| 词条 | Unoprostone |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 409092026 | IUPAC_name = (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-(3-oxodecyl) cyclopentyl]hept-5-enoic acid | image = Unoprostone.svg | tradename = Rescula | Drugs.com = {{drugs.com|CONS|unoprostone}} | pregnancy_AU = | pregnancy_US = C | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = Discontinued | legal_status = | routes_of_administration = Topical (eye drops) | bioavailability = | protein_bound = | metabolism = | elimination_half-life = 14 min | excretion = Renal | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 120373-36-6 | CAS_supplemental = {{CAS|120373-24-2}} (isopropyl ester) | ATC_prefix = S01 | ATC_suffix = EE02 | PubChem = 5311236 | DrugBank_Ref = {{drugbankcite|changed|drugbank}} | DrugBank = DB06826 | UNII_Ref = {{fdacite|changed|FDA}} | UNII = 6X4F561V3W | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D08661 | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 1201407 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 4470755 | C=22 | H=38 | O=5 | molecular_weight = 382.534 g/mol | smiles = O=C(O)CCC/C=C\\C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CCC(=O)CCCCCCC | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C22H38O5/c1-2-3-4-5-8-11-17(23)14-15-19-18(20(24)16-21(19)25)12-9-6-7-10-13-22(26)27/h6,9,18-21,24-25H,2-5,7-8,10-16H2,1H3,(H,26,27)/b9-6-/t18-,19-,20+,21-/m1/s1 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = TVHAZVBUYQMHBC-SNHXEXRGSA-N }}Unoprostone (INN) is a prostaglandin analogue. Its isopropyl ester, unoprostone isopropyl, was marketed under the trade name Rescula for the management of open-angle glaucoma and ocular hypertension, but is now discontinued in the US.[1] References1. ^{{drugs.com|CONS|unoprostone}} {{Antiglaucoma preparations and miotics}}{{Prostaglandins}}{{Prostanoidergics}}{{pharmacology-stub}} 1 : Prostaglandins |
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