc=1370506}} 30. ^{{cite journal |vauthors=Pillai RS, Grimmler M, Meister G, Will CL, Lührmann R, Fischer U, Schümperli D |title=Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing |journal=Genes Dev |volume=17 |issue=18 |pages=2321–2333 |year=2003 |pmid=12975319 |pmc=196468 |doi=10.1101/gad.274403}} 31. ^{{cite journal |vauthors=Dominski Z, Yang XC, Purdy M, Marzluff WF |title=Cloning and characterization of the Drosophila U7 small nuclear RNA |journal=Proc Natl Acad Sci U S A |volume=100 |issue=16 |pages=9422–9427 |year=2003 |pmid=12872004 |pmc=170934 |doi=10.1073/pnas.1533509100}} 32. ^{{cite journal |doi=10.1007/s000180300047 |vauthors=Brun C, Suter D, Pauli C, Dunant P, Lochmüller H, Burgunder JM, Schümperli D, Weis J |title=U7 snRNAs induce correction of mutated dystrophin pre-mRNA by exon skipping |journal=Cell Mol Life Sci |volume=60 |issue=3 |pages=557–566 |year=2003 |pmid=12737315}} 33. ^{{cite journal |vauthors=Dominski Z, Erkmann JA, Yang X, Sànchez R, Marzluff WF |title=A novel zinc finger protein is associated with U7 snRNP and interacts with the stem-loop binding protein in the histone pre-mRNP to stimulate 3'-end processing |journal=Genes Dev |volume=16 |issue=1 |pages=58–71 |year=2002 |pmid=11782445 |pmc=155312 |doi=10.1101/gad.932302}} 34. ^{{cite journal |vauthors=Pillai RS, Will CL, Lührmann R, Schümperli D, Müller B |title=Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein |journal=EMBO J |volume=20 |issue=19 |pages=5470–5479 |year=2001 |pmid=11574479 |pmc=125645 |doi=10.1093/emboj/20.19.5470}} 35. ^{{cite journal |vauthors=Müller B, Link J, Smythe C |title=Assembly of U7 small nuclear ribonucleoprotein particle and histone RNA 3' processing in Xenopus egg extracts |journal=J Biol Chem |volume=275 |issue=32 |pages=24284–24293 |year=2000 |pmid=10827192 |doi=10.1074/jbc.M003253200}} 36. ^{{cite journal |doi=10.1007/s004120050385 |vauthors=Tuma RS, Roth MB |title=Induction of coiled body-like structures in Xenopus oocytes by U7 snRNA |journal=Chromosoma |volume=108 |issue=6 |pages=337–344 |year=1999 |pmid=10591993}} 37. ^{{cite journal |doi=10.1093/hmg/8.13.2415 |vauthors=Suter D, Tomasini R, Reber U, Gorman L, Kole R, Schümperli D |title=Double-target antisense U7 snRNAs promote efficient skipping of an aberrant exon in three human beta-thalassemic mutations |journal=Hum Mol Genet |volume=8 |issue=13 |pages=2415–2423 |year=1999 |pmid=10556289}} 38. ^{{cite journal |vauthors=Jacobs EY, Frey MR, Wu W, Ingledue TC, Gebuhr TC, Gao L, Marzluff WF, Matera AG |title=Coiled bodies preferentially associate with U4, U11, and U12 small nuclear RNA genes in interphase HeLa cells but not with U6 and U7 genes |journal=Mol Biol Cell |volume=10 |issue=5 |pages=1653–63 |year=1999 |pmid=10233169 |pmc=30488 |doi=10.1091/mbc.10.5.1653}} 39. ^{{cite journal |vauthors=Dominski Z, Zheng LX, Sanchez R, Marzluff WF |title=Stem-loop binding protein facilitates 3'-end formation by stabilizing U7 snRNP binding to histone pre-mRNA |journal=Mol Cell Biol |volume=19 |issue=5 |pages=3561–70 |year=1999 |pmid=10207079 |pmc=84148 |doi=10.1128/mcb.19.5.3561}} 40. ^{{cite journal |vauthors=Müller B, Schümperli D |title=The U7 snRNP and the hairpin binding protein: Key players in histone mRNA metabolism |journal=Semin Cell Dev Biol |volume=8 |issue=6 |pages=567–576 |year=1997 |pmid=9642171 |doi=10.1006/scdb.1997.0182}} 41. ^{{cite journal |doi=10.1073/pnas.95.9.4929 |vauthors=Gorman L, Suter D, Emerick V, Schümperli D, Kole R |title=Stable alteration of pre-mRNA splicing patterns by modified U7 small nuclear RNAs |journal=Proc Natl Acad Sci U S A |volume=95 |issue=9 |pages=4929–4934 |year=1998 |pmid=9560205 |pmc=20190}} 42. ^{{cite journal |doi=10.1073/pnas.93.25.14659 |vauthors=Scharl EC, Steitz JA |title=Length suppression in histone messenger RNA 3'-end maturation: processing defects of insertion mutant premessenger RNAs can be compensated by insertions into the U7 small nuclear RNA |journal=Proc Natl Acad Sci U S A |volume=93 |issue=25 |pages=14659–14664 |year=1996 |pmid=8962110 |pmc=26191}} 43. ^{{cite journal |vauthors=Wu CH, Murphy C, Gall JG |title=The Sm binding site targets U7 snRNA to coiled bodies (spheres) of amphibian oocytes |journal=RNA |volume=2 |issue=8 |pages=811–23 |year=1996 |pmid=8752090 |pmc=1369417}} 44. ^{{cite journal |vauthors=Turner PC, Whalen A, Schümperli D, Matera AG |title=The bona fide mouse U7 snRNA gene maps to a different chromosome than two U7 pseudogenes |journal=Genomics |volume=31 |issue=2 |pages=250–252 |year=1996 |pmid=8824812 |doi=10.1006/geno.1996.0042}} 45. ^{{cite journal |doi=10.1093/nar/23.16.3152 |vauthors=Stefanovic B, Wittop Koning TH, Schümperli D |title=A synthetic histone pre-mRNA-U7 small nuclear RNA chimera undergoing cis cleavage in the cytoplasm of Xenopus oocytes |journal=Nucleic Acids Res |volume=23 |issue=16 |pages=3152–3160 |year=1995 |pmid=7667091 |pmc=307172}} 46. ^{{cite journal |doi=10.1093/nar/23.16.3141 |vauthors=Stefanovic B, Hackl W, Lührmann R, Schümperli D |title=Assembly, nuclear import and function of U7 snRNPs studied by microinjection of synthetic U7 RNA into Xenopus oocytes |journal=Nucleic Acids Res |volume=23 |issue=16 |pages=3141–3151 |year=1995 |pmid=7667090 |pmc=307171}} 47. ^{{cite journal |doi=10.1073/pnas.92.13.5915 |vauthors=Frey MR, Matera AG |title=Coiled bodies contain U7 small nuclear RNA and associate with specific DNA sequences in interphase human cells |journal=Proc Natl Acad Sci U S A |volume=92 |issue=13 |pages=5915–5919 |year=1995 |pmid=7597053 |pmc=41612}} 48. ^{{cite journal |vauthors=Scharl EC, Steitz JA |title=The site of 3' end formation of histone messenger RNA is a fixed distance from the downstream element recognized by the U7 snRNP |journal=EMBO J |volume=13 |issue=10 |pages=2432–40 |year=1994 |pmid=8194533 |pmc=395109}} 49. ^{{cite journal |doi=10.1016/0020-711X(94)90156-2 |vauthors=Pironcheva G, Russev G |title=Isolation and purification of U7 snRNP particles |journal=Int J Biochem |volume=26 |issue=2 |pages=269–272 |year=1994 |pmid=8174762}} 50. ^{{cite journal |vauthors=Pironcheva G, Russev G |title=Isolation and purification of U7 and snRNP particles |journal=Microbios |volume=79 |issue=321 |pages=223–9 |year=1994 |pmid=7837994}} 51. ^{{cite journal |vauthors=Bond U, Yario TA |title=The steady state levels and structure of the U7 snRNP are constant during the human cell cycle: lack of cell cycle regulation of histone mRNA 3' end formation |journal=Cell Mol Biol Res |volume=40 |issue=1 |pages=27–34 |year=1994 |pmid=7804324}} 52. ^{{cite journal |vauthors=Pironcheva G, Russev G |title=Characterization of the protein moiety of U7 small nuclear RNP particles |journal=Microbios |volume=77 |issue=310 |pages=41–6 |year=1994 |pmid=7512683}} 53. ^{{cite journal |doi=10.1073/pnas.90.13.6257 |vauthors=Wu CH, Gall JG |title=U7 small nuclear RNA in C snurposomes of the Xenopus germinal vesicle |journal=Proc Natl Acad Sci U S A |volume=90 |issue=13 |pages=6257–6259 |year=1993 |pmid=8327506 |pmc=46907}} 54. ^{{cite journal |vauthors=Grimm C, Stefanovic B, Schümperli D |title=The low abundance of U7 snRNA is partly determined by its Sm binding site |journal=EMBO J |volume=12 |issue=3 |pages=1229–38 |year=1993 |pmid=8458335 |pmc=413326}} 55. ^{{cite journal |doi=10.1016/0378-1119(92)90104-W |vauthors=Watkins NJ, Phillips SC, Turner PC |title=The Xenopus U7 snRNA-encoding gene has an unusually compact structure |journal=Gene |volume=120 |issue=2 |pages=271–276 |year=1992 |pmid=1398140}} 56. ^{{cite journal |vauthors=Watkins NJ, Phillips SC, Turner PC |title=The U7 small nuclear RNA genes of Xenopus borealis |journal=Biochem Soc Trans |volume=20 |issue=3 |pages=301S |year=1992 |pmid=1426580 |doi=10.1042/bst020301s }} 57. ^{{cite journal |doi=10.1016/0378-1119(92)90514-P |vauthors=Phillips SC, Turner PC |title=A transcriptional analysis of the gene encoding mouse U7 small nuclear RNA |journal=Gene |volume=116 |issue=2 |pages=181–186 |year=1992 |pmid=1634116}} 58. ^{{cite journal |vauthors=Phillips SC, Birnstiel ML |title=Analysis of a gene cluster coding for the Xenopus laevis U7 snRNA |journal=Biochim Biophys Acta |volume=1131 |issue=1 |pages=95–8 |year=1992 |pmid=1374647 |doi=10.1016/0167-4781(92)90104-8}} 59. ^{{cite journal |vauthors=Kirby BJ, Turner PC |title=Primer extension analysis of mouse U7 small nuclear RNA gene expression |journal=Biochem Soc Trans |volume=20 |issue=1 |pages=45S |year=1992 |pmid=1633969 |doi=10.1042/bst020045s }} 60. ^{{cite journal |vauthors=Melin L, Soldati D, Mital R, Streit A, Schümperli D |title=Biochemical demonstration of complex formation of histone pre-mRNA with U7 small nuclear ribonucleoprotein and hairpin binding factors |journal=EMBO J |volume=11 |issue=2 |pages=691–7 |year=1992 |pmid=1531633 |pmc=556501}} 61. ^{{cite journal |vauthors=Murray BA, Turner PC |title=Copy number of the U7 gene in some mammalian species |journal=Biochem Soc Trans |volume=20 |issue=1 |pages=28S |year=1992 |pmid=1386043|doi=10.1042/bst020028s}} 62. ^{{cite journal |doi=10.1073/pnas.88.21.9784 |vauthors=Smith HO, Tabiti K, Schaffner G, Soldati D, Albrecht U, Birnstiel ML |title=Two-step affinity purification of U7 small nuclear ribonucleoprotein particles using complementary biotinylated 2'-O-methyl oligoribonucleotides |journal=Proc Natl Acad Sci U S A |volume=88 |issue=21 |pages=9784–9788 |year=1991 |pmid=1835087 |pmc=52805}} 63. ^{{cite journal |doi=10.1101/gad.5.9.1709 |vauthors=Bond UM, Yario TA, Steitz JA |title=Multiple processing-defective mutations in a mammalian histone pre-mRNA are suppressed by compensatory changes in U7 RNA both in vivo and in vitro |journal=Genes Dev |volume=5 |issue=9 |pages=1709–1722 |year=1991 |pmid=1885007}} 64. ^{{cite journal |vauthors=Phillips SC, Turner PC |title=Deletions downstream of the 3' box of the mouse U7 small nuclear RNA gene dramatically affect transcription |journal=Biochem Soc Trans |volume=19 |issue=3 |pages=342S |year=1991 |pmid=1783173|doi=10.1042/bst019342s}} 65. ^{{cite journal |vauthors=Turner PC, Phillips SC |title=Unusual compartmentalisation of mouse U7 small nuclear transcripts in Xenopus oocytes |journal=Biochem Soc Trans |volume=19 |issue=3 |pages=341S |year=1991 |pmid=1783172 |doi=10.1042/bst019341s }} 66. ^{{cite journal |vauthors=Phillips SC, Turner PC |title=The mouse U7 small nuclear RNA gene promoter functions efficiently in Xenopus oocytes |journal=Biochem Soc Trans |volume=19 |issue=3 |pages=339S |year=1991 |pmid=1783170 |doi=10.1042/bst019339s }} 67. ^{{cite journal |doi=10.1093/nar/19.10.2629 |vauthors=Cotten M, Oberhauser B, Brunar H, Holzner A, Issakides G, Noe CR, Schaffner G, Wagner E, Birnstiel ML |title=2'-O-methyl, 2'-O-ethyl oligoribonucleotides and phosphorothioate oligodeoxyribonucleotides as inhibitors of the in vitro U7 snRNP-dependent mRNA processing event |journal=Nucleic Acids Res |volume=19 |issue=10 |pages=2629–2635 |year=1991 |pmid=1710340 |pmc=328180}} 68. ^{{cite journal |doi=10.1093/nar/19.6.1344 |vauthors=Phillips SC, Turner PC |title=Nucleotide sequence of the mouse U7 snRNA gene |journal=Nucleic Acids Res |volume=19 |issue=6 |pages=1344–1344 |year=1991 |pmid=2030952 |pmc=333869}} 69. ^{{cite journal |vauthors=Gruber A, Soldati D, Burri M, Schümperli D |title=Isolation of an active gene and of two pseudogenes for mouse U7 small nuclear RNA |journal=Biochim Biophys Acta |volume=1088 |issue=1 |pages=151–4 |year=1991 |pmid=1989694 |doi=10.1016/0167-4781(91)90167-K}} 70. ^{{cite journal |doi=10.1016/0020-711X(91)90144-C |vauthors=Pironcheva G, Russev G |title=U7 snRNP particles bind H4 pre-mRNA in vitro |journal=Int J Biochem |volume=23 |issue=10 |pages=1049–1052 |year=1991 |pmid=1838527}} 71. ^{{cite journal |vauthors=Phillips SC, Turner PC |title=Sequence and expression of a mouse U7 snRNA type II pseudogene |journal=DNA Seq |volume=1 |issue=6 |pages=401–4 |year=1991 |pmid=1768864 |doi=10.3109/10425179109020796}} 72. ^{{cite journal |doi=10.1016/0378-1119(90)90378-5 |vauthors=Soldati D, Schümperli D |title=Structures of four human pseudogenes for U7 small nuclear RNA |journal=Gene |volume=95 |issue=2 |pages=305–306 |year=1990 |pmid=2249787}} 73. ^{{cite journal |vauthors=Hoffmann I, Birnstiel ML |title=Cell cycle-dependent regulation of histone precursor mRNA processing by modulation of U7 snRNA accessibility |journal=Nature |volume=346 |issue=6285 |pages=665–668 |year=1990 |pmid=1696685 |doi=10.1038/346665a0}} 74. ^{{cite journal |doi=10.1007/BF00360475 |vauthors=Schümperli D, Albrecht U, Koning TW, Melin L, Soldati D, Stauber C, Lührmann R |title=Biochemical studies of U7 snRNPs and of histone RNA 3' processing |journal=Mol Biol Rep |volume=14 |issue=2–3 |pages=205–206 |year=1990 |pmid=2141911}} 75. ^{{cite journal |doi=10.1101/gad.3.12b.2172 |vauthors=Kirsh AL, Groudine M, Challoner PB |title=Polyadenylation and U7 snRNP-mediated cleavage: alternative modes of RNA 3' processing in two avian histone H1 genes |journal=Genes Dev |volume=3 |issue=12B |pages=2172–2179 |year=1989 |pmid=2576416}} 76. ^{{cite journal |vauthors=Cotten M, Schaffner G, Birnstiel ML |title=Ribozyme, antisense RNA, and antisense DNA inhibition of U7 small nuclear ribonucleoprotein-mediated histone pre-mRNA processing in vitro |journal=Mol Cell Biol |volume=9 |issue=10 |pages=4479–87 |year=1989 |pmid=2479828 |pmc=362532}} 77. ^{{cite journal |doi=10.1073/pnas.86.12.4345 |vauthors=Vasserot AP, Schaufele FJ, Birnstiel ML |title=Conserved terminal hairpin sequences of histone mRNA precursors are not involved in duplex formation with the U7 RNA but act as a target site for a distinct processing factor |journal=Proc Natl Acad Sci U S A |volume=86 |issue=12 |pages=4345–4349 |year=1989 |pmid=2734288 |pmc=287265}} 78. ^{{cite journal |vauthors=Southgate C, Busslinger M |title=In vivo and in vitro expression of U7 snRNA genes: cis- and trans-acting elements required for RNA polymerase II-directed transcription |journal=EMBO J |volume=8 |issue=2 |pages=539–49 |year=1989 |pmid=2721491 |pmc=400839}} 79. ^{{cite journal |vauthors=Soldati D, Schümperli D |title=Structural and functional characterization of mouse U7 small nuclear RNA active in 3' processing of histone pre-mRNA |journal=Mol Cell Biol |volume=8 |issue=4 |pages=1518–24 |year=1988 |pmid=3380087 |pmc=363311}} 80. ^{{cite journal |vauthors=Cotten M, Gick O, Vasserot A, Schaffner G, Birnstiel ML |title=Specific contacts between mammalian U7 snRNA and histone precursor RNA are indispensable for the in vitro 3' RNA processing reaction |journal=EMBO J |volume=7 |issue=3 |pages=801–8 |year=1988 |pmid=3396543 |pmc=454395}} 81. ^{{cite journal |vauthors=Gilmartin GM, Schaufele F, Schaffner G, Birnstiel ML |title=Functional analysis of the sea urchin U7 small nuclear RNA |journal=Mol Cell Biol |volume=8 |issue=3 |pages=1076–84 |year=1988 |pmid=2835659 |pmc=363250}} 82. ^{{cite journal |vauthors=Strub K, Birnstiel ML |title=Genetic complementation in the Xenopus oocyte: co-expression of sea urchin histone and U7 RNAs restores 3' processing of H3 pre-mRNA in the oocyte |journal=EMBO J |volume=5 |issue=7 |pages=1675–82 |year=1986 |pmid=2943587 |pmc=1166994}} 83. ^{{cite journal |doi=10.1073/pnas.83.10.3243 |vauthors=De Lorenzi M, Rohrer U, Birnstiel ML |title=Analysis of a sea urchin gene cluster coding for the small nuclear U7 RNA, a rare RNA species implicated in the 3' editing of histone precursor mRNAs |journal=Proc Natl Acad Sci U S A |volume=83 |issue=10 |pages=3243–3247 |year=1986 |pmid=3458178 |pmc=323489}} 84. ^{{cite journal |vauthors=Strub K, Galli G, Busslinger M, Birnstiel ML |title=The cDNA sequences of the sea urchin U7 small nuclear RNA suggest specific contacts between histone mRNA precursor and U7 RNA during RNA processing |journal=EMBO J |volume=3 |issue=12 |pages=2801–7 |year=1984 |pmid=6084590 |pmc=557769}} Further readingExternal links
3 : RNA splicing|Small nuclear RNA|Spliceosome |
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