“UDP-N-acetylglucosamine 6-dehydrogenase”的意思、由来-开放百科全书

词条

UDP-N-acetylglucosamine 6-dehydrogenase

释义

References

{{enzyme
| Name = UDP-N-acetylglucosamine 6-dehydrogenase
| EC_number = 1.1.1.136
| CAS_number = 9054-83-5
| IUBMB_EC_number = 1/1/1/136
| GO_code = 0047004
| image =
| width =
| caption =
}}

In enzymology, an UDP-N-acetylglucosamine 6-dehydrogenase ({{EC number|1.1.1.136}}) is an enzyme that catalyzes the chemical reaction

UDP-N-acetyl-D-glucosamine + 2 NAD⁺ + H₂O UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate + 2 NADH + 2 H⁺

The 3 substrates of this enzyme are UDP-N-acetyl-D-glucosamine, NAD⁺, and H₂O, whereas its 3 products are UDP-N-acetyl-2-amino-2-deoxy-D-glucuronate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is UDP-N-acetyl-D-glucosamine:NAD⁺ 6-oxidoreductase. Other names in common use include uridine diphosphoacetylglucosamine dehydrogenase, UDP-acetylglucosamine dehydrogenase, UDP-2-acetamido-2-deoxy-D-glucose:NAD oxidoreductase, and UDP-GlcNAc dehydrogenase. This enzyme participates in aminosugars metabolism.

References

{{cite journal |vauthors=Fan DF, John CE, Zalitis J, Feingold DS | date = 1969 | title = UDPacetylglucosamine dehydrogenase from Achromobacter georgiopolitanum | journal = Arch. Biochem. Biophys. | volume = 135 | pages = 45–9 | pmid = 4312076 | doi = 10.1016/0003-9861(69)90514-1 | issue = 1 }}

3 : EC 1.1.1|NADH-dependent enzymes|Enzymes of unknown structure

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